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Open AccessReview

Vitamin B12 in Relation to Oxidative Stress: A Systematic Review

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Division of Human Nutrition and Health, Wageningen University and Research, P.O. Box 17, 6700 AA Wageningen, The Netherlands
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FrieslandCampina, Stationsplein 4, 3818 LE Amersfoort, The Netherlands
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Author to whom correspondence should be addressed.
Nutrients 2019, 11(2), 482; https://doi.org/10.3390/nu11020482
Received: 22 January 2019 / Revised: 19 February 2019 / Accepted: 20 February 2019 / Published: 25 February 2019
The triage theory posits that modest micronutrient deficiencies may induce reallocation of nutrients to processes necessary for immediate survival at the expense of long-term health. Neglected processes could in time contribute to the onset of age-related diseases, in which oxidative stress is believed to be a major factor. Vitamin B12 (B12) appears to possess antioxidant properties. This review aims to summarise the potential antioxidant mechanisms of B12 and investigate B12 status in relation to oxidative stress markers. A systematic query-based search of PubMed was performed to identify eligible publications. The potential antioxidant properties of B12 include: (1) direct scavenging of reactive oxygen species (ROS), particularly superoxide; (2) indirect stimulation of ROS scavenging by preservation of glutathione; (3) modulation of cytokine and growth factor production to offer protection from immune response-induced oxidative stress; (4) reduction of homocysteine-induced oxidative stress; and (5) reduction of oxidative stress caused by advanced glycation end products. Some evidence appears to suggest that lower B12 status is related to increased pro-oxidant and decreased antioxidant status, both overall and for subclinically deficient individuals compared to those with normal B12 status. However, there is a lack of randomised controlled trials and prospective studies focusing specifically on the relation between B12 and oxidative stress in humans, resulting in a low strength of evidence. Further work is warranted. View Full-Text
Keywords: B12; cobalamin; oxidative stress; subclinical deficiency; deficiency; triage theory; age-related diseases; micronutrients; ROS; antioxidant B12; cobalamin; oxidative stress; subclinical deficiency; deficiency; triage theory; age-related diseases; micronutrients; ROS; antioxidant
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MDPI and ACS Style

van de Lagemaat, E.E.; de Groot, L.C.; van den Heuvel, E.G. Vitamin B12 in Relation to Oxidative Stress: A Systematic Review. Nutrients 2019, 11, 482.

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