Table of Contents
Nutrients, Volume 11, Issue 2 (February 2019)
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Cover Story (view full-size image) Oral glucosamine sulfate (GS) and chondroitin sulfate (CS), while widely marketed as [...] Read more. Oral glucosamine sulfate (GS) and chondroitin sulfate (CS), while widely marketed as joint-protective supplements, have limited intestinal absorption and are predominantly utilized by gut microbiota. The effects of these supplements on the gut microbiome are of great interest, and may clarify their mode of action, or explain heterogeneity in therapeutic responses. We conducted a systematic review of animal and human studies reporting the effects of GS or CS on gut microbial composition. Included studies varied in design, supplementation protocols, and microbiome assessment methods, and described associations between CS supplementation and increased abundance of Bacteroides, Desulfovibrio piger, and Bacteroidales S24-7, as well as decreased abundance of Lactobacillus. We discuss the possible implications of these associations for the host. View this paper