Int. J. Mol. Sci., Volume 21, Issue 1 (January-1 2020) – 370 articles
Cover Story (view full-size image): Due to their capacity to engage in highly specific interactions with target receptors, peptides are increasingly being recognized as drugs and drug leads. Structural flexibility and the extremely wide chemical space accessible to peptides through residue variation complicate attempts at rational design. The common approach to identification and optimization of peptide ligands is therefore to screen vast combinatorial libraries. Here, synthetic and biological peptide library platforms are reviewed along with screening and diversification strategies mimicking natural evolutionary principles. View this paper.
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