Mesothelioma—from Diagnosis to Treatment

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 2601

Special Issue Editor


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Guest Editor
Department of Medical Oncology, Okayama Rosai Hospital, Okayama, Japan
Interests: lung cancer; malignant mesothelioma; chemotherapy; immunotherapy; asbestos-related diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Malignant pleural mesothelioma (MPM) is an aggressive neoplasm that develops in the mesothelial cell layer of the pleura. Exposure to asbestos is a well-known cause of MPM. The global incidence of MPM has continuously risen along with the widespread industrial use of asbestos. Recent progress in basic research and clinical practice has demonstrated some crucial evidence relating to molecular pathogenesis and perspectives on potential therapeutic approaches leading to promising treatment. In particular, immunotherapy has opened a door to favorable treatment options for patients with advanced diseases.

This Special Issue is designed to provide a state-of-the-art overview of recent scientific research on mesothelioma, including the pathogenesis, diagnosis, and management of MPM.
This Special Issue will identify the unmet needs in the diagnosis and management of MPM based on a combination of original research and review papers.

Topics will include:
The pathogenesis of MPM;
The challenge in the diagnosis of MPM;
The role of surgery in the treatment of MPM;
Systemic therapy of MPM including immunotherapy and/or chemotherapy;
Supportive care in MPM.

Dr. Nobukazu Fujimoto
Guest Editor

Manuscript Submission Information

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Keywords

  • asbestos
  • BAP-1
  • CAR-T
  • CTLA-4
  • immunotherapy
  • mesothelioma
  • PD-1
  • PD-L1

Published Papers (2 papers)

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Review

14 pages, 267 KiB  
Review
The Role of Surgery in Pleural Mesothelioma
by Moshe Lapidot and Martin Sattler
Cancers 2024, 16(9), 1719; https://doi.org/10.3390/cancers16091719 - 28 Apr 2024
Viewed by 738
Abstract
Surgery plays a central role in the diagnosis, staging, and management of pleural mesothelioma. Achieving an accurate diagnosis through surgical intervention and identifying the specific histologic subtype is crucial for determining the appropriate course of treatment. The histologic subtype guides decisions regarding the [...] Read more.
Surgery plays a central role in the diagnosis, staging, and management of pleural mesothelioma. Achieving an accurate diagnosis through surgical intervention and identifying the specific histologic subtype is crucial for determining the appropriate course of treatment. The histologic subtype guides decisions regarding the use of chemotherapy, immunotherapy, or multimodality treatment. The goal of surgery as part of multimodality treatment is to accomplish macroscopic complete resection with the eradication of grossly visible and palpable disease. Over the past two decades, many medical centers worldwide have shifted from performing extra-pleural pneumonectomy (EPP) to pleurectomy decortication (PD). This transition is motivated by the lower rates of short-term mortality and morbidity associated with PD and similar or even better long-term survival outcomes, compared to EPP. This review aims to outline the role of surgery in diagnosing, staging, and treating patients with pleural mesothelioma. Full article
(This article belongs to the Special Issue Mesothelioma—from Diagnosis to Treatment)
24 pages, 1423 KiB  
Review
Pleural Mesothelioma: Treatable Traits of a Heterogeneous Disease
by Francesco Rocco Bertuccio, Francesco Agustoni, Giulia Galli, Chandra Bortolotto, Jessica Saddi, Guido Baietto, Nicola Baio, Simone Montini, Paola Putignano, Gioacchino D’Ambrosio, Angelo G. Corsico, Paolo Pedrazzoli and Giulia Maria Stella
Cancers 2023, 15(24), 5731; https://doi.org/10.3390/cancers15245731 - 6 Dec 2023
Viewed by 1379
Abstract
Pleural mesothelioma is an aggressive disease with diffuse nature, low median survival, and prolonged latency presenting difficulty in prognosis, diagnosis, and treatment. Here, we review all these aspects to underline the progress being made in its investigation and to emphasize how much work [...] Read more.
Pleural mesothelioma is an aggressive disease with diffuse nature, low median survival, and prolonged latency presenting difficulty in prognosis, diagnosis, and treatment. Here, we review all these aspects to underline the progress being made in its investigation and to emphasize how much work remains to be carried out to improve prognosis and treatment. Full article
(This article belongs to the Special Issue Mesothelioma—from Diagnosis to Treatment)
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