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Special Issue "Advances in Nanostructured Materials between Pharmaceutics and Biomedicine"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: 31 July 2019

Special Issue Editors

Guest Editor
Prof. Stefano Giovagnoli

Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy
Website | E-Mail
Interests: controlled release; solid state properties; organic and inorganic nano- microparticles; inhaled dry powders; drug physical modification; cell microencapsulation and engineering
Co-Guest Editor
Dr. Alessandro Di Michele

Department of Physics and Geology, University of Perugia, Italy
Website | E-Mail
Interests: nanomaterials; sonochemistry; catalysis; electron microscopy imaging

Special Issue Information

Dear Colleagues,

Nanostructured materials are materials containing an internal or surface structure in the nanometer length scale on which their properties depend. Organic, inorganic, and hybrid nanostructures find broad application across several areas of pharmaceutics and biomedicine. In particular, medicinal chemistry, drug delivery, and tissue engineering have benefited from the progress in such technologies. Considerable advances have characterized the recent application of nanostructured materials in medicine, from diagnostic biosensors to scaffolds for tissue engineering, without forgetting the high relevance in catalysis and biocatalysis applied to biology and chemical synthesis.

This Special Issue aims at the most recent advances in nanostructured material across chemistry and biology, including manufacturing and potential toxicity issues. Particular importance will be given to applications in medicinal chemistry and flow chemistry, targeted and local drug nanocarriers, nanostructured matrices for controlled release, biosensors, and functional nanomaterials and their biological relevance.

Prof. Dr. Stefano Giovagnoli
Dr. Alessandro Di Michele
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Nanostructured materials in medicinal chemistry
  • Nanomaterials and flow chemistry
  • Biofunctional nanomaterials
  • Nanostructured materials for catalysis
  • Nanostructured scaffolds for tissue engineering
  • Nanomaterials for local and targeted drug delivery
  • Nanostructured biosensors and diagnostic tools
  • Nanostructured scaffolds for biocatalysis
  • Nanostructured matrices for drug delivery
  • Nanostructured materials manufacturing
  • Nanomaterial toxicity
  • Nanomaterial functionalization and characterization
  • Nanomaterial structural analysis
  • Nanoparticles
  • Functional nanomaterials
  • Heterogenous catalysis
  • Biocatalysis
  • Flow chemistry
  • Biosensors
  • Diagnostics
  • Local and targeted drug delivery
  • Nanotoxicity
  • Nanostructured scaffolds

Published Papers (1 paper)

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Open AccessArticle
Evaluation of the Biological Behavior of a Gold Nanocore-Encapsulated Human Serum Albumin Nanoparticle ([email protected]) in a CT-26 Tumor/Ascites Mouse Model after Intravenous/Intraperitoneal Administration
Int. J. Mol. Sci. 2019, 20(1), 217; https://doi.org/10.3390/ijms20010217
Received: 21 November 2018 / Revised: 24 December 2018 / Accepted: 28 December 2018 / Published: 8 January 2019
PDF Full-text (3031 KB) | HTML Full-text | XML Full-text
Colorectal cancer is one of the major causes of cancer-related death in Taiwan and worldwide. Patients with peritoneal metastasis from colorectal cancer have reduced overall survival and poor prognosis. Hybrid protein-inorganic nanoparticle systems have displayed multifunctional applications in solid cancer theranostics. In this [...] Read more.
Colorectal cancer is one of the major causes of cancer-related death in Taiwan and worldwide. Patients with peritoneal metastasis from colorectal cancer have reduced overall survival and poor prognosis. Hybrid protein-inorganic nanoparticle systems have displayed multifunctional applications in solid cancer theranostics. In this study, a gold nanocore-encapsulated human serum albumin nanoparticle ([email protected]), which is a hybrid protein-inorganic nanoparticle, and its radioactive surrogate 111In-labeled [email protected] (111[email protected]), were developed and their biological behaviors were investigated in a tumor/ascites mouse model. 111[email protected] was injected either intravenously (iv) or intraperitoneally (ip) in CT-26 tumor/ascites-bearing mice. After ip injection, a remarkable and sustained radioactivity retention in the abdomen was noticed, based on microSPECT images. After iv injection, however, most of the radioactivity was accumulated in the mononuclear phagocyte system. The results of biodistribution indicated that ip administration was significantly more effective in increasing intraperitoneal concentration and tumor accumulation than iv administration. The ratios of area under the curve (AUC) of the ascites and tumors in the ip-injected group to those in the iv-injected group was 93 and 20, respectively. This study demonstrated that the ip injection route would be a better approach than iv injections for applying gold-albumin nanoparticle in peritoneal metastasis treatment. Full article

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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Multi-walled Carbon Nanotube-Induced Gene Expression Markers for Medical and Occupational Surveillance
Authors: Nancy Guo, etc.
Abstract: There are currently no effective biomarkers for detecting lung fibrosis or predicting the risk of lung cancer resulting from multi-walled carbon nanotube (MWCNT) exposure. This study compared in vivo mRNA and miRNA expression lung tissue and blood of mice exposed to MWCNT with in vitro mRNA and miRNA expression from a coculture model of human lung and microvascular cells. Concordant mRNAs and miRNAs identified by this study could be used to drive future studies confirming specific human biomarkers of MWCNT exposure. These potential biomarkers could be used to assess overall worker health and predict the occurrence of MWCNT-induced disease.
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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