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Biocompatible and Biodegradable Polymer Materials

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: 20 July 2025 | Viewed by 533

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Laboratorio de Ambiental, Facultad de Ingeniería Culiacán, Universidad Autónoma de Sinaloa, Ciudad Universitaria, Culiacán, Sinaloa P.O. Box: 80013, Mexico
Interests: synthesis and characterization of polymers; controlled drug delivery; polymeric carriers; water remediation; flocculants and adsorbents; chitosan; stimuli-responsive polymers
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Guest Editor
Laboratoire Chrono-Environnement, Université de Franche-Comté, 16 Route de Gray, 25000 Besançon, France
Interests: organic and macromolecular chemistry; environmental chemistry; water pollution; water purification technologies; wastewater engineering; adsorption processes; polysaccharides; cyclodextrins; chitosan; hemp; bioassays
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Guest Editor
Biopolymers Laboratory, CTAOA, Research Center for Food and Development, Hermosillo, Sonora, Mexico
Interests: polysaccharides; gels; rheology; biomaterials; controlled release; bioactive compounds
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Diverse polymer materials are intended to protect human health, preserve food products, and improve water treatment. In recent years, researchers have produced promising macromolecular structures that are more efficient, reaching controlled drug delivery while minimizing side effects in humans, maintaining the structural integrity of products, increasing the shelf life of food, and also removing a variety of contaminants in the water. Materials from modified natural polymers are preferred due to their biocompatibility, biodegradability, or eco-friendly nature. Additionally, "smart materials" are produced from sensitive polymers that respond to physical or chemical environmental changes. To date, different systems have been assessed for the delivery of active compounds (e.g., gels, micelles, liposomes, polyelectrolyte complexes, and emulsions), for preparing edible packaging (e.g., films and coatings), and to remove emerging contaminants from water (e.g., flocculants and adsorbents).  In this regard, developing innovative systems and performing more studies on host–guest interactions is essential.

This Special Issue aims to divulge advances in biocompatible and biodegradable polymers for medical applications, food packaging films/coatings, and eco-friendly flocculants and adsorbents of contaminants present in water. We welcome original papers and review articles addressing systems with outstanding properties for the abovementioned applications.

Dr. Lorenzo Antonio Picos Corrales
Dr. Grégorio Crini
Dr. Elizabeth Carvajal-Millán
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polysaccharides
  • chitosan
  • alginate
  • arabinogalactan
  • arabinoxylan
  • fucoidan
  • cyclodextrin polymers
  • stimuli-responsive polymers
  • pegylated drug delivery nanocarriers
  • encapsulation technologies
  • controlled drug delivery
  • nanomaterials for phototherapy
  • anticancer therapy
  • wound healing
  • nutraceutical formulations
  • cosmetotextiles
  • wound dressing
  • postharvest conservation
  • edible coatings
  • food packaging
  • bioassays
  • antioxidant capacity
  • biocompatibility
  • biodegradability
  • antimicrobial effect
  • water treatment
  • bioflocculation
  • adsorbents and biosorbents
  • emerging pollutants
  • organic pollutants
  • microplastics
  • host–guest interactions
  • mechanisms
  • colloidal systems

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Published Papers (2 papers)

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Research

25 pages, 5938 KiB  
Article
The Bactericide Effects of Chitosan When Used as an Indicator of Chlorine Demand
by Josefine Molina-Pinna and Félix R. Román-Velázquez
Polymers 2025, 17(9), 1226; https://doi.org/10.3390/polym17091226 (registering DOI) - 30 Apr 2025
Abstract
The Miradero Water Treatment Plant (MWTP) in Mayagüez, Puerto Rico, uses sodium hypochlorite (SH) as a disinfectant. However, SH reacts with humic substances present in surface water, forming disinfection by-products (DBPs) regulated by the U.S. EPA. This study evaluated whether chitosan, a biopolymer [...] Read more.
The Miradero Water Treatment Plant (MWTP) in Mayagüez, Puerto Rico, uses sodium hypochlorite (SH) as a disinfectant. However, SH reacts with humic substances present in surface water, forming disinfection by-products (DBPs) regulated by the U.S. EPA. This study evaluated whether chitosan, a biopolymer with known bactericidal properties, could reduce chlorine demand and improve disinfection. Chitosan, with a 75% degree of deacetylation and a molecular weight of 460 kDa, was solubilized in four acids (acetic, citric, hydrochloric, and L-ascorbic) and tested under two turbidity ranges (236.0 and 2556 NTU). Chlorine demand curves were generated, and coliform presence–absence (P–A) tests were performed to assess bactericidal effects. Results showed that chitosan-treated samples achieved disinfection at the breakpoint with lower SH doses. For water with a turbidity of 236.0 NTU, all chitosan-acid solutions reached the breakpoint at 3.60 mg/L of SH. At 2556 NTU, three solutions required 4.20 mg/L SH, while hydrochloric acid–chitosan required only 3.60 mg/L. All chitosan-treated samples tested negative for coliforms, while controls treated with SH alone tested positive. These findings demonstrate that chitosan enhances bacterial removal and reduces chlorine demand, potentially lowering DBP formation in water treatment. Full article
(This article belongs to the Special Issue Biocompatible and Biodegradable Polymer Materials)
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16 pages, 4953 KiB  
Article
Effect of Polydopamine-Coated Strontium-Doped Hydroxyapatite Nanowires on Bone Marrow Mesenchymal Stem Cells and Umbilical Vein Endothelial Cells
by Hanjing Li, Yucheng Liu, Longhai Peng, Chunyuan Du and Kui Zhou
Polymers 2025, 17(8), 1039; https://doi.org/10.3390/polym17081039 - 11 Apr 2025
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Abstract
Hydroxyapatite nanowires (HAW) can effectively improve the bone repair ability in bone engineered tissue. However, due to their single function, the application of HAWs in biological tissue engineering materials is limited. In this study, strontium-doped hydroxyapatite nanowires (SrHAW) were synthesized by a hydrothermal [...] Read more.
Hydroxyapatite nanowires (HAW) can effectively improve the bone repair ability in bone engineered tissue. However, due to their single function, the application of HAWs in biological tissue engineering materials is limited. In this study, strontium-doped hydroxyapatite nanowires (SrHAW) were synthesized by a hydrothermal method and coated with polydopamine (PDA) to improve the function of HAWs. The material structure, biocompatibility evaluation, and differentiation capability testing of PDA-coated strontium-doped hydroxyapatite (SrHAW@PDA) nanowires were conducted. Then, the nanowires were co-cultured with rat bone marrow mesenchymal stem cells (BMSCs) and rat umbilical vein endothelial cells (UVECs) to prepare cell spheroids. Compared with the undoped and uncoated HAW, the SrHAW@PDA nanowires enhanced the cell activity and their angiogenesis and osteogenesis abilities. In addition, their performance in the three-dimensional spheroid also played a positive role in the cells in the spheroid. Due to the presence of PDA, the adhesion between the cells in the three-dimensional spheroid and the nanowires were enhanced. In summary, these results show that SrHAW@PDA has the potential to be used as an alternative material to regulate cell biological activity in three-dimensional cell spheroids. Full article
(This article belongs to the Special Issue Biocompatible and Biodegradable Polymer Materials)
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