Polymers, Volume 17, Issue 22
2025 November-2 - 124 articles
Cover Story: Colloidal stability and targeted delivery represent major challenges for mRNA therapeutics. Following intravenous administration, mRNA nanoparticles encounter protein adsorption and suffer from salt- and serum-induced aggregation. In this study, double-pH-responsive lipo-xenopeptides were combined with distinct PEGylated lipids to enhance colloidal stability and enable ligand-mediated targeted mRNA delivery. High transfection efficiency was maintained by pH-dependent PEG–lipid anchoring, which restored endosomal interaction. PEGylation additionally modulated the protein corona, thereby reducing protein adsorption. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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