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Special Issue "Small Vessel Disease: A Whole Brain Disease"
Deadline for manuscript submissions: 30 April 2020.
Cerebral small vessel disease (SVD) is an umbrella term covering a variety of abnormalities related to small blood vessels in the brain. SVD results from damage to the small penetrating arteries and arterioles in the brain, and its prevalence increases exponentially with aging: From approximately 6% to 7% at age 60 to 28% at age 80.
SVD is a common cause of stroke, cognitive impairment, and gait disturbances, which slowly progress to vascular Parkinsonism and dementia, but can be differentiated from Alzheimer's disease considering neuroimaging findings (it is associated with more extensive white matter lesions, less severe hippocampal atrophy, and the absence of cerebral amyloid angiopathy). Substantial evidence shows that small vessel disease shares many risk factors and prognostic impacts in specific clinical settings. In fact, the presence of small vessel disease confers a risk of hemorrhagic transformation in brain ischemia in 10% of cases. SVD increases the morbidity, disability, and healthcare costs of the growing elderly population, decreasing their quality of life. Its prevention and treatment are critical research and clinical priorities. Our work purposes would be to view the small vessel disease as a whole-brain pathology, with possible new biological markers, hemodynamic complex alterations, and cholinergic dysfunction, pointing out the dynamic process that links small vessel disease to subcortical dementia.
Prof. Dr. Rita Moretti
Dr. Paola Caruso
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- small vessel disease
- biological markers
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Pericytes in Microvessels: from “Mural” Function to Brain and Retina Regeneration
Aurhors: Carmelina Daniela Anfuso1* and Gabriella Lupo1*