Special Issue "Plant Food, Nutrition and Human Health"
A special issue of Nutrients (ISSN 2072-6643).
Deadline for manuscript submissions: 31 August 2019.
This Special Issue, “Plant Food, Nutrition and Human Health”, should shed light on how phytochemicals or plant bioactives are metabolized and turned into bioavailable molecules that are able to impact different biological processes related to human health. Among the different classes of plant bioactive compounds, phenolic compounds, glucosinolates and other sulfur compounds, carotenoids, alkaloids, and terpenes have shown promising health promotion features in epidemiological and human intervention studies dealing with the prevention of non-communicable diseases. Nevertheless, the elucidation of their metabolic fate and bioavailability is a tipping point to fully unravel the preventive effects of plant bioactives on cardiovascular diseases, metabolic syndrome, neurodegenerative disorders, and certain kinds of cancer. Other than correctly evaluating the bioaccessibility of the bioactive(s) from the plant matrix, there is a need of addressing how the colonic microbiota can impact on their chemical structure, as well as on the inter-individual differences in bioavailability and bioefficacy due to the diversity of microbiota composition. Moreover, future research should be focused on the understanding of dose/phytochemical intake–response relationship with pharmacokinetic studies, evaluating proper biomarkers of intake. The design of nutritionally matched control/test foodstuffs is also required to conduct well controlled intervention studies with both animals and human subjects. In vitro investigations using physiologically achievable concentrations of circulating metabolites with appropriate model test systems are also encouraged to give adequate mechanistic insights. On the other hand, foodomics technologies (metabolomics, nutrigenomics, and proteomics) should be used to assess the role of bioactive compounds from a comprehensive perspective. Finally, new communication channels and educational programs able to bring to the general public to the well-defined biological properties of plant-derived bioactive compounds should be implemented.
In conclusion, this Special Issue should review all aspects concerning the metabolism, bioavailability, and biological properties of plant bioactives and attempt to solve current critical gaps. Novel methodologies or out-of-the-box approaches could also complement current knowledge and assist in the study of plant bioactives.Dr. Pedro Mena
Dr. Donato Angelino
Manuscript Submission Information
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- Dietary plant bioactives
- Phenolic compounds
- Glucosinolates and sulfur compounds
- Colonic metabolism
- Phase II metabolites
- Gut microbiota
- Human intervention trials