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Nutrients, Volume 11, Issue 3

March 2019 - 224 articles

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Cover Story: Autism spectrum disorder (ASD) comprise a complex group of developmental disabilities characterized by impaired social interaction and communication together with repetitive and restrictive behaviors. In a relevant number of individuals with ASD, significant gastrointestinal dysfunctions accompany neurological alterations. Recent studies have suggested that altered composition of gut microbiota (i.e., dysbiosis) could be a potential cause of the gastrointestinal and central nervous system (CNS) symptoms. This might lead to malfunction of the gut-brain axis, the physiological bidirectional network that regulate CNS development and gut activity (Figure). The evidence that ASD can be associated with significant dysbiosis has led to the supposition that gut microbiota manipulation might be a rational therapeutic approach to these neurologic clinical problems. View this paper

Articles (224)

  • Article
  • Open Access
18 Citations
7,605 Views
11 Pages

Biological Response to Meal Ingestion: Gender Differences

  • Hugo Monrroy,
  • Giulio Borghi,
  • Teodora Pribic,
  • Carmen Galan,
  • Adoracion Nieto,
  • Nuria Amigo,
  • Anna Accarino,
  • Xavier Correig and
  • Fernando Azpiroz

26 March 2019

In a previous study, we demonstrated that women enjoyed and tolerated lower meal loads than men. Hence, we hypothesized that with the same meal load, their postprandial response is more pronounced than in men. We performed a randomized parallel trial...

  • Article
  • Open Access
8 Citations
6,783 Views
9 Pages

Pharmacokinetics of a New Pharmaceutical Form of Vitamin D3 100,000 IU in Soft Capsule

  • Romuald Mentaverri,
  • Jean-Claude Souberbielle,
  • Gilles Brami,
  • Christelle Daniel and
  • Patrice Fardellone

26 March 2019

Vitamin D deficiency is frequent in the general population and both subjects and health professionals could benefit from a broader range of vitamin D3 formulations. We conducted a single-dose, open-label, parallel-group, randomized bioequivalence stu...

  • Article
  • Open Access
67 Citations
6,553 Views
19 Pages

Induction of the Epithelial-to-Mesenchymal Transition of Human Colorectal Cancer by Human TNF-β (Lymphotoxin) and its Reversal by Resveratrol

  • Constanze Buhrmann,
  • Mina Yazdi,
  • Bastian Popper,
  • Ajaikumar B. Kunnumakkara,
  • Bharat B. Aggarwal and
  • Mehdi Shakibaei

26 March 2019

Objective: Tumor necrosis factor-beta (TNF-β), as an inflammatory mediator that has been shown to promote tumorigenesis, induces NF-κB. Natural multi-targeted agent resveratrol in turn shows anti-inflammatory and anti-cancer properties. Ep...

  • Article
  • Open Access
74 Citations
8,078 Views
15 Pages

Non-Alcoholic Fatty Liver Disease and Risk of Incident Type 2 Diabetes: Role of Circulating Branched-Chain Amino Acids

  • Eline H. van den Berg,
  • Jose L. Flores-Guerrero,
  • Eke G. Gruppen,
  • Martin H. de Borst,
  • Justyna Wolak-Dinsmore,
  • Margery A. Connelly,
  • Stephan J. L. Bakker and
  • Robin P. F. Dullaart

26 March 2019

Non-alcoholic fatty liver disease (NAFLD) is likely to be associated with elevated plasma branched-chain amino acids (BCAAs) and may precede the development of type 2 diabetes (T2D). We hypothesized that BCAAs may be involved in the pathogenesis of T...

  • Article
  • Open Access
18 Citations
6,403 Views
17 Pages

Assessment of the Effectiveness of a Computerised Decision-Support Tool for Health Professionals for the Prevention and Treatment of Childhood Obesity. Results from a Randomised Controlled Trial

  • George Moschonis,
  • Maria Michalopoulou,
  • Konstantina Tsoutsoulopoulou,
  • Elpis Vlachopapadopoulou,
  • Stefanos Michalacos,
  • Evangelia Charmandari,
  • George P. Chrousos and
  • Yannis Manios

26 March 2019

We examined the effectiveness of a computerised decision-support tool (DST), designed for paediatric healthcare professionals, as a means to tackle childhood obesity. A randomised controlled trial was conducted with 65 families of 6–12-year old...

  • Article
  • Open Access
12 Citations
6,532 Views
21 Pages

26 March 2019

Total amino acid (AA) restriction promotes hyperphagia and energy expenditure. We determined whether (i) methionine restriction mimics the effects of total AA restriction, (ii) methionine supplementation attenuates these responses, and iii) sympathet...

  • Article
  • Open Access
107 Citations
14,135 Views
14 Pages

25 March 2019

Recent research points to the bidimensional nature of orthorexia, with one dimension related to interest in healthy eating (healthy orthorexia) and another dimension related to a pathological preoccupation with eating healthily (orthorexia nervosa)....

  • Article
  • Open Access
61 Citations
9,908 Views
12 Pages

Higher Adherence to the Mediterranean Diet is Related to More Subjective Happiness in Adolescents: The Role of Health-Related Quality of Life

  • Rosario Ferrer-Cascales,
  • Natalia Albaladejo-Blázquez,
  • Nicolás Ruiz-Robledillo,
  • Violeta Clement-Carbonell,
  • Miriam Sánchez-SanSegundo and
  • Ana Zaragoza-Martí

25 March 2019

Adherence to the Mediterranean diet (MD) has previously been related to better quality of life in the general population. Further, children and adolescents have obtained better health outcomes when they have shown high adherence to the MD in recent s...

  • Article
  • Open Access
34 Citations
5,328 Views
14 Pages

25 March 2019

Protocatechuic acid (PCA), a strong antioxidant, has been reported for its cardiovascular-protective effects. This study aimed to investigate the effects of PCA administration on vascular endothelial function, mediated by insulin and insulin-like gro...

  • Article
  • Open Access
32 Citations
5,726 Views
19 Pages

25 March 2019

Background: Inflammation and mitochondrial dysfunction have been linked to trauma, neurodegeneration, and aging. Impairment of CISD2 expression may trigger the aforementioned pathological conditions in neural cells. We previously reported that curcum...

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