International Journal of Molecular Sciences, Volume 27, Issue 5

Breast cancer remains a leading cause of mortality among women worldwide, presenting significant treatment challenges due to its aggressive nature and lack of targeted therapies. Traditional treatments, including surgery, radiation, and chemotherapy,...

Phantom limb pain (PLP) is a frequent and often persistent consequence of limb amputation, characterized by pain perceived in the absent limb. Despite decades of research, its biological basis remains incompletely understood, and available treatments...

Short bowel syndrome (SBS) develops when the remaining intestine is unable to sustain adequate nutrient and electrolyte absorption following extensive bowel resection. The condition is characterized by malabsorption and significant fluid losses which...

Malaria remains a major global health challenge, driven in part by widespread antimalarial drug resistance in Plasmodium parasites. Artemisinin-based combination therapies (ACTs) are currently the first-line treatment; however, resistance has also em...

Mussaenda pubescens Dryand. is a medicinal plant widely used in traditional medicine in Southeast Asia for the treatment of inflammation, skin-related disorders, and other health conditions. Despite its ethnopharmacological significance, scientific e...

Intercellular communication is mediated by extracellular vesicles (EVs), particles released by all cell types that transfer bioactive cargo (proteins, lipids, nucleic acids) to recipient cells, influencing their function. Furthermore, the human popul...

Estimating the post-mortem interval (PMI) using microRNAs (miRNAs) in vitreous humor (VH) is a promising technique in forensic pathology. However, the reliability of quantitative Real-Time PCR (qPCR) data in this matrix is currently constrained by a...

Hair aging, a complex physiological process involving progressive hair thinning and loss of luster, is primarily driven by functional decline of hair follicle components and sebaceous glands due to cumulative oxidative stress. This decline manifests...

LINC01270 is a long intergenic noncoding RNA implicated in the progression of various cancers. In our previous study, we demonstrated that LINC01270 plays a role in regulating the pro-inflammatory response in the THP-1 monocytic cell line, partly thr...

The G-protein-coupled receptor cannabinoid receptor 2 (CB₂R) initiates a key signaling pathway in mammalian physiology and pathophysiology. CB₂R signaling holds significant therapeutic potential in ameliorating many pathologies, particularly in infla...

This study aimed to systematically identify the active constituents of Kadsura coccinea (Lem.) A. C. Smith (KC) and elucidate their potential mechanisms in treating rheumatoid arthritis (RA) using an integrated analytical and computational approach....

Fluoroquinolone antibiotics are widely used in medicine and in veterinary medicine. Due to their stable chemical structure, their residues have been detected in the aquatic environment. Photocatalytic degradation is one of the promising methods for t...

Plants are frequently exposed to various abiotic stresses during their growth and development. S. portulacastrum possesses inherent tolerance to salinity and heavy metals, yet the underlying molecular mechanisms remain poorly understood. In this stud...

This review article provides a systematic analysis of synthesis methods, structural characteristics, and functional properties of spinel-structured ferrite nanoparticles (MFe₂O₄). The physicochemical principles, advantages, and limitations of various...

The aim of this study was to compare the responses of normal human gingival epithelial cells (HGEpiC) and oral squamous cell carcinoma cells (OECM-1) to apigenin, a natural flavonoid, focusing on redox balance, autophagy, and apoptosis. This study is...

Zearalenone (ZEN) is a non-steroidal estrogenic mycotoxin that adversely affects directly exposed individuals, yet the intergenerational consequences of paternal ZEN exposure remain poorly understood. In this study, we investigated the impact of pate...

Ultraviolet (UV) exposure accelerates skin aging by inducing oxidative stress, extracellular matrix (ECM) degradation, and epidermal barrier dysfunction. This study investigated the protective effects of Brazilian pepper tree (SB), neem (SD), and Vie...

Urothelial carcinoma (UC) of the bladder exhibits low- and high-grade papillary forms with distinct prognoses. High mobility group proteins (HMGA1, HMGA2, HMGB1) and miR-106a-5p are involved in tumor progression, but their interplay in UC remains inc...

Glycine N-methyltransferase (GNMT), a S-adenosylmethionine (SAM)-dependent methyltransferase, is primarily expressed in the liver and plays a key role in regulating liver metabolism and protecting against liver injury. Several studies have shown that...

Cleft palate only (CPO) is a multifactorial craniofacial malformation with significant genetic and epigenetic contributions. Among these, microRNAs (miRNAs) have emerged as key regulators of palate development, although their alterations in CPO remai...

Metal oxides such as TiO₂, ZnO, and BiVO₄ have emerged as pivotal materials for renewable energy technologies owing to their versatile electronic, optical, and catalytic properties. This review highlights the importance of bridging experimental inves...

Leptospirosis is a widespread zoonosis of human and veterinary concern. The etiological agent of the disease is the pathogenic bacteria of the genus Leptospira. Transmission typically occurs through mucosal contact and/or injured skin with the urine...