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A Genome-Wide Association Study and Complex Network Identify Four Core Hub Genes in Bipolar Disorder

Institute of Bioinformatics, Chongqing University of Posts and Telecommunications, Chongqing 400065, China
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2017, 18(12), 2763;
Received: 23 October 2017 / Revised: 29 November 2017 / Accepted: 14 December 2017 / Published: 19 December 2017
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Bipolar disorder is a common and severe mental illness with unsolved pathophysiology. A genome-wide association study (GWAS) has been used to find a number of risk genes, but it is difficult for a GWAS to find genes indirectly associated with a disease. To find core hub genes, we introduce a network analysis after the GWAS was conducted. Six thousand four hundred fifty eight single nucleotide polymorphisms (SNPs) with p < 0.01 were sifted out from Wellcome Trust Case Control Consortium (WTCCC) dataset and mapped to 2045 genes, which are then compared with the protein–protein network. One hundred twelve genes with a degree >17 were chosen as hub genes from which five significant modules and four core hub genes (FBXL13, WDFY2, bFGF, and MTHFD1L) were found. These core hub genes have not been reported to be directly associated with BD but may function by interacting with genes directly related to BD. Our method engenders new thoughts on finding genes indirectly associated with, but important for, complex diseases. View Full-Text
Keywords: bipolar disorder; GWAS; functional enrichment analysis; network analysis bipolar disorder; GWAS; functional enrichment analysis; network analysis

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Xie, Z.; Yang, X.; Deng, X.; Ma, M.; Shu, K. A Genome-Wide Association Study and Complex Network Identify Four Core Hub Genes in Bipolar Disorder. Int. J. Mol. Sci. 2017, 18, 2763.

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