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Special Issue "Gangliosides: Modes of Action and Cell Fates"
Deadline for manuscript submissions: closed (31 October 2019).
Gangliosides, sialic acid-containing glycosphingolipids are ubiquitously expressed mainly on the cell membrane in vertebrates. The structure of carbohydrate moieties varies depending on the development and differentiation of tissues and cells. In particular, the polymorphic alteration of gangliosides along with the development and differentiation of nervous tissues has suggested their roles in the organogenesis of nervous systems. In turn, some gangliosides have been considered to be cancer-associated antigens, and have been used as tumor markers and targets for antibody therapy. Since cDNAs for ganglioside synthases were isolated, the genetic modification of ganglioside expression in cultured cells and experimental animals has enabled us to substantially elucidate the roles of gangliosides in cancers and nervous systems. The main findings can be summarized as: (i) Gangliosides play a pivotal role in the maintenance of the integrity of nervous systems, and also in repair of damaged nerve tissues; (ii) Gangliosides are important for the architecture and function of membrane microdomains such as lipid rafts; and (iii) Gangliosides regulate cell signals at lipid rafts based on the interaction with ganglioside-recognizing molecules, leading to the decision of cell fates. The molecular cluster formation around gangliosides is now attracting many researchers in this field. We would like to focus on the modes of action and resulting cell fates to further understand the implication of gangliosides in our bodies. This Special Issue calls for original research and reviews and perspectives that address the progress and current knowledge in the research on gangliosides, their modes of action and cell fates.
Prof. Dr. Koichi Furukawa
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- acidic glycosphingolipids
- microdomains and lipid rafts
- molecular complex formation
- regulation of signaling
- cell–cell interaction
- recognition and interaction with glycolipids
- proliferation and differentiation
- activation and inactivation