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Open AccessArticle

Chemical Characterization and Antiplatelet Potential of Bioactive Extract from Tomato Pomace (Byproduct of Tomato Paste)

1
Thematic Task Force on Healthy Aging, CUECH Research Network, Universidad de Talca, Talca 3460000, Chile
2
Interdisciplinary Center on Aging, Thrombosis Research Center, Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Universidad de Talca, Talca 3460000, Chile
3
Centro de Estudios en Alimentos Procesados (CEAP), CONCIYT, Gore Maule, Talca 3460000, Chile
4
Faculty of Agricultural Sciences, Universidad de Talca, Talca 3460000, Chile
5
Interdisciplinary Center for Health Studies, CIESAL, Faculty of Medicine, Universidad de Valparaíso, Angamos 655, Reñaca, Viña del Mar 2650000, Chile
6
Faculty of Health Sciences, School of Nursing, Universidad de Talca, Talca 3460000, Chile
*
Authors to whom correspondence should be addressed.
Nutrients 2019, 11(2), 456; https://doi.org/10.3390/nu11020456
Received: 13 January 2019 / Revised: 8 February 2019 / Accepted: 15 February 2019 / Published: 22 February 2019
We examined the ability of tomato pomace extract (by-product) to affect platelet aggregation in healthy humans (clinical pilot study). In phase 1 the tolerance of participants (n = 15; 5 per dose level) ingesting tomato pomace extract across three dose levels (1, 2.5, and 10 g) was evaluated. Phase 2 was a single-blind, placebo-controlled, parallel design human (male, n = 99; 33 per group) pilot intervention trial investigating the acute and repeated dose effects (5 days) of different doses of tomato pomace extract (1 g, 2.5 g or placebo) on platelet aggregation ex vivo. Various flavonoids (coumaric acid, floridzin, floretin, procyanidin B2, luteolin-7-O-glucoside, kaempferol, and quercitin) and nucleosides (adenosine, inosine, and guanosine) were identified in the tomato pomace extract. The clinical study showed that the daily consumption of 1 g of aqueous extract of tomato pomace for 5 days exerted an inhibitory activity on platelet aggregation. View Full-Text
Keywords: tomato pomace; extract; platelet; tolerance; clinical pilot study tomato pomace; extract; platelet; tolerance; clinical pilot study
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MDPI and ACS Style

Palomo, I.; Concha-Meyer, A.; Lutz, M.; Said, M.; Sáez, B.; Vásquez, A.; Fuentes, E. Chemical Characterization and Antiplatelet Potential of Bioactive Extract from Tomato Pomace (Byproduct of Tomato Paste). Nutrients 2019, 11, 456. https://doi.org/10.3390/nu11020456

AMA Style

Palomo I, Concha-Meyer A, Lutz M, Said M, Sáez B, Vásquez A, Fuentes E. Chemical Characterization and Antiplatelet Potential of Bioactive Extract from Tomato Pomace (Byproduct of Tomato Paste). Nutrients. 2019; 11(2):456. https://doi.org/10.3390/nu11020456

Chicago/Turabian Style

Palomo, Ivan; Concha-Meyer, Anibal; Lutz, Mariane; Said, Macarena; Sáez, Bárbara; Vásquez, Adriana; Fuentes, Eduardo. 2019. "Chemical Characterization and Antiplatelet Potential of Bioactive Extract from Tomato Pomace (Byproduct of Tomato Paste)" Nutrients 11, no. 2: 456. https://doi.org/10.3390/nu11020456

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