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Int. J. Mol. Sci. 2017, 18(12), 2725;

IFN-β: A Contentious Player in Host–Pathogen Interaction in Tuberculosis

State Key Laboratories for Agrobiotechnology, Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China
Author to whom correspondence should be addressed.
Received: 14 November 2017 / Revised: 8 December 2017 / Accepted: 12 December 2017 / Published: 16 December 2017
(This article belongs to the Special Issue Macrophages in Inflammation)
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Tuberculosis (TB) is a major health threat to the human population worldwide. The etiology of the disease is Mycobacterium tuberculosis (Mtb), a highly successful intracellular pathogen. It has the ability to manipulate the host immune response and to make the intracellular environment suitable for its survival. Many studies have addressed the interactions between the bacteria and the host immune cells as involving many immune mediators and other cellular players. Interferon-β (IFN-β) signaling is crucial for inducing the host innate immune response and it is an important determinant in the fate of mycobacterial infection. The role of IFN-β in protection against viral infections is well established and has been studied for decades, but its role in mycobacterial infections remains much more complicated and debatable. The involvement of IFN-β in immune evasion mechanisms adopted by Mtb has been an important area of investigation in recent years. These advances have widened our understanding of the pro-bacterial role of IFN-β in host–pathogen interactions. This pro-bacterial activity of IFN-β appears to be correlated with its anti-inflammatory characteristics, primarily by antagonizing the production and function of interleukin 1β (IL-1β) and interleukin 18 (IL-18) through increased interleukin 10 (IL-10) production and by inhibiting the nucleotide-binding domain and leucine-rich repeat protein-3 (NLRP3) inflammasome. Furthermore, it also fails to provoke a proper T helper 1 (Th1) response and reduces the expression of major histocompatibility complex II (MHC-II) and interferon-γ receptors (IFNGRs). Here we will review some studies to provide a paradigm for the induction, regulation, and role of IFN-β in mycobacterial infection. Indeed, recent studies suggest that IFN-β plays a role in Mtb survival in host cells and its downregulation may be a useful therapeutic strategy to control Mtb infection. View Full-Text
Keywords: Mycobacterium tuberculosis (Mtb); interferon-β (IFN-β); nucleotide-binding domain and leucine-rich repeat protein-3 (NLRP3); interleukin-1β (IL-1β); fate of infection Mycobacterium tuberculosis (Mtb); interferon-β (IFN-β); nucleotide-binding domain and leucine-rich repeat protein-3 (NLRP3); interleukin-1β (IL-1β); fate of infection

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Sabir, N.; Hussain, T.; Shah, S.Z.A.; Zhao, D.; Zhou, X. IFN-β: A Contentious Player in Host–Pathogen Interaction in Tuberculosis. Int. J. Mol. Sci. 2017, 18, 2725.

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