Table of Contents
Int. J. Mol. Sci., Volume 18, Issue 12 (December 2017) – 280 articles
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Cover Story (view full-size image) The unprecedented crystal structure of Mycobacterium tuberculosis O6-alkylguanine-DNA [...] Read more. The unprecedented crystal structure of Mycobacterium tuberculosis O6-alkylguanine-DNA alkyltransferase (OGT) in complex, with a modified double-stranded DNA (dsDNA) reveals molecular details of the cooperative DNA binding mechanism of this suicidal enzyme. A peculiar supramolecular assembly can be observed in the OGT–dsDNA crystal lattice in which three different protein units are oriented onto the same DNA molecule. In particular, one protein unit binds a modified guanine base, while both additional protein monomers flip out a deoxyadenosine residue. View this paper