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Molecules, Volume 25, Issue 16

August-2 2020 - 206 articles

Cover Story: Corydalis solida Clairv. and Pseudofumaria lutea Borkh. (synonym Corydalis lutea DC.) from the Papaveraceae subfamily Fumarioideae, are two representative species of their genera. The taxonomic relationships within this subfamily are complex and we need more data on their phytochemical composition that can contribute to understanding their chemophenetic and phytomedicinal importance. The LC-MS analysis revealed striking differences in alkaloid and other metabolites profiles between both species, supporting their taxonomic separation into two genera. Moreover, the high content of coptisine and quercetin in P.lutea and its efficacy against pathogenic bacteria and fungi make this species a promising material with significant potential in pharmacotherapy. View this paper.
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Articles (206)

  • Article
  • Open Access
43 Citations
6,220 Views
19 Pages

18 August 2020

Adsorptive removal of rose bengal (RB) from contaminated water samples was approached using pineapple leaves (PAL). Three adsorbents were utilized for that purpose; raw pineapple leaves (RPAL) and the thermally activated bio-waste leaves at 250 and 5...

  • Feature Paper
  • Review
  • Open Access
24 Citations
7,027 Views
23 Pages

IDH1 Targeting as a New Potential Option for Intrahepatic Cholangiocarcinoma Treatment—Current State and Future Perspectives

  • Fabiana Crispo,
  • Michele Pietrafesa,
  • Valentina Condelli,
  • Francesca Maddalena,
  • Giuseppina Bruno,
  • Annamaria Piscazzi,
  • Alessandro Sgambato,
  • Franca Esposito and
  • Matteo Landriscina

18 August 2020

Cholangiocarcinoma is a primary malignancy of the biliary tract characterized by late and unspecific symptoms, unfavorable prognosis, and few treatment options. The advent of next-generation sequencing has revealed potential targetable or actionable...

  • Article
  • Open Access
24 Citations
4,090 Views
20 Pages

Inequality in the Frequency of the Open States Occurrence Depends on Single 2H/1H Replacement in DNA

  • Alexander Basov,
  • Mikhail Drobotenko,
  • Alexandr Svidlov,
  • Eugeny Gerasimenko,
  • Vadim Malyshko,
  • Anna Elkina,
  • Mikhail Baryshev and
  • Stepan Dzhimak

18 August 2020

In the present study, the effect of 2H/1H isotopic exchange in hydrogen bonds between nitrogenous base pairs on occurrence and open states zones dynamics is investigated. These processes are studied using mathematical modeling, taking into account th...

  • Article
  • Open Access
10 Citations
4,159 Views
17 Pages

Cytotoxic and Anti-Plasmodial Activities of Stephania dielsiana Y.C. Wu Extracts and the Isolated Compounds

  • James Knockleby,
  • Bruno Pradines,
  • Mathieu Gendrot,
  • Joel Mosnier,
  • Thanh Tam Nguyen,
  • Thi Thuy Trinh,
  • Hoyun Lee and
  • Phuong Mai Le

18 August 2020

Natural products remain a viable source of novel therapeutics, and as detection and extraction techniques improve, we can identify more molecules from a broader set of plant tissues. The aim of this study was an investigation of the cytotoxic and ant...

  • Article
  • Open Access
19 Citations
4,841 Views
18 Pages

Radiochemical Synthesis and Evaluation of Novel Radioconjugates of Neurokinin 1 Receptor Antagonist Aprepitant Dedicated for NK1R-Positive Tumors

  • Paweł K. Halik,
  • Piotr F. J. Lipiński,
  • Joanna Matalińska,
  • Przemysław Koźmiński,
  • Aleksandra Misicka and
  • Ewa Gniazdowska

18 August 2020

Aprepitant, a lipophilic and small molecular representative of neurokinin 1 receptor antagonists, is known for its anti-proliferative activity on numerous cancer cell lines that are sensitive to Substance P mitogen action. In the presented research,...

  • Article
  • Open Access
15 Citations
4,878 Views
17 Pages

Chemical Characterisation and Antihypertensive Effects of Locular Gel and Serum of Lycopersicum esculentum L. var. “Camone” Tomato in Spontaneously Hypertensive Rats

  • Paola Marcolongo,
  • Alessandra Gamberucci,
  • Gabriella Tamasi,
  • Alessio Pardini,
  • Claudia Bonechi,
  • Claudio Rossi,
  • Roberta Giunti,
  • Virginia Barone,
  • Annalisa Borghini and
  • Paolo Fiorenzani
  • + 3 authors

18 August 2020

Blood pressure control in hypertensive subjects calls for changes in lifestyle, especially diet. Tomato is widely consumed and rich in healthy components (i.e., carotenoids, vitamins and polyphenols). The aim of this study was to evaluate the chemica...

  • Feature Paper
  • Review
  • Open Access
15 Citations
4,422 Views
24 Pages

Hydrogen-Mediated Noncovalent Interactions in Solids: What Can NMR Crystallography Tell About?

  • Ioana Georgeta Grosu,
  • Xenia Filip,
  • Maria O. Miclăuș and
  • Claudiu Filip

18 August 2020

Hydrogen atoms play a crucial role in the aggregation of organic (bio)molecules through diverse number of noncovalent interactions that they mediate, such as electrostatic in proton transfer systems, hydrogen bonding, and CH–π interactions,...

  • Article
  • Open Access
9 Citations
3,871 Views
17 Pages

18 August 2020

In this work, a membrane-based process for the purification and concentration of antioxidant compounds from aqueous Goji (Lycium barbarum L.) berry extracts was investigated. The aqueous extract was previously clarified with hollow fiber ultrafiltrat...

  • Article
  • Open Access
8 Citations
3,888 Views
14 Pages

Serum Metabolic Profiling Reveals Potential Anti-Inflammatory Effects of the Intake of Black Ginseng Extracts in Beagle Dogs

  • Ye Jin Kim,
  • Dae Young Lee,
  • Ho-Eun Park,
  • Dahye Yoon,
  • Bumkyu Lee,
  • Jae Geun Kim,
  • Kyung-Hoan Im,
  • Young-Seob Lee,
  • Wan-Kyu Lee and
  • Jae Kwang Kim

18 August 2020

Black ginseng (BG) has better health benefits than white ginseng. The intake of BG changes the levels of metabolites, such as amino acids, fatty acids, and other metabolites. However, there is no research on the effect of BG extract intake on the met...

  • Feature Paper
  • Review
  • Open Access
122 Citations
8,219 Views
45 Pages

18 August 2020

Polymeric nanocarriers (PNs) have demonstrated to be a promising alternative to treat intracellular infections. They have outstanding performance in delivering antimicrobials intracellularly to reach an adequate dose level and improve their therapeut...

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Molecules - ISSN 1420-3049