E-Mail Alert

Add your e-mail address to receive forthcoming issues of this journal:

Journal Browser

Journal Browser

Special Issue "Modern Analytical Techniques in Metabolomics Analysis"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Analytical Chemistry".

Deadline for manuscript submissions: 31 October 2019

Special Issue Editor

Guest Editor
Prof. Dr. Jesus Simal-Gandara

Food Science Lab, Department of Analytical and Food Chemistry, Faculty of Food Science and Technology, University of Vigo-Ourense Campus, E-32004 Ourense, Spain
E-Mail
Phone: +34-988-387060 (or +34-988-387260)
Fax: +34-988-387001
Interests: food authenticity; food chemistry; Persistent Organic Pollutants (POPs) in the food chain; sensorial analysis; functional ingredients; functional foods

Special Issue Information

Dear Colleagues,

Metabolomics is the complete evaluation of endogenous metabolites and aims to systematically identify and quantify metabolites from a biological sample. Small molecule metabolites play an important role in biological systems and are interesting candidates for understanding the phenotypes of an organism. The metabolites represent a heterogeneous group of low molecular weight structures, including lipids, amino acids, peptides, nucleic acids, organic acids, vitamins, thiols and carbohydrates, making the overall analysis difficult. The recent rapid development of a range of analysis platforms, including GC, UPLC, CE, etc., coupled with MS and NMR spectroscopy, could allow the separation, detection, characterization and quantification of these metabolites and associated metabolic pathways. The combined use of modern instrumental analytical approaches is useful for increasing the coverage of the detected metabolites that cannot be achieved with single analytical techniques. The continuous development of these analytical platforms will accelerate the widespread use and integration of metabolomics in systems biology. This section will highlight the role of integrated tools in metabolomics research.

Prof. Dr. Jesus Simal-Gandara
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolomics
  • untargeted methods
  • targeted methods
  • analytical chemistry
  • biomarkers
  • profiling
  • fingerprinting

Published Papers (1 paper)

View options order results:
result details:
Displaying articles 1-1
Export citation of selected articles as:

Research

Open AccessArticle
Effects of Silymarin on the In Vivo Pharmacokinetics of Simvastatin and Its Active Metabolite in Rats
Molecules 2019, 24(9), 1666; https://doi.org/10.3390/molecules24091666
Received: 12 April 2019 / Revised: 23 April 2019 / Accepted: 25 April 2019 / Published: 28 April 2019
PDF Full-text (1265 KB) | HTML Full-text | XML Full-text
Abstract
Herein, the effect of silymarin pretreatment on the pharmacokinetics of simvastatin in rats was evaluated. To ensure the accuracy of the results, a rapid and sensitive UPLC–MS/MS method was established for simultaneous quantification of simvastatin (SV) and its active metabolite simvastatin acid (SVA). [...] Read more.
Herein, the effect of silymarin pretreatment on the pharmacokinetics of simvastatin in rats was evaluated. To ensure the accuracy of the results, a rapid and sensitive UPLC–MS/MS method was established for simultaneous quantification of simvastatin (SV) and its active metabolite simvastatin acid (SVA). This method was applied for studying the pharmacokinetic interactions in rats after oral co-administration of silymarin (45 mg/kg) and different concentrations of SV. The major pharmacokinetic parameters, including Cmax, tmax, t1/2, mean residence time (MRT), elimination rate constant (λz) and area under the concentration-time curve (AUC0–12h), were calculated using the non-compartmental model. The results showed that the co-administration of silymarin and SV significantly increased the Cmax and AUC0–12h of SVA compared with SV alone, while there was no significant difference with regards to Tmax and t1/2. However, SV pharmacokinetic parameters were not significantly affected by silymarin pretreatment. Therefore, these changes indicated that drug-drug interactions may occur after co-administration of silymarin and SV. Full article
(This article belongs to the Special Issue Modern Analytical Techniques in Metabolomics Analysis)
Figures

Figure 1

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top