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Molecules, Volume 25, Issue 15

2020 August-1 - 245 articles

Cover Story: The control of the mosquito Aedes aegypti is a required strategy to reduce arboviral diseases such as dengue, Zika and chikungunya. Considering the high toxicity of commonly used chemical synthetic insecticides and even the resistance of mosquito, plant natural products have demonstrated interesting insecticidal applications with advantages over synthetic ones. In this review, we describe botanical species and secondary metabolites with insecticidal activities in different stages of the insect development, as well as some of their mechanism of action. In addition, we discuss the challenges to develop more eco-friendly insecticides having botanical sources as suitable alternative to control the Ae. aegypti. View this paper.
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Articles (245)

  • Article
  • Open Access
23 Citations
4,907 Views
14 Pages

4 August 2020

The development of high-performance sensors is of great significance for the control of the volatile organic compounds (VOCs) pollution and their potential hazard. In this paper, high crystalline V2O5 nanoparticles were successfully synthesized by a...

  • Article
  • Open Access
20 Citations
5,715 Views
13 Pages

Effects of Thymus vulgaris L., Cinnamomum verum J.Presl and Cymbopogon nardus (L.) Rendle Essential Oils in the Endotoxin-induced Acute Airway Inflammation Mouse Model

  • Eszter Csikós,
  • Kata Csekő,
  • Amir Reza Ashraf,
  • Ágnes Kemény,
  • László Kereskai,
  • Béla Kocsis,
  • Andrea Böszörményi,
  • Zsuzsanna Helyes and
  • Györgyi Horváth

4 August 2020

Thyme (TO), cinnamon (CO), and Ceylon type lemongrass (LO) essential oils (EOs) are commonly used for inhalation. However, their effects and mechanisms on inflammatory processes are not well-documented, and the number of in vivo data that would be im...

  • Article
  • Open Access
24 Citations
5,604 Views
22 Pages

Genoprotective Properties and Metabolites of β-Glucan-Rich Edible Mushrooms Following Their In Vitro Fermentation by Human Faecal Microbiota

  • Athina Boulaka,
  • Paris Christodoulou,
  • Marigoula Vlassopoulou,
  • Georgios Koutrotsios,
  • Georgios Bekiaris,
  • Georgios I. Zervakis,
  • Evdokia K. Mitsou,
  • Georgia Saxami,
  • Adamantini Kyriacou and
  • Vasiliki Pletsa
  • + 2 authors

4 August 2020

A variety of bioactive compounds, constituents of edible mushrooms, in particular β-glucans, i.e., a group of β-d-glucose polysaccharides abundant in the fungal cell walls, have been linked to immunomodulating, anticancer and prebiotic activities. Th...

  • Review
  • Open Access
19 Citations
6,081 Views
24 Pages

4 August 2020

Since the discovery of fullerene, carbon-based nanomolecules sparked a wealth of research across biological, medical and material sciences. Understanding the interactions of these materials with biological samples at the atomic level is crucial for i...

  • Communication
  • Open Access
20 Citations
5,005 Views
11 Pages

Far-Off Resonance: Multiwavelength Raman Spectroscopy Probing Amide Bands of Amyloid-β-(37–42) Peptide

  • Martynas Talaikis,
  • Simona Strazdaitė,
  • Mantas Žiaunys and
  • Gediminas Niaura

4 August 2020

Several neurodegenerative diseases, like Alzheimer’s and Parkinson’s are linked with protein aggregation into amyloid fibrils. Conformational changes of native protein into the β-sheet structure are associated with a significant chan...

  • Article
  • Open Access
34 Citations
5,359 Views
19 Pages

Facile Fabrication of Natural Polyelectrolyte-Nanoclay Composites: Halloysite Nanotubes, Nucleotides and DNA Study

  • Svetlana Batasheva,
  • Marina Kryuchkova,
  • Ramil Fakhrullin,
  • Giuseppe Cavallaro,
  • Giuseppe Lazzara,
  • Farida Akhatova,
  • Läysän Nigamatzyanova,
  • Vladimir Evtugyn,
  • Elvira Rozhina and
  • Rawil Fakhrullin

4 August 2020

Complexation of biopolymers with halloysite nanotubes (HNTs) can greatly affect their applicability as materials building blocks. Here we have performed a systematic investigation of fabrication of halloysite nanotubes complexes with nucleotides and...

  • Article
  • Open Access
16 Citations
7,153 Views
29 Pages

Synthesis and Biological Activity of New 7-Amino-oxazolo[5,4-d]Pyrimidine Derivatives

  • Aleksandra Sochacka-Ćwikła,
  • Andrzej Regiec,
  • Michał Zimecki,
  • Jolanta Artym,
  • Ewa Zaczyńska,
  • Maja Kocięba,
  • Iwona Kochanowska,
  • Iwona Bryndal,
  • Anna Pyra and
  • Marcin Mączyński

4 August 2020

The synthesis of a series of novel 7-aminooxazolo[5,4-d]pyrimidines 5, transformations during their synthesis and their physicochemical characteristics have been described. Complete detailed spectral analysis of the intermediates 24, the N&pri...

  • Article
  • Open Access
40 Citations
5,255 Views
16 Pages

3 August 2020

As a remedy for environmental pollution, a versatile synthetic approach has been developed to prepare polyvinyl alcohol (PVA)/nitrogen-doped carbon dots (CDs) composite film (PVA-CDs) for removal of toxic cadmium ions. The CDs were first synthesized...

  • Review
  • Open Access
29 Citations
5,875 Views
39 Pages

3 August 2020

Nanobioconjugates are hybrid materials that result from the coalescence of biomolecules and nanomaterials. They have emerged as a strategy to amplify the signal response in the biosensor field with the potential to enhance the sensitivity and detecti...

  • Article
  • Open Access
12 Citations
4,252 Views
19 Pages

3 August 2020

Green petroleum coke, a form of industrial waste produced in the oil-refining process, was used to synthesize nitrogen-doped graphene-like plates (N-GLPs) together with melamine. In this study, characterization and batch experiments were performed to...

  • Feature Paper
  • Article
  • Open Access
17 Citations
4,871 Views
15 Pages

The Bioaccessibility of Antioxidants in Black Currant Puree after High Hydrostatic Pressure Treatment

  • Urszula Trych,
  • Magdalena Buniowska,
  • Sylwia Skąpska,
  • Szymon Starzonek and
  • Krystian Marszałek

3 August 2020

The aim of the study was to investigate the effect of high-pressure processing (HPP) and thermal processing (TP) on the bioaccessibility of vitamin C and anthocyanins as well as changes in the antioxidant capacity (AC) using ABTS+• and DPPH• tests on...

  • Article
  • Open Access
47 Citations
7,779 Views
20 Pages

Streptomyces sp. Strain MUSC 125 from Mangrove Soil in Malaysia with Anti-MRSA, Anti-Biofilm and Antioxidant Activities

  • Hefa Mangzira Kemung,
  • Loh Teng-Hern Tan,
  • Kok-Gan Chan,
  • Hooi-Leng Ser,
  • Jodi Woan-Fei Law,
  • Learn-Han Lee and
  • Bey-Hing Goh

3 August 2020

There is an urgent need to search for new antibiotics to counter the growing number of antibiotic-resistant bacterial strains, one of which is methicillin-resistant Staphylococcus aureus (MRSA). Herein, we report a Streptomyces sp. strain MUSC 125 fr...

  • Article
  • Open Access
18 Citations
4,235 Views
13 Pages

The Influence of Anthocyanidin Profile on Antileishmanial Activity of Arrabidaea chica Morphotypes

  • Carla Junqueira Moragas-Tellis,
  • Fernando Almeida-Souza,
  • Maria do Socorro dos Santos Chagas,
  • Paulo Victor Ramos de Souza,
  • João Victor Silva-Silva,
  • Ygor Jessé Ramos,
  • Davyson de Lima Moreira,
  • Kátia da Silva Calabrese and
  • Maria Dutra Behrens

3 August 2020

Arrabidaea chica Verlot (crajiru) is a plant used in folk medicine as an astringent, anti-inflammatory, wound healing and to treat fungal and viral diseases such as measles chickenpox and herpes. Arrabidaea chica has several morphotypes recognized bu...

  • Article
  • Open Access
21 Citations
6,130 Views
14 Pages

Towards a Valorization of Corn Bioethanol Side Streams: Chemical Characterization of Post Fermentation Corn Oil and Thin Stillage

  • Gabriella Di Lena,
  • Petra Ondrejíčková,
  • Josè Sanchez del Pulgar,
  • Veronika Cyprichová,
  • Tomáš Ježovič,
  • Massimo Lucarini,
  • Ginevra Lombardi Boccia,
  • Stefano Ferrari Nicoli,
  • Paolo Gabrielli and
  • Roberto Caproni
  • + 2 authors

3 August 2020

First-generation biofuel biorefineries may be a starting point for the development of new value chains, as their by-products and side streams retain nutrients and valuable molecules that may be recovered and valorized for high-value applications. Thi...

  • Article
  • Open Access
17 Citations
5,680 Views
13 Pages

Antidepressant Effect of Shaded White Leaf Tea Containing High Levels of Caffeine and Amino Acids

  • Keiko Unno,
  • Daisuke Furushima,
  • Yuzuki Nomura,
  • Hiroshi Yamada,
  • Kazuaki Iguchi,
  • Kyoko Taguchi,
  • Toshikazu Suzuki,
  • Makoto Ozeki and
  • Yoriyuki Nakamura

3 August 2020

The young leaves of green tea become lighter in color than usual when protected from sunlight by a shading net for about two weeks while growing. These leaves are called “shaded white leaf tea” or SWLT. In the eluate of SWLT, the amount o...

  • Article
  • Open Access
20 Citations
5,292 Views
14 Pages

Synthesis and Pharmacological Effects of Diosgenin–Betulinic Acid Conjugates

  • Zülal Özdemir,
  • Michaela Rybková,
  • Martin Vlk,
  • David Šaman,
  • Lucie Rárová and
  • Zdeněk Wimmer

3 August 2020

The target diosgenin–betulinic acid conjugates are reported to investigate their ability to enhance and modify the pharmacological effects of their components. The detailed synthetic procedure that includes copper(I)-catalyzed Huisgen 1,3-dipol...

  • Article
  • Open Access
2 Citations
4,311 Views
27 Pages

Chemometric Models of Differential Amino Acids at the Navα and Navβ Interface of Mammalian Sodium Channel Isoforms

  • Fernando Villa-Diaz,
  • Susana Lopez-Nunez,
  • Jordan E. Ruiz-Castelan,
  • Eduardo Marcos Salinas-Stefanon and
  • Thomas Scior

3 August 2020

(1) Background: voltage-gated sodium channels (Navs) are integral membrane proteins that allow the sodium ion flux into the excitable cells and initiate the action potential. They comprise an α (Navα) subunit that forms the channel pore a...

  • Article
  • Open Access
1 Citations
4,637 Views
12 Pages

3 August 2020

Benzoin is one of the most commonly used photoinitiators to induce free radical polymerization. Here, improved benzoin properties could be accomplished by the introduction of two methoxy substituents, leading to the formation of 3’,5’-dim...

  • Feature Paper
  • Article
  • Open Access
27 Citations
5,031 Views
16 Pages

2 August 2020

In this work, dewatered waste activated sludge (DWAS) was subjected to hydrothermal carbonization to obtain hydrochars that can be used as renewable solid fuels or activated carbon precursors. A central composite rotatable design was used to analyze...

  • Feature Paper
  • Article
  • Open Access
23 Citations
4,785 Views
14 Pages

Viscosified Solid Lipidic Nanoparticles Based on Naringenin and Linolenic Acid for the Release of Cyclosporine A on the Skin

  • Sonia Trombino,
  • Camilla Servidio,
  • Annarita Stella Laganà,
  • Filomena Conforti,
  • Mariangela Marrelli and
  • Roberta Cassano

2 August 2020

Psoriasis is one of the most common human skin disorders. Although its pathogenesis is complex and not completely know, the hyperactivation of the immune system seem to have a key role. In this regard, among the most effective systemic therapeutics u...

  • Article
  • Open Access
57 Citations
10,285 Views
29 Pages

GC-MS Phytochemical Profiling, Pharmacological Properties, and In Silico Studies of Chukrasia velutina Leaves: A Novel Source for Bioactive Agents

  • Israt Jahan,
  • Marzia Rahman Tona,
  • Sanjida Sharmin,
  • Mohammed Aktar Sayeed,
  • Fatamatuz Zuhura Tania,
  • Arkajyoti Paul,
  • Md. Nazim Uddin Chy,
  • Ahmed Rakib,
  • Talha Bin Emran and
  • Jesus Simal-Gandara

2 August 2020

Chukrasia velutina is a local medicinal plant commonly known as chikrassy in Bangladesh, India, China, and other South Asian countries. The leaves, bark, and seeds are vastly used as herbal medicine for fever and diarrhea, and its leaves essential oi...

  • Review
  • Open Access
172 Citations
20,265 Views
25 Pages

2 August 2020

Wood is a renewable, versatile material with multiple applications and the largest terrestrial pool of sequestered carbon. However, it is susceptible to degradation, mainly caused by wood-decaying fungi. Since several traditional wood preservatives h...

  • Article
  • Open Access
38 Citations
7,171 Views
20 Pages

Dissolving Cellulose in 1,2,3-Triazolium- and Imidazolium-Based Ionic Liquids with Aromatic Anions

  • Martin Brehm,
  • Julian Radicke,
  • Martin Pulst,
  • Farzaneh Shaabani,
  • Daniel Sebastiani and
  • Jörg Kressler

2 August 2020

We present 1,2,3-triazolium- and imidazolium-based ionic liquids (ILs) with aromatic anions as a new class of cellulose solvents. The two anions in our study, benzoate and salicylate, possess a lower basicity when compared to acetate and therefore sh...

  • Feature Paper
  • Article
  • Open Access
30 Citations
6,611 Views
26 Pages

Spin Density Topology

  • Giovanna Bruno,
  • Giovanni Macetti,
  • Leonardo Lo Presti and
  • Carlo Gatti

2 August 2020

Despite its role in spin density functional theory and it being the basic observable for describing and understanding magnetic phenomena, few studies have appeared on the electron spin density subtleties thus far. A systematic full topological analys...

  • Article
  • Open Access
20 Citations
6,204 Views
16 Pages

New Series of Double-Modified Colchicine Derivatives: Synthesis, Cytotoxic Effect and Molecular Docking

  • Julia Krzywik,
  • Maral Aminpour,
  • Ewa Maj,
  • Witold Mozga,
  • Joanna Wietrzyk,
  • Jack A. Tuszyński and
  • Adam Huczyński

2 August 2020

Colchicine is a well-known anticancer compound showing antimitotic effect on cells. Its high cytotoxic activity against different cancer cell lines has been demonstrated many times. In this paper we report the syntheses and spectroscopic analyses of...

  • Article
  • Open Access
7 Citations
4,038 Views
11 Pages

Constituents of Huberantha jenkinsii and Their Biological Activities

  • Htoo Tint San,
  • Tanawat Chaowasku,
  • Wanwimon Mekboonsonglarp,
  • Ratchanee Rodsiri,
  • Boonchoo Sritularak,
  • Hathairat Buraphaka,
  • Waraporn Putalun and
  • Kittisak Likhitwitayawuid

2 August 2020

The phytochemical investigation of Huberantha jenkinsii resulted in the isolation of two new and five known compounds. The new compounds were characterized as undescribed 8-oxoprotoberberine alkaloids and named huberanthines A and B, whereas the know...

  • Article
  • Open Access
8 Citations
4,234 Views
11 Pages

1 August 2020

Tetracycline (TET) has been widely used in the treatment of Streptococcus suis (S. suis) infection. However, it was found that the efficacy of many antibiotics in S. suis decreased significantly, especially tetracycline. In this study, GML-12 (a nove...

  • Review
  • Open Access
105 Citations
33,103 Views
16 Pages

Cranberry Polyphenols and Prevention against Urinary Tract Infections: Relevant Considerations

  • Dolores González de Llano,
  • M. Victoria Moreno-Arribas and
  • Begoña Bartolomé

1 August 2020

Cranberry (Vaccinium macrocarpon) is a distinctive source of polyphenols as flavonoids and phenolic acids that has been described to display beneficial effects against urinary tract infections (UTIs), the second most common type of infections worldwi...

  • Article
  • Open Access
11 Citations
3,325 Views
11 Pages

Analysis of the Effect of the Biomass Torrefaction Process on Selected Parameters of Dust Explosivity

  • Marcin Bajcar,
  • Bogdan Saletnik,
  • Grzegorz Zaguła and
  • Czesław Puchalski

1 August 2020

This article presents the findings of a study investigating the explosion and combustion parameters of dust from the raw biomass of wheat straw and energy willow and from the products of biomass torrefaction generated at temperatures ranging from 220...

  • Article
  • Open Access
3 Citations
3,826 Views
11 Pages

1 August 2020

The aggregation process of the Amyloidβ (Aβ) peptide is one of the central questions in Alzheimers’s research. Fluorescence-labeled single-molecule detection is a novel technique concerning the early stage investigation of Aβ agg...

  • Article
  • Open Access
12 Citations
4,726 Views
21 Pages

The Spectrum of Design Solutions for Improving the Activity-Selectivity Product of Peptide Antibiotics against Multidrug-Resistant Bacteria and Prostate Cancer PC-3 Cells

  • Davor Juretić,
  • Anja Golemac,
  • Denise E. Strand,
  • Keshi Chung,
  • Nada Ilić,
  • Ivana Goić-Barišić and
  • François-Xavier Pellay

1 August 2020

The link between the antimicrobial and anticancer activity of peptides has long been studied, and the number of peptides identified with both activities has recently increased considerably. In this work, we hypothesized that designed peptides with a...

  • Review
  • Open Access
28 Citations
5,612 Views
13 Pages

Invasive Plants: Turning Enemies into Value

  • Patrícia Máximo,
  • Luísa M. Ferreira,
  • Paula S. Branco and
  • Ana Lourenço

1 August 2020

In this review, a brief description of the invasive phenomena associated with plants and its consequences to the ecosystem is presented. Five worldwide invasive plants that are a threat to Portugal were selected as an example, and a brief description...

  • Article
  • Open Access
25 Citations
5,315 Views
18 Pages

Flavonoids and Terpenoids with PTP-1B Inhibitory Properties from the Infusion of Salvia amarissima Ortega

  • Eric Salinas-Arellano,
  • Araceli Pérez-Vásquez,
  • Isabel Rivero-Cruz,
  • Rafael Torres-Colin,
  • Martín González-Andrade,
  • Manuel Rangel-Grimaldo and
  • Rachel Mata

1 August 2020

An infusion prepared from the aerial parts of Salvia amarissima Ortega inhibited the enzyme protein tyrosine phosphatase 1B (PTP-1B) (IC50~88 and 33 μg/mL, respectively). Phytochemical analysis of the infusion yielded amarisolide (1), 5,6,4′...

  • Article
  • Open Access
44 Citations
5,631 Views
13 Pages

Identification of Polyphenols from Coniferous Shoots as Natural Antioxidants and Antimicrobial Compounds

  • Marcin Dziedzinski,
  • Joanna Kobus-Cisowska,
  • Daria Szymanowska,
  • Kinga Stuper-Szablewska and
  • Marlena Baranowska

1 August 2020

Currently, coniferous shoots are almost absent as a food ingredient despite their wide availability in many parts of the world. The aim of the study was to assess and compare the composition of selected plant metabolites, evaluate the antioxidant and...

  • Review
  • Open Access
50 Citations
10,404 Views
33 Pages

Bioactive Compounds and Metabolites from Grapes and Red Wine in Breast Cancer Chemoprevention and Therapy

  • Danielly C. Ferraz da Costa,
  • Luciana Pereira Rangel,
  • Julia Quarti,
  • Ronimara A. Santos,
  • Jerson L. Silva and
  • Eliane Fialho

1 August 2020

Phytochemicals and their metabolites are not considered essential nutrients in humans, although an increasing number of well-conducted studies are linking their higher intake with a lower incidence of non-communicable diseases, including cancer. This...

  • Article
  • Open Access
74 Citations
7,007 Views
21 Pages

Bioactive Compounds, Antioxidant Activity, and Antinutritional Content of Legumes: A Comparison between Four Phaseolus Species

  • Montserrat Alcázar-Valle,
  • Eugenia Lugo-Cervantes,
  • Luis Mojica,
  • Norma Morales-Hernández,
  • Heidy Reyes-Ramírez,
  • Jhony Navat Enríquez-Vara and
  • Soledad García-Morales

1 August 2020

Beans (Phaseolus spp.) are one of the most important legumes for their nutritional value and health benefits in many world regions. In addition to Phaseolus vulgaris, there are four additional species that are cultivated in many regions of the world...

  • Review
  • Open Access
44 Citations
10,611 Views
33 Pages

1 August 2020

In the field of gas separation and purification, membrane technologies compete with conventional purification processes on the basis of technical, economic and environmental factors. In this context, there is a growing interest in the development of...

  • Article
  • Open Access
75 Citations
6,356 Views
17 Pages

Fractionation of Biomolecules in Withania coagulans Extract for Bioreductive Nanoparticle Synthesis, Antifungal and Biofilm Activity

  • Murtaza Hasan,
  • Ayesha Zafar,
  • Irum Shahzadi,
  • Fan Luo,
  • Shahbaz Gul Hassan,
  • Tuba Tariq,
  • Sadaf Zehra,
  • Tauseef Munawar,
  • Faisal Iqbal and
  • Xugang Shu

31 July 2020

Withania coagulans contains a complex mixture of various bioactive compounds. In order to reduce the complexity of the plant extract to purify its phytochemical biomolecules, a novel fractionation strategy using different solvent combination ratios w...

  • Article
  • Open Access
13 Citations
5,035 Views
16 Pages

Cocaine Self-Administration and Abstinence Modulate NMDA Receptor Subunits and Active Zone Proteins in the Rat Nucleus Accumbens

  • Irena Smaga,
  • Karolina Wydra,
  • Małgorzata Frankowska,
  • Fabio Fumagalli,
  • Marek Sanak and
  • Małgorzata Filip

31 July 2020

Cocaine-induced plasticity in the glutamatergic transmission and its N-methyl-d-aspartate (NMDA) receptors are critically involved in the development of substance use disorder. The presynaptic active zone proteins control structural synaptic plastici...

  • Article
  • Open Access
35 Citations
5,791 Views
23 Pages

Chemo-Protective Potential of Cerium Oxide Nanoparticles against Fipronil-Induced Oxidative Stress, Apoptosis, Inflammation and Reproductive Dysfunction in Male White Albino Rats

  • Hamida Saleh,
  • Atef M. K. Nassar,
  • Ahmed E. Noreldin,
  • Dalia Samak,
  • Norhan Elshony,
  • Lamiaa Wasef,
  • Yaser H. A. Elewa,
  • Shaimaa M. A. Hassan,
  • Abdullah A. Saati and
  • Yasser S. El-Sayed
  • + 4 authors

31 July 2020

Fipronil (FIP) is an insecticide commonly used in many fields, such as agriculture, veterinary medicine, and public health, and recently it has been proposed as a potential endocrine disrupter. The purpose of this study was to inspect the reproductiv...

  • Feature Paper
  • Article
  • Open Access
31 Citations
5,102 Views
13 Pages

31 July 2020

Honey is a natural food widely consumed due to its high content in nutrients and bioactive substances. In order to prevent hive infections, xenobiotics such as pesticides and antibiotics are commonly used. Chloramphenicol (CAP) is a broad-spectrum an...

  • Review
  • Open Access
60 Citations
10,513 Views
37 Pages

Peptide-Based Nanoassemblies in Gene Therapy and Diagnosis: Paving the Way for Clinical Application

  • Shabnam Tarvirdipour,
  • Xinan Huang,
  • Voichita Mihali,
  • Cora-Ann Schoenenberger and
  • Cornelia G. Palivan

31 July 2020

Nanotechnology approaches play an important role in developing novel and efficient carriers for biomedical applications. Peptides are particularly appealing to generate such nanocarriers because they can be rationally designed to serve as building bl...

  • Review
  • Open Access
27 Citations
8,789 Views
18 Pages

31 July 2020

DNA, the fundamental genetic polymer of all living organisms on Earth, can be chemically modified to embrace novel functions that do not exist in nature. The key chemical and structural parameters for genetic information storage, heredity, and evolut...

  • Review
  • Open Access
112 Citations
18,016 Views
45 Pages

Plant Natural Products for the Control of Aedes aegypti: The Main Vector of Important Arboviruses

  • Maíra Rosato Silveiral Silvério,
  • Laila Salmen Espindola,
  • Norberto Peporine Lopes and
  • Paulo Cézar Vieira

31 July 2020

The mosquito species Aedes aegypti is one of the main vectors of arboviruses, including dengue, Zika and chikungunya. Considering the deficiency or absence of vaccines to prevent these diseases, vector control remains an important strategy. The use o...

  • Article
  • Open Access
11 Citations
9,237 Views
12 Pages

31 July 2020

A non-empirical exchange functional based on an interpolation between two limits of electron density, slowly varying limit and asymptotic limit, is proposed. In the slowly varying limit, we follow the study by Kleinman from 1984 which considered the...

  • Article
  • Open Access
23 Citations
4,113 Views
14 Pages

Application of Nanoemulsions (W/O) of Extract of Opuntia oligacantha C.F. Först and Orange Oil in Gelatine Films

  • Salvador Omar Espino-Manzano,
  • Arely León-López,
  • Gabriel Aguirre-Álvarez,
  • Uriel González-Lemus,
  • Laurette Prince and
  • Rafael Germán Campos-Montiel

31 July 2020

Over the past decade, consumers have demanded natural, completely biodegradable active packaging serving as food containers. Bioactive plant compounds can be added to biopolymer-based films to improve their functionality, as they not only act as barr...

  • Article
  • Open Access
40 Citations
5,776 Views
26 Pages

31 July 2020

In this study, a novel hybrid surrogate machine learning model based on a feedforward neural network (FNN) and one step secant algorithm (OSS) was developed to predict the load-bearing capacity of concrete-filled steel tube columns (CFST), whereas th...

  • Article
  • Open Access
10 Citations
6,878 Views
22 Pages

31 July 2020

Focal adhesion kinase (FAK) is a tyrosine kinase that is overexpressed and activated in several advanced-stage solid cancers. In cancer cells, FAK promotes the progression and metastasis of tumours. In this study, we used structure-based virtual scre...

  • Review
  • Open Access
43 Citations
6,818 Views
23 Pages

Gold Nanoparticles for Vectorization of Nucleic Acids for Cancer Therapeutics

  • Daniela Ferreira,
  • David Fontinha,
  • Catarina Martins,
  • David Pires,
  • Alexandra R. Fernandes and
  • Pedro V. Baptista

31 July 2020

Cancer remains a complex medical challenge and one of the leading causes of death worldwide. Nanomedicines have been proposed as innovative platforms to tackle these complex diseases, where the combination of several treatment strategies might enhanc...

  • Review
  • Open Access
17 Citations
6,370 Views
37 Pages

31 July 2020

Water radical cations, (H2O)n+•, are of great research interest in both fundamental and applied sciences. Fundamental studies of water radical reactions are important to better understand the mechanisms of natural processes, such as proton trans...

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