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Special Issue "Sphingolipids: Metabolic Functions and Disorders"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 27 September 2019

Special Issue Editors

Guest Editor
Prof. Dr. Burkhard Kleuser

Department of Nutritional Toxicology, Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany
Website | E-Mail
Interests: sphingolipidomics; sphingosine 1-phosphate; S1P-receptors; insulin resistance; dendritic cells; epigenetics; nanotoxicology
Guest Editor
Assoc. Prof. Elisabetta Meacci

Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, Molecular and Applied Biology Research Unit, University of Florence, Florence, Italy
Website | E-Mail

Special Issue Information

Dear Colleagues,

A strong case is emerging that bioactive sphingolipids, although only a minor constituent of the global lipid milieu in cells and tissues, play a central role in regulating metabolic functions. Specific bioactive sphingolipids have been identified as pathogenic mediators in metabolic disorders such as non-alcoholic fatty liver disease (NAFLD), diabetes, or cardiovascular dysfunction. Circulating mediators that are released from adipose tissue (e.g., adipokines, inflammatory cytokines) specifically modulate enzymes that are involved in sphingolipid synthesis and degradation. The accumulation of specific sphingolipid species in tissues such as the liver, muscle, heart, pancreas, and vasculature may contribute to the onset and development of metabolic diseases including insulin resistance, pancreatic β-cell failure, liver dysfunction, neuro-muscolar degeneration, cardiomyopathy, and vascular and microenviromental dysfunctions. Striking progress has been made in the last few years in elucidating the complex crosstalk between sphingolipids and the development of metabolic diseases, as scientists have figured out that pharmacological intervention or genetic ablation of enzymes controlling sphingolipid synthesis or degradation have beneficial effects in these disorders.

In the Special Issue, “Sphingolipids: Metabolic Functions and Disorders”, we welcome your contributions in the form of original research and review articles on all aspects of sphingolipids and their role in physiological and pathophysiological metabolic processes.

Prof. Dr. Burkhard Kleuser
Assoc. Prof. Elisabetta Meacci
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • sphingolipids
  • ceramide
  • sphingosine
  • sphingosine 1-phosphate
  • ceramide 1-phosphate
  • glycosphingolipids
  • diabetes
  • insulin resistance
  • beta-cell failure
  • cardiovascular disease
  • metabolic dysfunction

Related Special Issue

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Light stress-induced increase of Sphingosine 1-Phosphate in photoreceptors and its relevance to retinal degeneration
Authors: Ryo Terao, Megumi Honjo, Takashi Ueta, Hideru Obinata, Takashi Izumi, Makoto Kurano, Yutaka Yatomi, Hideto Koso, Sumiko Watanabe, Makoto Aihara

Title: The link between Gaucher disease and Parkinson disease sheds light on old and novel disorders of sphingolipid metabolism
Authors: Rossella Indellicato and Marco Trinchera

Title: Synergism of two S1P1 receptor modulators in an experimental clinical setting: different pharmacokinetic properties as an opportunity to mitigate first-dose heart rate effects
Authors: Pierre-Eric Juif, Mike Ufer and Jasper Dingemanse
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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