Int. J. Mol. Sci., Volume 20, Issue 24 (December-2 2019) – 260 articles
Cover Story (view full-size image): The G protein-coupled receptors (GPCRs) are at the forefront of the drug discovery initiative. Both the orthosteric and allosteric binding sites in GPCRs can be targeted by pharmacological treatments. Ocular degenerative disorders are often associated with impaired binding of the native chromophore 11-cis-retinal to rod opsin, resulting in aberrative protein folding and trafficking. These defects can be mitigated by pharmacological modulation with retinoid and nonretinoid molecules. View this paper.
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