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Pharmaceuticals, Volume 16, Issue 5

May 2023 - 142 articles

Cover Story: G-protein-coupled receptors (GPCRs) represent valid molecular targets for directing peptide radioligands to malignant lesions. Diagnosis (γ-emitters: SPECT, β+-emitters: PET) and therapy (α, β-, Auger e- emitters: PRRT) are combined in a new promising “radiotheranostics” approach. Radiolabeled somatostatin analogs are widely used in neuroendocrine tumor patients, whereas peptide radioligands targeting other GPCRs in different tumors include bombesin, gastrin and exendin analogs. A recent switch from internalizing GPCR agonists to antagonists led to better pharmacokinetics and higher biosafety. GPCR antagonists do not activate their target receptor and do not elicit acute adverse effects when injected into patients. We herein discuss the challenges and opportunities of modern peptide radiotheranostics, focusing on GPCR antagonists. View this paper
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Articles (142)

  • Review
  • Open Access
14 Citations
4,346 Views
27 Pages

Carboxymethylated Gums and Derivatization: Strategies and Significance in Drug Delivery and Tissue Engineering

  • Madhuri Baghel,
  • Kalyani Sakure,
  • Tapan Kumar Giri,
  • Sabyasachi Maiti,
  • Kartik T. Nakhate,
  • Shreesh Ojha,
  • Charu Sharma,
  • Yogeeta Agrawal,
  • Sameer Goyal and
  • Hemant Badwaik

Natural polysaccharides have been widely exploited in drug delivery and tissue engineering research. They exhibit excellent biocompatibility and fewer adverse effects; however, it is challenging to assess their bioactivities to that of manufactured s...

  • Review
  • Open Access
6 Citations
4,984 Views
20 Pages

The Genus Dacryodes Vahl.: Ethnobotany, Phytochemistry and Biological Activities

  • Leseho Swana,
  • Bienvenu Tsakem,
  • Jacqueline V. Tembu,
  • Rémy B. Teponno,
  • Joy T. Folahan,
  • Jarmo-Charles Kalinski,
  • Alexandros Polyzois,
  • Guy Kamatou,
  • Louis P. Sandjo and
  • Jean Christopher Chamcheu
  • + 1 author

Dacryodes Vahl. species, belonging to the Burseraceae family, are widely used in traditional medicine in tropical regions to treat a range of ailments including malaria, wounds, tonsillitis, and ringworms. This review discusses the distribution, ethn...

  • Article
  • Open Access
4 Citations
2,730 Views
13 Pages

Rutin Gel with Bone Graft Accelerates Bone Formation in a Rabbit Model by Inhibiting MMPs and Enhancing Collagen Activities

  • Fahad F. Albaqami,
  • Hassan N. Althurwi,
  • Khalid M. Alharthy,
  • Abubaker M. Hamad and
  • Fatin A. Awartani

Bone graft techniques are used to compensate for bone loss in areas with deficient regeneration. However, matrix metalloproteases (MMPs) can limit bone formation by degrading extracellular matrices, which are required for bone regrowth. Noteworthily,...

  • Article
  • Open Access
26 Citations
6,050 Views
45 Pages

Brown seaweed is rich in phenolic compounds and has established health benefits. However, the phenolics present in Australian beach-cast seaweed are still unclear. This study investigated the effect of ultrasonication and conventional methodologies u...

  • Article
  • Open Access
4 Citations
3,257 Views
14 Pages

Prescribed Drugs and Self-Directed Violence: A Descriptive Study in the Spanish Pharmacovigilance Database

  • Ana Avedillo-Salas,
  • Javier Pueyo-Val,
  • Ana Fanlo-Villacampa,
  • Cristina Navarro-Pemán,
  • Francisco Javier Lanuza-Giménez,
  • Ignatios Ioakeim-Skoufa and
  • Jorge Vicente-Romero

Self-inflicted violence is a major and growing public health problem and its prediction and prevention is challenging for healthcare systems worldwide. Our aim was to identify prescribed drugs associated with self-directed violent behaviors in Spain....

  • Article
  • Open Access
6 Citations
3,898 Views
18 Pages

A Three-Step Process to Isolate Large Quantities of Bioactive Sesquiterpene Lactones from Cichorium intybus L. Roots and Semisynthesis of Chicory STLs Standards

  • Francesca Ruggieri,
  • Philippe Hance,
  • Bruna Gioia,
  • Alexandre Biela,
  • Pascal Roussel,
  • Jean-Louis Hilbert and
  • Nicolas Willand

Sesquiterpene lactones (STLs) are a large group of terpenoids most commonly found in plants of the Asteraceae family, e.g., in chicory plants, displaying a wide range of interesting biological activities. However, further studies on the biological po...

  • Review
  • Open Access
11 Citations
8,428 Views
13 Pages

The use of high-efficacy disease-modifying therapies (DMTs) early in the course of multiple sclerosis (MS) has been shown to improve clinical outcomes and is becoming an increasingly popular treatment strategy. As a result, monoclonal antibodies, inc...

  • Article
  • Open Access
15 Citations
3,381 Views
18 Pages

Based on their proven anti-inflammatory and antioxidant effects, recent studies have examined the therapeutic potential of the sodium-glucose cotransporter 2 (SGLT2) inhibitors in neurodevelopmental disorders such as autism spectrum disorder (ASD). T...

  • Article
  • Open Access
1 Citations
2,512 Views
13 Pages

Effect of the Composition of Leuzea and Cranberry Meal Extracts on Metabolic Processes in Norm and Pathology

  • Daria Khalikova,
  • Sergey An’kov,
  • Nataliya Zhukova,
  • Tatyana Tolstikova,
  • Sergey Popov and
  • Anastasia Saiko

This study was conducted to evaluate the effects of long-term administration of a new herbal composition of leuzea and cranberry meal extracts at a dose of 70:500 mg/kg in healthy and pathological mice. After 4 weeks of daily composition administrati...

  • Article
  • Open Access
11 Citations
3,485 Views
19 Pages

Drugs that cure COVID-19 have been marketed; however, this disease continues to ravage the world without becoming extinct, and thus, drug discoveries are still relevant. Since Mpro has known advantages as a drug target, such as the conserved nature o...

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Pharmaceuticals - ISSN 1424-8247