Research on Fluorescence-Guided Surgery in Cancer Treatment

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 1695

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Guest Editor
Department of Neurosurgery, Paracelsus Medical University, Nuremberg, Germany
Interests: glioma; brain tumors; fluorescence-guided surgery; confocal endomicroscopy; cranioplasty; traumatic brain injury

Special Issue Information

Dear Colleagues,

Fluorescence-guided surgery (FGS) is a novel technique that uses fluorescent agents to enhance the visualization of tumor margins and residual tumor cells during surgery. FGS has been shown to improve the extent of resection and the accuracy of biopsy in various types of cancers, such as gliomas, metastases, lymphomas, meningiomas, and others. However, FGS also faces some challenges, such as the limited availability of approved fluorescent agents, the variability of tumor fluorescence, the interference of background fluorescence, and the need for specialized equipment and training. This Special Issue aims to provide an overview of the current state of the art and the future perspectives of FGS in cancer treatment. If you are a neurosurgeon, neurologist, or other healthcare professional with expertise in these areas and are interested in sharing your research and insights with our audience, we encourage you to consider submitting an article for this Special Issue. Our goal is to provide a forum for the exchange of ideas and knowledge and to promote the advancement of neurosurgery. We welcome original research articles and review articles that contribute to our understanding of these exciting developments. Please contact us for more information and to submit your article.

Dr. Julius Höhne
Guest Editor

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Keywords

  • fluorescence-guided surgery
  • fluorescent agents
  • tumor fluorescence
  • tumor margin detection
  • residual tumor assessment
  • glioma surgery
  • fluorescein sodium
  • 5-aminolevulinic acid
  • confocal endomicroscopy
  • Raman spectroscopy

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Published Papers (1 paper)

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15 pages, 1695 KiB  
Systematic Review
Utility and Safety of 5-ALA Guided Surgery in Pediatric Brain Tumors: A Systematic Review
by Cheng Wang, Ying Yu, Yafei Wang, Jiahua Yu and Chenran Zhang
Cancers 2024, 16(21), 3677; https://doi.org/10.3390/cancers16213677 - 30 Oct 2024
Cited by 1 | Viewed by 1254
Abstract
Background: 5-Aminolevulinic acid-guided surgery for adult gliomas has been approved by the European Medicines Agency and the US Food and Drug Administration, becoming a reliable tool for improving gross total resection rates and patient outcomes. This has led several medical centers to explore [...] Read more.
Background: 5-Aminolevulinic acid-guided surgery for adult gliomas has been approved by the European Medicines Agency and the US Food and Drug Administration, becoming a reliable tool for improving gross total resection rates and patient outcomes. This has led several medical centers to explore the off-label use of 5-ALA in the resection of pediatric brain tumors, assessing its efficacy and safety across various tumor types. However, given the differences between children and adults, the appropriateness of 5-ALA use in pediatric populations has not yet been fully established. Methods: We collected eligible publications from Embase, Scopus, PubMed, and Proquest, ultimately selecting 27 studies. Data extraction and retrospective analysis of 249 surgical cases were conducted to determine the current efficacy and safety of 5-ALA in pediatric brain tumors. The fluorescence rate and utility stratified by several clinical features, including WHO grade, tumor classification, and tumor location, were analyzed. Results: Most studies suggest that 5-ALA can enhance tumor identification in high-grade tumors, including glioblastomas and anaplastic astrocytomas. Changes in survival or recurrence rates associated with 5-ALA-guided resection have not been reported. None of the cases reported significant postoperative complications related to the use of 5-ALA. Conclusions: 5-ALA can aid in the resection of high-grade gliomas in pediatric patients. The efficacy of 5-ALA in low-grade gliomas and other tumors may require enhancement with additional tools or modified administration protocols. The safety of 5-ALA has reached a preliminary consensus, although further randomized controlled trials and data on survival and molecular characteristics are needed. Full article
(This article belongs to the Special Issue Research on Fluorescence-Guided Surgery in Cancer Treatment)
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