Leptin

Dear Colleagues,

From an historical point of view there little doubt that the main scienfic development in the field of obesity was the identification of leptin 25 years ago by J. Friedmann. Among many other things, this discovery allowed : a) the recognition of adipose tissue as the secretory organ, with leptin as one of the main adipokines; b) the understanding of the mechanisms governing the energy balance, with particular emphasis in the actions it exerts at the CNS; c) Newer effects exerted at the central level, including metabolic homeostasis, temperature or reward-related mechanisms; d) understanding the adaptations undertaken by many different endocrine systems (thyroid, gonadal, adrenal) in relation to the energy balance; e) the uncovering of some unexpected roles in the regulation of immune function and inflammatory processes; f) the definition of the diagnosis and genetic basis of some subtypes of human obesity (mutations in the leptin and the leptin receptor gene); and g) the treatment of patients with leptin deficiency, including patients with lipodystrophy.

In this Special Issue we welcome contributions related to any aspect of leptin, from mechanistic issues related to the leptin system, to its biological effects. We aim to provide readers with a clear view of the physiological relevance, the role of leptin in disease states including preclinical models, its diagnostic potential, and the therapeutic implications of the leptin system.

Prof. Carlos Diéguez González
Guest Editor

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