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Special Issue "Hematopoietic Serine Proteases: Important Players in Inflammation and Tissue Homeostasis"
Deadline for manuscript submissions: 30 June 2020.
Interests: mast cells; basophilic leukocytes, neutrophilic leukocytes; serine proteases; cleavage specificity; phage display; IgE; evolution; allergy; vaccines; Fc receptors; dermatitis; cytokines; immune regulation
Several of the hematopoietic cell lineages store massive amounts of serine proteases in cytoplasmic secretory granules. These proteases, which can account for up to 35% of the total cellular protein, are stored in an active form, ready for rapid release upon cell activation. In mammals, these proteases are expressed primarily by mast cells, neutrophils, cytotoxic T cells, and NK cells and they are encoded from four different chromosomal loci. Known functions involve activation of apoptosis in target cells, inducing cytokine production, regulating blood pressure, inactivating snake and scorpion toxins, regulating coagulation, regulating cytokine activity as well as participating in tissue homeostasis. Some of them are very active and have a relatively broad specificity and thereby many potential targets, whereas others are highly specific with only one or a few selected targets. Although much is known about these proteases, very much remains unknown. A few examples of important unsolved questions are: why do mast cells continuously produce such high amounts of these proteases; another is the major target for one of the recently identified highly specific neutrophil proteases (NSP4); and what is the prime function of the most highly conserved members of this subfamily of serine proteases (the granzymes A and K)? This Special Issue will try to address some of these important outstanding questions in the area of hematopoietic serine proteases.
Prof. Lars Hellman
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- serine protease
- cleavage specificity
- mast cell
- neutrophilic granulocyte
- cytotoxic T cell
- NK cell
- immune regulation
- tissue homeostasis