Table of Contents
Nutrients, Volume 11, Issue 3 (March 2019)
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Cover Story (view full-size image) Autism spectrum disorder (ASD) comprise a complex group of developmental disabilities characterized [...] Read more. Autism spectrum disorder (ASD) comprise a complex group of developmental disabilities characterized by impaired social interaction and communication together with repetitive and restrictive behaviors. In a relevant number of individuals with ASD, significant gastrointestinal dysfunctions accompany neurological alterations. Recent studies have suggested that altered composition of gut microbiota (i.e., dysbiosis) could be a potential cause of the gastrointestinal and central nervous system (CNS) symptoms. This might lead to malfunction of the gut-brain axis, the physiological bidirectional network that regulate CNS development and gut activity (Figure). The evidence that ASD can be associated with significant dysbiosis has led to the supposition that gut microbiota manipulation might be a rational therapeutic approach to these neurologic clinical problems. View this paper