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Cancers, Volume 17, Issue 16

August-2 2025 - 121 articles

Cover Story: Ultrasound remains the main imaging modality for evaluating thyroid nodules. Several risk stratification systems using this method are available. However, the data analyzing these systems, or the evaluation of thyroid nodules in general, almost exclusively relies on static image captures. Using ultrasound video sequences, also known as cine-loops, is particularly beneficial for capturing an entire nodule within its surroundings. This approach provides more comprehensive data, has the potential to increase the diagnostic accuracy of risk stratification. Furthermore, cine-loops facilitate the contextualization of suspicious findings and enable reviewing of a whole organ, including all abnormalities. Data can be stored in PACS and reviewed at any time, which is particularly helpful for second readings, follow-ups, and educational purposes. View this paper
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Articles (121)

  • Review
  • Open Access
1,741 Views
24 Pages

Luminal and Basal Subtypes Across Carcinomas: Molecular Programs Beyond Tissue of Origin

  • Celia Gaona-Romero,
  • María Emilia Domínguez-Recio,
  • Iñaki Comino-Méndez,
  • María Victoria Ortega-Jiménez,
  • Rocío Lavado-Valenzuela and
  • Emilio Alba

21 August 2025

Carcinomas originate from polarized epithelia, displaying luminal and basal orientations with distinct biological properties. Regardless of tissue of origin, many carcinomas show luminal or basal traits that are reflected in molecular profiles and ar...

  • Review
  • Open Access
2,080 Views
13 Pages

Complete Mesocolic Excision for Colon Cancer: Insight into Potential Mechanisms of Oncologic Benefit

  • Fotios Seretis,
  • Antonia Panagaki,
  • Charalambos Seretis,
  • Maria Sotiropoulou,
  • Michail Psarologos,
  • Nikolaos Mamakos,
  • Konstantinos Polyzois,
  • Vasileios Drakopoulos and
  • Stylianos Kapiris

21 August 2025

Background/Objectives: Complete mesocolic excision (CME) has recently been proposed as a radical operation for the treatment of colon cancer. Increasing evidence suggests a survival benefit from this operation, although the exact reasons for this rem...

  • Systematic Review
  • Open Access
2,664 Views
44 Pages

Postoperative Pain Following Gynecology Oncological Surgery: A Systematic Review by Tumor Site

  • Selina Chiu,
  • Helen Staley,
  • Xiaoxi Zhang,
  • Anita Mitra,
  • Flavia Sorbi,
  • James Richard Smith,
  • Joseph Yazbek,
  • Sadaf Ghaem-Maghami,
  • Sanooj Soni and
  • Christina Fotopoulou
  • + 1 author

21 August 2025

Introduction: Postoperative pain management is complex and crucial in major gynecology oncological surgery. Currently, there is no well-defined standardized approach, resulting in significant variability in practices worldwide. This systematic review...

  • Article
  • Open Access
2,777 Views
22 Pages

21 August 2025

Background/Objectives: Breast cancer is the most commonly diagnosed cancer worldwide, with high rates of distant metastasis. While circulating tumor cells (CTCs) are the disseminatory units of metastasis and are indicative of a poor prognosis, CTC he...

  • Article
  • Open Access
1,841 Views
13 Pages

Predictors of Successful Whole-Body Hyperthermia in Cancer Patients: Target Temperature Achievement and Safety Analysis

  • Anna Lena Hohneck,
  • Vivien Schmitz-Solheid,
  • Deniz Gencer,
  • Maik Schroeder,
  • Hartmut Riess,
  • Annette Gerhards,
  • Iris Burkholder,
  • Stefan Heckel-Reusser,
  • Julia Gottfried and
  • Ralf-Dieter Hofheinz

21 August 2025

Aim: This study aimed to investigate the effectiveness and safety of whole-body hyperthermia (WBH) in cancer patients, identifying predictive factors for successful treatment (reaching target temperature ≥ 38.5 °C) and assessing adverse effect...

  • Review
  • Open Access
2,223 Views
24 Pages

Amplification-Free Testing of microRNA Biomarkers in Cancer

  • Bahareh Soleimanpour,
  • Juan Jose Diaz Mochon and
  • Salvatore Pernagallo

21 August 2025

Background: Circulating miRNAs have been identified as potential biomarkers for the early diagnosis and monitoring of cancers. However, limitations of polymerase chain reaction (PCR)-based methods are currently delaying the transition of miRNA resear...

  • Article
  • Open Access
3 Citations
3,311 Views
23 Pages

Targeting NRF2 and FSP1 to Overcome Ferroptosis Resistance in TSC2-Deficient and Cancer Cells

  • Tasmia Tahsin,
  • Darius K. McPhail,
  • Jesse D. Champion,
  • Mohammad A. M. Alzahrani,
  • Madeleine L. Hilditch,
  • Alexandre Faris-Orr,
  • Brian L. Calver,
  • James G. Cronin,
  • Juan C. Mareque-Rivas and
  • Darren W. Sexton
  • + 4 authors

21 August 2025

Background/Objectives: Ferroptosis is an iron-dependent form of regulated cell death driven by lipid peroxidation and holds promise as a therapeutic strategy against cancers with elevated iron metabolism. However, many tumors evade ferroptosis throug...

  • Article
  • Open Access
939 Views
14 Pages

21 August 2025

Background: Inter-rater reliability is critical in oncology to ensure consistent and reliable measurements across raters and methods, such as when evaluating biomarker levels in different laboratories or comparing tumor size assessments by radiation...

  • Article
  • Open Access
1,091 Views
19 Pages

Baseline Hemostatic Biomarker Assessment Identifies Breast Cancer Patients at High Risk for Venous Thromboembolism During Chemotherapy

  • Marina Marchetti,
  • Patricia Gomez-Rosas,
  • Laura Russo,
  • Carmen Julia Tartari,
  • Silvia Bolognini,
  • Chiara Ticozzi,
  • Debora Romeo,
  • Francesca Schieppati,
  • Luca Barcella and
  • Roberta Sarmiento
  • + 10 authors

20 August 2025

(1) Background: The presence of metastatic disease significantly increases the risk of venous thromboembolism (VTE) in breast cancer, particularly during chemotherapy. Although not categorized as a highly thrombogenic malignancy, the elevated global...

  • Article
  • Open Access
2 Citations
1,155 Views
20 Pages

20 August 2025

Background/Objectives: Head and neck squamous cell carcinoma (HNSCC) diagnosis and treatment rely heavily on computed tomography (CT) imaging to evaluate tumor characteristics and lymph node (LN) involvement, crucial for staging, prognosis, and thera...

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Cancers - ISSN 2072-6694