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Molecules, Volume 25, Issue 15

2020 August-1 - 245 articles

Cover Story: The control of the mosquito Aedes aegypti is a required strategy to reduce arboviral diseases such as dengue, Zika and chikungunya. Considering the high toxicity of commonly used chemical synthetic insecticides and even the resistance of mosquito, plant natural products have demonstrated interesting insecticidal applications with advantages over synthetic ones. In this review, we describe botanical species and secondary metabolites with insecticidal activities in different stages of the insect development, as well as some of their mechanism of action. In addition, we discuss the challenges to develop more eco-friendly insecticides having botanical sources as suitable alternative to control the Ae. aegypti. View this paper.
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Articles (245)

  • Article
  • Open Access
26 Citations
5,454 Views
14 Pages

4 August 2020

The development of high-performance sensors is of great significance for the control of the volatile organic compounds (VOCs) pollution and their potential hazard. In this paper, high crystalline V2O5 nanoparticles were successfully synthesized by a...

(This article belongs to the Section Analytical Chemistry)
  • Article
  • Open Access
22 Citations
6,329 Views
13 Pages

Effects of Thymus vulgaris L., Cinnamomum verum J.Presl and Cymbopogon nardus (L.) Rendle Essential Oils in the Endotoxin-induced Acute Airway Inflammation Mouse Model

  • Eszter Csikós,
  • Kata Csekő,
  • Amir Reza Ashraf,
  • Ágnes Kemény and ,
  • László Kereskai,
  • Béla Kocsis,
  • Andrea Böszörményi,
  • Zsuzsanna Helyes and
  • Györgyi Horváth
  • + 4 authors+ 0 author

4 August 2020

Thyme (TO), cinnamon (CO), and Ceylon type lemongrass (LO) essential oils (EOs) are commonly used for inhalation. However, their effects and mechanisms on inflammatory processes are not well-documented, and the number of in vivo data that would be im...

(This article belongs to the Special Issue The Therapeutic Potential of Naturally Occurring Compounds in Counteracting Oxidative Stress and Inflammation: From Basic Science to Therapy)
  • Article
  • Open Access
24 Citations
6,127 Views
22 Pages

Genoprotective Properties and Metabolites of β-Glucan-Rich Edible Mushrooms Following Their In Vitro Fermentation by Human Faecal Microbiota

  • Athina Boulaka,
  • Paris Christodoulou,
  • Marigoula Vlassopoulou,
  • Georgios Koutrotsios and ,
  • Georgios Bekiaris,
  • Georgios I. Zervakis,
  • Evdokia K. Mitsou,
  • Georgia Saxami,
  • Adamantini Kyriacou and
  • Vasiliki Pletsa
  • + 7 authors+ 2 authors

4 August 2020

A variety of bioactive compounds, constituents of edible mushrooms, in particular β-glucans, i.e., a group of β-d-glucose polysaccharides abundant in the fungal cell walls, have been linked to immunomodulating, anticancer and prebiotic activities. Th...

(This article belongs to the Special Issue Mushrooms:The Versatile Roles)
  • Review
  • Open Access
19 Citations
6,494 Views
24 Pages

4 August 2020

Since the discovery of fullerene, carbon-based nanomolecules sparked a wealth of research across biological, medical and material sciences. Understanding the interactions of these materials with biological samples at the atomic level is crucial for i...

(This article belongs to the Special Issue Frontier of Protein Crystallography)
  • Communication
  • Open Access
22 Citations
5,465 Views
11 Pages

Far-Off Resonance: Multiwavelength Raman Spectroscopy Probing Amide Bands of Amyloid-β-(37–42) Peptide

  • Martynas Talaikis,
  • Simona Strazdaitė,
  • Mantas Žiaunys and
  • Gediminas Niaura

4 August 2020

Several neurodegenerative diseases, like Alzheimer’s and Parkinson’s are linked with protein aggregation into amyloid fibrils. Conformational changes of native protein into the β-sheet structure are associated with a significant chan...

(This article belongs to the Special Issue Vibrational Spectroscopy as a Versatile Tool To Predict Protein Structure)
  • Article
  • Open Access
34 Citations
5,699 Views
19 Pages

Facile Fabrication of Natural Polyelectrolyte-Nanoclay Composites: Halloysite Nanotubes, Nucleotides and DNA Study

  • Svetlana Batasheva,
  • Marina Kryuchkova,
  • Ramil Fakhrullin,
  • Giuseppe Cavallaro and ,
  • Giuseppe Lazzara,
  • Farida Akhatova,
  • Läysän Nigamatzyanova,
  • Vladimir Evtugyn,
  • Elvira Rozhina and
  • Rawil Fakhrullin
  • + 5 authors+ 0 author

4 August 2020

Complexation of biopolymers with halloysite nanotubes (HNTs) can greatly affect their applicability as materials building blocks. Here we have performed a systematic investigation of fabrication of halloysite nanotubes complexes with nucleotides and...

(This article belongs to the Special Issue Recent Research Advance in the Halloysite Nanotubes Field)
  • Article
  • Open Access
16 Citations
7,655 Views
29 Pages

Synthesis and Biological Activity of New 7-Amino-oxazolo[5,4-d]Pyrimidine Derivatives

  • Aleksandra Sochacka-Ćwikła,
  • Andrzej Regiec,
  • Michał Zimecki,
  • Jolanta Artym and ,
  • Ewa Zaczyńska,
  • Maja Kocięba,
  • Iwona Kochanowska,
  • Iwona Bryndal,
  • Anna Pyra and
  • Marcin Mączyński
  • + 5 authors+ 0 author

4 August 2020

The synthesis of a series of novel 7-aminooxazolo[5,4-d]pyrimidines 5, transformations during their synthesis and their physicochemical characteristics have been described. Complete detailed spectral analysis of the intermediates 2–4, the N&pri...

(This article belongs to the Section Medicinal Chemistry)
  • Article
  • Open Access
45 Citations
5,708 Views
16 Pages

3 August 2020

As a remedy for environmental pollution, a versatile synthetic approach has been developed to prepare polyvinyl alcohol (PVA)/nitrogen-doped carbon dots (CDs) composite film (PVA-CDs) for removal of toxic cadmium ions. The CDs were first synthesized...

(This article belongs to the Special Issue Innovative Materials and Methods for the Removal of Pollutants from the Environment)
  • Review
  • Open Access
30 Citations
6,415 Views
39 Pages

3 August 2020

Nanobioconjugates are hybrid materials that result from the coalescence of biomolecules and nanomaterials. They have emerged as a strategy to amplify the signal response in the biosensor field with the potential to enhance the sensitivity and detecti...

(This article belongs to the Special Issue Nanochemistry: Good Beginnings for a Cross-Disciplinary Platform)
  • Article
  • Open Access
13 Citations
4,644 Views
19 Pages

3 August 2020

Green petroleum coke, a form of industrial waste produced in the oil-refining process, was used to synthesize nitrogen-doped graphene-like plates (N-GLPs) together with melamine. In this study, characterization and batch experiments were performed to...

  • Feature Paper
  • Article
  • Open Access
18 Citations
5,321 Views
15 Pages

The Bioaccessibility of Antioxidants in Black Currant Puree after High Hydrostatic Pressure Treatment

  • Urszula Trych,
  • Magdalena Buniowska,
  • Sylwia Skąpska,
  • Szymon Starzonek and
  • Krystian Marszałek

3 August 2020

The aim of the study was to investigate the effect of high-pressure processing (HPP) and thermal processing (TP) on the bioaccessibility of vitamin C and anthocyanins as well as changes in the antioxidant capacity (AC) using ABTS+• and DPPH• tests on...

(This article belongs to the Special Issue Bioactive Compounds of Fruits, Vegetables and Mushrooms)
  • Article
  • Open Access
51 Citations
8,279 Views
20 Pages

Streptomyces sp. Strain MUSC 125 from Mangrove Soil in Malaysia with Anti-MRSA, Anti-Biofilm and Antioxidant Activities

  • Hefa Mangzira Kemung,
  • Loh Teng-Hern Tan,
  • Kok-Gan Chan,
  • Hooi-Leng Ser and ,
  • Jodi Woan-Fei Law,
  • Learn-Han Lee and
  • Bey-Hing Goh
  • + 2 authors+ 0 author

3 August 2020

There is an urgent need to search for new antibiotics to counter the growing number of antibiotic-resistant bacterial strains, one of which is methicillin-resistant Staphylococcus aureus (MRSA). Herein, we report a Streptomyces sp. strain MUSC 125 fr...

(This article belongs to the Special Issue 25th Anniversary of Molecules—Recent Advances in Natural Products-2020)
  • Article
  • Open Access
20 Citations
4,569 Views
13 Pages

The Influence of Anthocyanidin Profile on Antileishmanial Activity of Arrabidaea chica Morphotypes

  • Carla Junqueira Moragas-Tellis,
  • Fernando Almeida-Souza,
  • Maria do Socorro dos Santos Chagas,
  • Paulo Victor Ramos de Souza and ,
  • João Victor Silva-Silva,
  • Ygor Jessé Ramos,
  • Davyson de Lima Moreira,
  • Kátia da Silva Calabrese and
  • Maria Dutra Behrens
  • + 4 authors+ 0 author

3 August 2020

Arrabidaea chica Verlot (crajiru) is a plant used in folk medicine as an astringent, anti-inflammatory, wound healing and to treat fungal and viral diseases such as measles chickenpox and herpes. Arrabidaea chica has several morphotypes recognized bu...

(This article belongs to the Section Natural Products Chemistry)
  • Article
  • Open Access
25 Citations
6,964 Views
14 Pages

Towards a Valorization of Corn Bioethanol Side Streams: Chemical Characterization of Post Fermentation Corn Oil and Thin Stillage

  • Gabriella Di Lena,
  • Petra Ondrejíčková,
  • Josè Sanchez del Pulgar,
  • Veronika Cyprichová and ,
  • Tomáš Ježovič,
  • Massimo Lucarini,
  • Ginevra Lombardi Boccia,
  • Stefano Ferrari Nicoli,
  • Paolo Gabrielli and
  • Roberto Caproni
  • + 7 authors+ 2 authors

3 August 2020

First-generation biofuel biorefineries may be a starting point for the development of new value chains, as their by-products and side streams retain nutrients and valuable molecules that may be recovered and valorized for high-value applications. Thi...

(This article belongs to the Special Issue Food Sustainability: Promising By-Products for Valorization)
  • Article
  • Open Access
17 Citations
6,147 Views
13 Pages

Antidepressant Effect of Shaded White Leaf Tea Containing High Levels of Caffeine and Amino Acids

  • Keiko Unno,
  • Daisuke Furushima,
  • Yuzuki Nomura,
  • Hiroshi Yamada and ,
  • Kazuaki Iguchi,
  • Kyoko Taguchi,
  • Toshikazu Suzuki,
  • Makoto Ozeki and
  • Yoriyuki Nakamura
  • + 4 authors+ 0 author

3 August 2020

The young leaves of green tea become lighter in color than usual when protected from sunlight by a shading net for about two weeks while growing. These leaves are called “shaded white leaf tea” or SWLT. In the eluate of SWLT, the amount o...

(This article belongs to the Special Issue Molecular Pharmacology of Green Tea)
  • Article
  • Open Access
21 Citations
5,735 Views
14 Pages

Synthesis and Pharmacological Effects of Diosgenin–Betulinic Acid Conjugates

  • Zülal Özdemir,
  • Michaela Rybková,
  • Martin Vlk,
  • David Šaman and ,
  • Lucie Rárová and
  • Zdeněk Wimmer
  • + 1 author+ 0 author

3 August 2020

The target diosgenin–betulinic acid conjugates are reported to investigate their ability to enhance and modify the pharmacological effects of their components. The detailed synthetic procedure that includes copper(I)-catalyzed Huisgen 1,3-dipol...

(This article belongs to the Special Issue Saponins: From Diversity to Structural Modification and Bioactive Responses in Model Systems)
  • Article
  • Open Access
2 Citations
4,626 Views
27 Pages

Chemometric Models of Differential Amino Acids at the Navα and Navβ Interface of Mammalian Sodium Channel Isoforms

  • Fernando Villa-Diaz,
  • Susana Lopez-Nunez,
  • Jordan E. Ruiz-Castelan,
  • Eduardo Marcos Salinas-Stefanon and
  • Thomas Scior

3 August 2020

(1) Background: voltage-gated sodium channels (Navs) are integral membrane proteins that allow the sodium ion flux into the excitable cells and initiate the action potential. They comprise an α (Navα) subunit that forms the channel pore a...

(This article belongs to the Section Computational and Theoretical Chemistry)
  • Article
  • Open Access
2 Citations
5,111 Views
12 Pages

Photochemical α-Cleavage Reaction of 3’,5’-Dimethoxybenzoin: A Combined Time-Resolved Spectroscopy and Computational Chemistry Study

  • Yuanchun Li,
  • Xiting Zhang,
  • Zhiping Yan,
  • Lili Du and ,
  • Wenjian Tang and
  • David Lee Phillips
  • + 1 author+ 0 author

3 August 2020

Benzoin is one of the most commonly used photoinitiators to induce free radical polymerization. Here, improved benzoin properties could be accomplished by the introduction of two methoxy substituents, leading to the formation of 3’,5’-dim...

(This article belongs to the Special Issue Practical Applications of Molecular Spectroscopy)
  • Article
  • Open Access
7 Citations
4,304 Views
11 Pages

Constituents of Huberantha jenkinsii and Their Biological Activities

  • Htoo Tint San,
  • Tanawat Chaowasku,
  • Wanwimon Mekboonsonglarp,
  • Ratchanee Rodsiri and ,
  • Boonchoo Sritularak,
  • Hathairat Buraphaka,
  • Waraporn Putalun and
  • Kittisak Likhitwitayawuid
  • + 3 authors+ 0 author

2 August 2020

The phytochemical investigation of Huberantha jenkinsii resulted in the isolation of two new and five known compounds. The new compounds were characterized as undescribed 8-oxoprotoberberine alkaloids and named huberanthines A and B, whereas the know...

(This article belongs to the Section Natural Products Chemistry)
  • Feature Paper
  • Article
  • Open Access
29 Citations
5,395 Views
16 Pages

2 August 2020

In this work, dewatered waste activated sludge (DWAS) was subjected to hydrothermal carbonization to obtain hydrochars that can be used as renewable solid fuels or activated carbon precursors. A central composite rotatable design was used to analyze...

(This article belongs to the Section Materials Chemistry)
  • Feature Paper
  • Article
  • Open Access
27 Citations
5,184 Views
14 Pages

Viscosified Solid Lipidic Nanoparticles Based on Naringenin and Linolenic Acid for the Release of Cyclosporine A on the Skin

  • Sonia Trombino,
  • Camilla Servidio,
  • Annarita Stella Laganà,
  • Filomena Conforti and ,
  • Mariangela Marrelli and
  • Roberta Cassano
  • + 1 author+ 0 author

2 August 2020

Psoriasis is one of the most common human skin disorders. Although its pathogenesis is complex and not completely know, the hyperactivation of the immune system seem to have a key role. In this regard, among the most effective systemic therapeutics u...

(This article belongs to the Section Macromolecular Chemistry)
  • Article
  • Open Access
61 Citations
11,195 Views
29 Pages

GC-MS Phytochemical Profiling, Pharmacological Properties, and In Silico Studies of Chukrasia velutina Leaves: A Novel Source for Bioactive Agents

  • Israt Jahan,
  • Marzia Rahman Tona,
  • Sanjida Sharmin,
  • Mohammed Aktar Sayeed and ,
  • Fatamatuz Zuhura Tania,
  • Arkajyoti Paul,
  • Md. Nazim Uddin Chy,
  • Ahmed Rakib,
  • Talha Bin Emran and
  • Jesus Simal-Gandara
  • + 5 authors+ 0 author

2 August 2020

Chukrasia velutina is a local medicinal plant commonly known as chikrassy in Bangladesh, India, China, and other South Asian countries. The leaves, bark, and seeds are vastly used as herbal medicine for fever and diarrhea, and its leaves essential oi...

(This article belongs to the Special Issue Modern Analytical Techniques in Metabolomics Analysis)
  • Review
  • Open Access
201 Citations
22,302 Views
25 Pages

2 August 2020

Wood is a renewable, versatile material with multiple applications and the largest terrestrial pool of sequestered carbon. However, it is susceptible to degradation, mainly caused by wood-decaying fungi. Since several traditional wood preservatives h...

(This article belongs to the Special Issue Natural Products and Their Semi-synthetic Derivatives against Bacteria, Fungi and Parasites)
  • Article
  • Open Access
41 Citations
7,689 Views
20 Pages

Dissolving Cellulose in 1,2,3-Triazolium- and Imidazolium-Based Ionic Liquids with Aromatic Anions

  • Martin Brehm,
  • Julian Radicke,
  • Martin Pulst,
  • Farzaneh Shaabani and ,
  • Daniel Sebastiani and
  • Jörg Kressler
  • + 1 author+ 0 author

2 August 2020

We present 1,2,3-triazolium- and imidazolium-based ionic liquids (ILs) with aromatic anions as a new class of cellulose solvents. The two anions in our study, benzoate and salicylate, possess a lower basicity when compared to acetate and therefore sh...

(This article belongs to the Special Issue Ionic Liquids, from Their Synthesis to Their Applications)
  • Feature Paper
  • Article
  • Open Access
34 Citations
7,406 Views
26 Pages

Spin Density Topology

  • Giovanna Bruno,
  • Giovanni Macetti,
  • Leonardo Lo Presti and
  • Carlo Gatti

2 August 2020

Despite its role in spin density functional theory and it being the basic observable for describing and understanding magnetic phenomena, few studies have appeared on the electron spin density subtleties thus far. A systematic full topological analys...

(This article belongs to the Special Issue Advances in the Theory of Chemical Bonding)
  • Article
  • Open Access
24 Citations
6,845 Views
16 Pages

New Series of Double-Modified Colchicine Derivatives: Synthesis, Cytotoxic Effect and Molecular Docking

  • Julia Krzywik,
  • Maral Aminpour,
  • Ewa Maj,
  • Witold Mozga and ,
  • Joanna Wietrzyk,
  • Jack A. Tuszyński and
  • Adam Huczyński
  • + 2 authors+ 0 author

2 August 2020

Colchicine is a well-known anticancer compound showing antimitotic effect on cells. Its high cytotoxic activity against different cancer cell lines has been demonstrated many times. In this paper we report the syntheses and spectroscopic analyses of...

(This article belongs to the Special Issue Anticancer Drug Discovery and Development)
  • Article
  • Open Access
9 Citations
4,528 Views
11 Pages

1 August 2020

Tetracycline (TET) has been widely used in the treatment of Streptococcus suis (S. suis) infection. However, it was found that the efficacy of many antibiotics in S. suis decreased significantly, especially tetracycline. In this study, GML-12 (a nove...

(This article belongs to the Special Issue 25th Anniversary of Molecules—Recent Advances in Medicinal Chemistry)
  • Review
  • Open Access
113 Citations
36,536 Views
16 Pages

Cranberry Polyphenols and Prevention against Urinary Tract Infections: Relevant Considerations

  • Dolores González de Llano,
  • M. Victoria Moreno-Arribas and
  • Begoña Bartolomé

1 August 2020

Cranberry (Vaccinium macrocarpon) is a distinctive source of polyphenols as flavonoids and phenolic acids that has been described to display beneficial effects against urinary tract infections (UTIs), the second most common type of infections worldwi...

(This article belongs to the Special Issue Flavonoids and Their Disease Prevention and Treatment Potential)
  • Article
  • Open Access
12 Citations
3,700 Views
11 Pages

Analysis of the Effect of the Biomass Torrefaction Process on Selected Parameters of Dust Explosivity

  • Marcin Bajcar,
  • Bogdan Saletnik,
  • Grzegorz Zaguła and
  • Czesław Puchalski

1 August 2020

This article presents the findings of a study investigating the explosion and combustion parameters of dust from the raw biomass of wheat straw and energy willow and from the products of biomass torrefaction generated at temperatures ranging from 220...

(This article belongs to the Special Issue Advances in Conversion of Biomass and Waste to Chemicals and Fuels)
  • Article
  • Open Access
3 Citations
4,137 Views
11 Pages

1 August 2020

The aggregation process of the Amyloidβ (Aβ) peptide is one of the central questions in Alzheimers’s research. Fluorescence-labeled single-molecule detection is a novel technique concerning the early stage investigation of Aβ agg...

(This article belongs to the Special Issue Amyloids in Neurodegenerative Diseases)
  • Article
  • Open Access
13 Citations
5,126 Views
21 Pages

The Spectrum of Design Solutions for Improving the Activity-Selectivity Product of Peptide Antibiotics against Multidrug-Resistant Bacteria and Prostate Cancer PC-3 Cells

  • Davor Juretić,
  • Anja Golemac,
  • Denise E. Strand,
  • Keshi Chung and ,
  • Nada Ilić,
  • Ivana Goić-Barišić and
  • François-Xavier Pellay
  • + 2 authors+ 0 author

1 August 2020

The link between the antimicrobial and anticancer activity of peptides has long been studied, and the number of peptides identified with both activities has recently increased considerably. In this work, we hypothesized that designed peptides with a...

(This article belongs to the Special Issue Novel Antibacterials: Antimicrobial Peptides, Peptidomimetics and Conjugates)
  • Review
  • Open Access
32 Citations
6,039 Views
13 Pages

Invasive Plants: Turning Enemies into Value

  • Patrícia Máximo,
  • Luísa M. Ferreira,
  • Paula S. Branco and
  • Ana Lourenço

1 August 2020

In this review, a brief description of the invasive phenomena associated with plants and its consequences to the ecosystem is presented. Five worldwide invasive plants that are a threat to Portugal were selected as an example, and a brief description...

(This article belongs to the Section Natural Products Chemistry)
  • Article
  • Open Access
30 Citations
5,880 Views
18 Pages

Flavonoids and Terpenoids with PTP-1B Inhibitory Properties from the Infusion of Salvia amarissima Ortega

  • Eric Salinas-Arellano,
  • Araceli Pérez-Vásquez,
  • Isabel Rivero-Cruz,
  • Rafael Torres-Colin and ,
  • Martín González-Andrade,
  • Manuel Rangel-Grimaldo and
  • Rachel Mata
  • + 2 authors+ 0 author

1 August 2020

An infusion prepared from the aerial parts of Salvia amarissima Ortega inhibited the enzyme protein tyrosine phosphatase 1B (PTP-1B) (IC50~88 and 33 μg/mL, respectively). Phytochemical analysis of the infusion yielded amarisolide (1), 5,6,4′...

(This article belongs to the Special Issue From Ethnobotany to Ecopharmacognosy: Chemical Characterization and Bioactivity Evaluation of Medicinal and Aromatic Plants)
  • Article
  • Open Access
49 Citations
6,206 Views
13 Pages

Identification of Polyphenols from Coniferous Shoots as Natural Antioxidants and Antimicrobial Compounds

  • Marcin Dziedzinski,
  • Joanna Kobus-Cisowska,
  • Daria Szymanowska,
  • Kinga Stuper-Szablewska and
  • Marlena Baranowska

1 August 2020

Currently, coniferous shoots are almost absent as a food ingredient despite their wide availability in many parts of the world. The aim of the study was to assess and compare the composition of selected plant metabolites, evaluate the antioxidant and...

(This article belongs to the Special Issue Plant Waste Management: Bioactive Compounds with Therapeutic Role in Disease Prevention)
  • Review
  • Open Access
56 Citations
11,568 Views
33 Pages

Bioactive Compounds and Metabolites from Grapes and Red Wine in Breast Cancer Chemoprevention and Therapy

  • Danielly C. Ferraz da Costa,
  • Luciana Pereira Rangel,
  • Julia Quarti,
  • Ronimara A. Santos and ,
  • Jerson L. Silva and
  • Eliane Fialho
  • + 1 author+ 0 author

1 August 2020

Phytochemicals and their metabolites are not considered essential nutrients in humans, although an increasing number of well-conducted studies are linking their higher intake with a lower incidence of non-communicable diseases, including cancer. This...

(This article belongs to the Special Issue Anticancer Properties of Natural and Derivative Products)
  • Article
  • Open Access
86 Citations
7,837 Views
21 Pages

Bioactive Compounds, Antioxidant Activity, and Antinutritional Content of Legumes: A Comparison between Four Phaseolus Species

  • Montserrat Alcázar-Valle,
  • Eugenia Lugo-Cervantes,
  • Luis Mojica,
  • Norma Morales-Hernández and ,
  • Heidy Reyes-Ramírez,
  • Jhony Navat Enríquez-Vara and
  • Soledad García-Morales
  • + 2 authors+ 0 author

1 August 2020

Beans (Phaseolus spp.) are one of the most important legumes for their nutritional value and health benefits in many world regions. In addition to Phaseolus vulgaris, there are four additional species that are cultivated in many regions of the world...

(This article belongs to the Special Issue Bioactive Phenolic and Polyphenolic Compounds)
  • Review
  • Open Access
53 Citations
11,857 Views
33 Pages

1 August 2020

In the field of gas separation and purification, membrane technologies compete with conventional purification processes on the basis of technical, economic and environmental factors. In this context, there is a growing interest in the development of...

(This article belongs to the Special Issue Lignocellulosic Materials)
  • Article
  • Open Access
83 Citations
7,034 Views
17 Pages

Fractionation of Biomolecules in Withania coagulans Extract for Bioreductive Nanoparticle Synthesis, Antifungal and Biofilm Activity

  • Murtaza Hasan,
  • Ayesha Zafar,
  • Irum Shahzadi,
  • Fan Luo and ,
  • Shahbaz Gul Hassan,
  • Tuba Tariq,
  • Sadaf Zehra,
  • Tauseef Munawar,
  • Faisal Iqbal and
  • Xugang Shu
  • + 5 authors+ 0 author

31 July 2020

Withania coagulans contains a complex mixture of various bioactive compounds. In order to reduce the complexity of the plant extract to purify its phytochemical biomolecules, a novel fractionation strategy using different solvent combination ratios w...

(This article belongs to the Special Issue Insecticide, Acaricide, Repellent and Antimicrobial Development)
  • Article
  • Open Access
14 Citations
5,425 Views
16 Pages

Cocaine Self-Administration and Abstinence Modulate NMDA Receptor Subunits and Active Zone Proteins in the Rat Nucleus Accumbens

  • Irena Smaga,
  • Karolina Wydra,
  • Małgorzata Frankowska,
  • Fabio Fumagalli and ,
  • Marek Sanak and
  • Małgorzata Filip
  • + 1 author+ 0 author

31 July 2020

Cocaine-induced plasticity in the glutamatergic transmission and its N-methyl-d-aspartate (NMDA) receptors are critically involved in the development of substance use disorder. The presynaptic active zone proteins control structural synaptic plastici...

  • Article
  • Open Access
39 Citations
6,192 Views
23 Pages

Chemo-Protective Potential of Cerium Oxide Nanoparticles against Fipronil-Induced Oxidative Stress, Apoptosis, Inflammation and Reproductive Dysfunction in Male White Albino Rats

  • Hamida Saleh,
  • Atef M. K. Nassar,
  • Ahmed E. Noreldin,
  • Dalia Samak and ,
  • Norhan Elshony,
  • Lamiaa Wasef,
  • Yaser H. A. Elewa,
  • Shaimaa M. A. Hassan,
  • Abdullah A. Saati and
  • Yasser S. El-Sayed
  • + 9 authors+ 4 authors

31 July 2020

Fipronil (FIP) is an insecticide commonly used in many fields, such as agriculture, veterinary medicine, and public health, and recently it has been proposed as a potential endocrine disrupter. The purpose of this study was to inspect the reproductiv...

(This article belongs to the Special Issue Nanochemistry: Good Beginnings for a Cross-Disciplinary Platform)
  • Feature Paper
  • Article
  • Open Access
36 Citations
5,535 Views
13 Pages

31 July 2020

Honey is a natural food widely consumed due to its high content in nutrients and bioactive substances. In order to prevent hive infections, xenobiotics such as pesticides and antibiotics are commonly used. Chloramphenicol (CAP) is a broad-spectrum an...

(This article belongs to the Special Issue New Analytical Strategy in Food Safety)
  • Review
  • Open Access
65 Citations
11,300 Views
37 Pages

Peptide-Based Nanoassemblies in Gene Therapy and Diagnosis: Paving the Way for Clinical Application

  • Shabnam Tarvirdipour,
  • Xinan Huang,
  • Voichita Mihali,
  • Cora-Ann Schoenenberger and
  • Cornelia G. Palivan

31 July 2020

Nanotechnology approaches play an important role in developing novel and efficient carriers for biomedical applications. Peptides are particularly appealing to generate such nanocarriers because they can be rationally designed to serve as building bl...

(This article belongs to the Special Issue Functional Peptide-Based Nanomaterials)
  • Review
  • Open Access
29 Citations
9,806 Views
18 Pages

31 July 2020

DNA, the fundamental genetic polymer of all living organisms on Earth, can be chemically modified to embrace novel functions that do not exist in nature. The key chemical and structural parameters for genetic information storage, heredity, and evolut...

(This article belongs to the Special Issue Advances in Nucleoside/Nucleotides and Nucleic Acid Chemistry: A Theme Issue in Honor of Prof. Dr. Piet Herdewijn)
  • Review
  • Open Access
124 Citations
19,939 Views
45 Pages

Plant Natural Products for the Control of Aedes aegypti: The Main Vector of Important Arboviruses

  • Maíra Rosato Silveiral Silvério,
  • Laila Salmen Espindola,
  • Norberto Peporine Lopes and
  • Paulo Cézar Vieira

31 July 2020

The mosquito species Aedes aegypti is one of the main vectors of arboviruses, including dengue, Zika and chikungunya. Considering the deficiency or absence of vaccines to prevent these diseases, vector control remains an important strategy. The use o...

(This article belongs to the Special Issue Feature Papers to Celebrate Molecules Reaches 20,000 Articles Milestone)
  • Article
  • Open Access
12 Citations
9,805 Views
12 Pages

31 July 2020

A non-empirical exchange functional based on an interpolation between two limits of electron density, slowly varying limit and asymptotic limit, is proposed. In the slowly varying limit, we follow the study by Kleinman from 1984 which considered the...

(This article belongs to the Special Issue 25th Anniversary of Molecules—Recent Advances in Computational and Theoretical Chemistry)
  • Article
  • Open Access
25 Citations
4,688 Views
14 Pages

Application of Nanoemulsions (W/O) of Extract of Opuntia oligacantha C.F. Först and Orange Oil in Gelatine Films

  • Salvador Omar Espino-Manzano,
  • Arely León-López,
  • Gabriel Aguirre-Álvarez,
  • Uriel González-Lemus and ,
  • Laurette Prince and
  • Rafael Germán Campos-Montiel
  • + 1 author+ 0 author

31 July 2020

Over the past decade, consumers have demanded natural, completely biodegradable active packaging serving as food containers. Bioactive plant compounds can be added to biopolymer-based films to improve their functionality, as they not only act as barr...

(This article belongs to the Special Issue Stabilization of Active Principles in Food Packaging Materials)
  • Article
  • Open Access
41 Citations
6,197 Views
26 Pages

A Novel Hybrid Model Based on a Feedforward Neural Network and One Step Secant Algorithm for Prediction of Load-Bearing Capacity of Rectangular Concrete-Filled Steel Tube Columns

  • Quang Hung Nguyen,
  • Hai-Bang Ly,
  • Van Quan Tran,
  • Thuy-Anh Nguyen and ,
  • Viet-Hung Phan,
  • Tien-Thinh Le and
  • Binh Thai Pham
  • + 2 authors+ 0 author

31 July 2020

In this study, a novel hybrid surrogate machine learning model based on a feedforward neural network (FNN) and one step secant algorithm (OSS) was developed to predict the load-bearing capacity of concrete-filled steel tube columns (CFST), whereas th...

(This article belongs to the Special Issue Metallic and Composite Materials and Structures)
  • Article
  • Open Access
10 Citations
7,265 Views
22 Pages

31 July 2020

Focal adhesion kinase (FAK) is a tyrosine kinase that is overexpressed and activated in several advanced-stage solid cancers. In cancer cells, FAK promotes the progression and metastasis of tumours. In this study, we used structure-based virtual scre...

(This article belongs to the Special Issue 25th Anniversary of Molecules—Recent Advances in Medicinal Chemistry)
  • Review
  • Open Access
46 Citations
7,304 Views
23 Pages

Gold Nanoparticles for Vectorization of Nucleic Acids for Cancer Therapeutics

  • Daniela Ferreira,
  • David Fontinha,
  • Catarina Martins,
  • David Pires and ,
  • Alexandra R. Fernandes and
  • Pedro V. Baptista
  • + 1 author+ 0 author

31 July 2020

Cancer remains a complex medical challenge and one of the leading causes of death worldwide. Nanomedicines have been proposed as innovative platforms to tackle these complex diseases, where the combination of several treatment strategies might enhanc...

(This article belongs to the Special Issue Nanoparticles and Their Biological and Biomedical Applications)
  • Review
  • Open Access
24 Citations
7,244 Views
37 Pages

31 July 2020

Water radical cations, (H2O)n+•, are of great research interest in both fundamental and applied sciences. Fundamental studies of water radical reactions are important to better understand the mechanisms of natural processes, such as proton trans...

(This article belongs to the Section Physical Chemistry)

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