Molecular Research on Neurodegenerative Diseases 2.0

Dear Colleagues,

This Special Issue is a continuation of our previous Special Issue "Molecular Research on Neurodegenerative Diseases" (https://www.mdpi.com/journal/ijms/special_issues/neurodegenerative_dis).

Many neurological disorders have been characterized by neurodegenerative processes, with key molecular signaling pathways participating in the cascade of cell death events. Even brain diseases, traditionally considered as acute central nervous system injury, such as stroke and traumatic brain injury, have now been recognized as presenting with major pathological components, known as hallmarks of chronic neurodegeneration. Among the many molecular signatures of neurodegeneration, specific molecules associated with inflammation and mitochondrial dysfunction have been implicated as pivotal checkpoints in the propagation of cell death mechanisms, yet also indicated as equally involved as robust targets for anchoring cell survival therapeutics. This Special Issue is dedicated to the recent research progress in deciphering molecular pathways mediating cell death and cell survival in neurodegeneration and its treatment. The goal is to provide an in-depth understanding of the underlying central role of neurodegeneration in brain diseases, and to exploit such knowledge in the development of novel molecule-based therapies against neurodegenerative disorders.

Prof. Dr. Cesar Borlongan
Dr. Eleonora Napoli
Guest Editors

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