Myeloma: Pathogenesis and Targeted Therapies
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 32
Special Issue Editors
Interests: multiple myeloma; bone marrow microenvironment; molecular pathogenesis; CAR-T cell therapy; personalized medicine; drug resistance; immunotherapy targets; biomarkers; genetic alterations
Interests: multiple myeloma; plasma cell disease; management of hematological malignancies
Special Issue Information
Dear Colleagues,
Multiple myeloma is driven by progressive genetic mutations and abnormal signaling pathways that support malignant plasma cell proliferation and survival. The bone marrow microenvironment plays a key role by providing survival signals and facilitating immune evasion through cytokines, growth factors, and cell–cell interactions. Understanding these mechanisms has led to targeted therapies that disrupt tumor-supportive pathways, enhance immune recognition, and overcome resistance. Combinatorial approaches have shown synergistic effects, marking a significant shift in treatment strategies. This Special Issue highlights recent advances in the pathogenesis and targeted treatment of multiple myeloma, aiming to showcase novel diagnostic tools, therapeutic strategies, and individualized treatment approaches in this evolving field.
We are pleased to invite you to contribute your latest research and insights on multiple myeloma, with a focus on disease pathogenesis and the evolving landscape of targeted therapies.
This Special Issue aims to provide a comprehensive overview of recent advances in understanding and treating this complex malignancy. We welcome original research articles and reviews covering a broad range of topics, including pathophysiology, bioinformatics techniques for targeted discovery, therapeutic strategies, and immunotherapeutic approaches. We invite you to be part of this collaborative effort.
Dr. Fenghuang (Frank) Zhan
Dr. Gang An
Dr. Cody Ashby
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- multiple myeloma
- drug resistance
- car-t cell therapy
- immunotherapy targets
- biomarkers
- genetic alterations
- molecular pathogenesis
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