Existing and Emerging Biomarkers for Immune Checkpoint Immunotherapy in Solid Tumors (2nd Edition)
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Immunology and Immunotherapy".
Deadline for manuscript submissions: 20 November 2025 | Viewed by 491
Special Issue Editor
Interests: clinical cancer research; biomarkers; genitourinary cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is the second edition of a previous Special Issue entitled “Existing and Emerging Biomarkers for Immune Checkpoint Immunotherapy in Solid Tumors” (https://www.mdpi.com/journal/cancers/special_issues/QWO8SW601P).
Immunotherapy has revolutionized the treatment of cancer in recent years. Specifically, immune checkpoint inhibitors targeted to PD-1 or its ligand PD-L1 have changed the evolution of aggressive solid tumors, such as advanced lung cancer or melanoma. However, despite promising results, current immunotherapy is not effective for all patients, and, therefore, there is an urgent need for biomarker selection. PD-L1 measured by immunohistochemistry has demonstrated a correlation between expression and survival in some clinical trials, but these results have not been validated for all types of tumors and may vary depending on the antibody used in the different studies. Other tissue biomarkers, such as tumor mutational burden (TMB) or DNA repair defects (DRDs), have been explored, yielding controversial results. Some studies have reported that these alterations may release a higher number of tumor neoantigens, thus leading to an increased activation of the immune system and a greater benefit in terms of immunotherapy response. Another type of approach is to identify patient-dependent predictors of immunotherapy efficacy, such as the development of immune-related side effects or the identification of changes in immune phenotype. It may be particularly interesting to detect biomarkers in real time at different points of disease evolution to examine the constant dynamic changes of the immune system. This Special Issue will highlight the current complex uses of biomarkers in clinical practice and identify new potential immune biomarkers in solid tumors.
Dr. Nuria Romero-Laorden
Guest Editor
Manuscript Submission Information
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Keywords
- immunotherapy
- checkpoint inhibitors
- biomarkers
- immune biomarkers
- PD-L1
- TMB
- solid tumors
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