Special Issue "Liver, Oxidative Stress and Metabolic Syndromes"
A special issue of Nutrients (ISSN 2072-6643).
Deadline for manuscript submissions: closed (31 March 2019)
This Special Issue “Liver, Oxidative Stress and Metabolic Syndromes” should shed light on different physiological hepatic functions, its several pathologies, and the mechanisms involved in these disorders. Moreover, it is focused on several therapeutic treatments considering also the different approaches, such as antioxidant, probiotic, prebiotics or a combination of both (symbiotics) substances.
The liver is a vital organ with numerous metabolic functions, including metabolism of both host and foreign molecules, glucose homeostasis, protein synthesis and detoxification. This organ is constantly exposed to viruses, pathogens and toxins, including gut microbiota. Moreover, this organ is often subjected to the injury related to overnutrition, obesity and metabolic syndrome. Lipid accumulation in hepatocytes has become one of the most frequent causes of liver abnormalities in Western countries. This pathology can cause histological abnormalities ranging from simple steatosis up to a progressive and chronic inflammation and, eventually, cirrhosis and hepatocellular carcinoma. It is known that many of these disorders are associated with hepatic changes in the enzymatic and non-enzymatic oxidative capacities. Thus, the oxidative stress, due to an increased reactive oxygen species (ROS) production, is one of the most important etiology of different liver disorders.
In conclusion, this Special Issue should review all aspects concerning the biological and biochemical mechanisms of hepatic physiological and pathological metabolism in order to ameliorate the therapeutic approaches of different disorders.
I encourage you to submit your manuscripts that fit with the objectives and topics of this Special Issue.
Prof. Rezzani Rita
Manuscript Submission Information
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