Special Issue "Sphingolipids: Metabolic Functions and Disorders"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (27 September 2019).
Interests: sphingolipidomics; sphingosine 1-phosphate; S1P-receptors; insulin resistance; dendritic cells; epigenetics; nanotoxicology
Special Issues and Collections in MDPI journals
A strong case is emerging that bioactive sphingolipids, although only a minor constituent of the global lipid milieu in cells and tissues, play a central role in regulating metabolic functions. Specific bioactive sphingolipids have been identified as pathogenic mediators in metabolic disorders such as non-alcoholic fatty liver disease (NAFLD), diabetes, or cardiovascular dysfunction. Circulating mediators that are released from adipose tissue (e.g., adipokines, inflammatory cytokines) specifically modulate enzymes that are involved in sphingolipid synthesis and degradation. The accumulation of specific sphingolipid species in tissues such as the liver, muscle, heart, pancreas, and vasculature may contribute to the onset and development of metabolic diseases including insulin resistance, pancreatic β-cell failure, liver dysfunction, neuro-muscolar degeneration, cardiomyopathy, and vascular and microenviromental dysfunctions. Striking progress has been made in the last few years in elucidating the complex crosstalk between sphingolipids and the development of metabolic diseases, as scientists have figured out that pharmacological intervention or genetic ablation of enzymes controlling sphingolipid synthesis or degradation have beneficial effects in these disorders.
In the Special Issue, “Sphingolipids: Metabolic Functions and Disorders”, we welcome your contributions in the form of original research and review articles on all aspects of sphingolipids and their role in physiological and pathophysiological metabolic processes.
Prof. Dr. Burkhard Kleuser
Assoc. Prof. Elisabetta Meacci
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- sphingosine 1-phosphate
- ceramide 1-phosphate
- insulin resistance
- beta-cell failure
- cardiovascular disease
- metabolic dysfunction