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Special Issue "Regulation of Gene Expression During Embryonic Development"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 31 January 2020.

Special Issue Editors

Guest Editor
Dr. Adam Davis E-Mail
University of North Georgia, Gainesville, Oakwood, GA, USA
Interests: Developmental Biology
Guest Editor
Dr. Jo Qian E-Mail
University of North Georgia, Gainesville, Oakwood, GA, USA
Interests: Developmental Biology
Guest Editor
Dr. Ghulam Hasnain E-Mail
University of North Georgia, Gainesville, Oakwood, GA, USA
Interests: Gene Expression

Special Issue Information

Dear Colleagues,

This Special Issue of the International Journal of Molecular Science shall encompass topics regarding the evolution of regulation of gene expression during eukaryotic embryonic development. Topics may include but not be limited to the evolution of differential gene expression at the level of transcription, mRNA processing, translation, and/or subcellular localization of protein expression. Further, data on how mutations at the level of the DNA have led to divergent gene regulation mechanisms, genetic regulatory networks, and/or the development of variable morphological structures between evolutionarily divergent lineages are acceptable. Research manuscripts and comprehensive reviews adhering to the journal’s aims will be accepted.

Dr. Adam Davis
Dr. Jo Qian
Dr. Ghulam Hasnain
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Research

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Open AccessArticle
Spatiotemporal Expression of Anticoagulation Factor Antistasin in Freshwater Leeches
Int. J. Mol. Sci. 2019, 20(16), 3994; https://doi.org/10.3390/ijms20163994 - 16 Aug 2019
Abstract
Antistasin, which was originally discovered in the salivary glands of the Mexican leech Haementeria officinalis, was newly isolated from Helobdella austinensis. To confirm the temporal expression of antistasin during embryogenesis, we carried out semi-quantitative RT-PCR. Hau-antistasin1 was uniquely expressed at [...] Read more.
Antistasin, which was originally discovered in the salivary glands of the Mexican leech Haementeria officinalis, was newly isolated from Helobdella austinensis. To confirm the temporal expression of antistasin during embryogenesis, we carried out semi-quantitative RT-PCR. Hau-antistasin1 was uniquely expressed at stage 4 of the cleavage and was strongly expressed in the late stages of organogenesis, as were other antistasin members. In order to confirm the spatial expression of antistasin, we performed fluorescence in situ hybridization in the late stages of organogenesis. The expression of each antistasin in the proboscis showed a similar pattern and varied in expression in the body. In addition, the spatial expression of antistasin orthologs in different leeches showed the possibility of different function across leech species. Hau-antistasin1 was expressed in the same region as hedgehog, which is a known mediator of signal transduction pathway. Hau-antistasin1 is probably a downstream target of Hedgehog signaling, involved in segment polarity signal pathway. Full article
(This article belongs to the Special Issue Regulation of Gene Expression During Embryonic Development)
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Review

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Open AccessReview
More than just Stem Cells: Functional Roles of the Transcription Factor Sox2 in Differentiated Glia and Neurons
Int. J. Mol. Sci. 2019, 20(18), 4540; https://doi.org/10.3390/ijms20184540 - 13 Sep 2019
Abstract
The Sox2 transcription factor, encoded by a gene conserved in animal evolution, has become widely known because of its functional relevance for stem cells. In the developing nervous system, Sox2 is active in neural stem cells, and important for their self-renewal; differentiation to [...] Read more.
The Sox2 transcription factor, encoded by a gene conserved in animal evolution, has become widely known because of its functional relevance for stem cells. In the developing nervous system, Sox2 is active in neural stem cells, and important for their self-renewal; differentiation to neurons and glia normally involves Sox2 downregulation. Recent evidence, however, identified specific types of fully differentiated neurons and glia that retain high Sox2 expression, and critically require Sox2 function, as revealed by functional studies in mouse and in other animals. Sox2 was found to control fundamental aspects of the biology of these cells, such as the development of correct neuronal connectivity. Sox2 downstream target genes identified within these cell types provide molecular mechanisms for cell-type-specific Sox2 neuronal and glial functions. SOX2 mutations in humans lead to a spectrum of nervous system defects, involving vision, movement control, and cognition; the identification of neurons and glia requiring Sox2 function, and the investigation of Sox2 roles and molecular targets within them, represents a novel perspective for the understanding of the pathogenesis of these defects. Full article
(This article belongs to the Special Issue Regulation of Gene Expression During Embryonic Development)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

A review about the role of Sox genes during sexual determination and differentiation

Author: Dr. Francisco J. Barrionuevo Jiménez

A short communication/opinion on Regulation of Gene Expression During Embryonic
Development

Author: Dr. Maura Calvani

A review in gene expression during eukaryotic development

Author: Dr. Julio Amigo

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