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Special Issue "Molecular and Cellular Basis of Thrombotic Diseases"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 December 2019).
Interests: platelets; P2 receptors; ITAM receptors; signal transduction; platelet-neutrophil interactions; bacterial infection; inflammation; inflammation-associated cancer; mouse models; intravital microscopy; vascular integrity; thrombosis; valvular heart disease; aortic stenosis; prosthetic heart valves; transcatheter aortic valve implantation
Interests: platelets; metabolism; AMPK signaling; thrombosis; myocardial infarction; ventricular remodeling; fibrosis; cardiac fibroblast biology; endothelial barrier; stent; mouse models; translational research
Circulating platelets and coagulation play a crucial role in hemostasis, acting to maintain the integrity of a closed circulatory system after blood vessel injury. Under physiological conditions, regulatory mechanisms restrain thrombus formation. When pathologic processes disturb these mechanisms, thrombosis can occur either in the arterial or in the venous circulation with tremendous impact on human health. Thrombosis is the cause of ischemic heart disease, ischemic stroke, and venous thromboembolism, which account for one in four deaths worldwide.
Current antithrombotic therapy includes antiplatelet and anticoagulant drugs, preventing clot from forming and growing. However, these drugs have adverse side effects, most notably the increased risk of bleeding, and there remains a considerable incidence of thrombosis in patients receiving currently available therapy. There is an unmet medical need for novel antithrombotic agents or strategies with a more favorable safety profile, and better efficacy in certain high-risk patients. It is likely that a broader, more personalized and improved implementation of preventive measures will reduce the disease burden.
The discovery of novel cellular and molecular targets is the matter of intense ongoing research. This Special Issue is dedicated to the description of pathological cellular and molecular mechanisms underlying hemostatic imbalance and thrombosis, the identification of fundamental basis of disease, and the development of molecular interventions to prevent or treat them towards a molecular medicine perspective.
Dr. Oury Cécile
Dr. Sandrine Horman
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- vascular integrity
- molecular pathology
- risk factors