Table of Contents
Molecules, Volume 25, Issue 10 (May-2 2020) – 196 articles
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Cover Story (view full-size image) In a process called priming, coronavirus strains require cleavage of their spike glycoprotein at [...] Read more. In a process called priming, coronavirus strains require cleavage of their spike glycoprotein at various sites by human host proteases to initiate the invasion of host cells. Low pathogenic coronavirus strains depend on the trypsin-like protease TMPRSS2 for priming. However, in the highly pathogenic SARS-CoV2, causative of COVID-19, the priming site is also recognized by the serin protease furin. Unlike TMPRSS2, furin is ubiquitously expressed in several organs, which may contribute to the increased pathogenicity of SARS-CoV2. Hence, we propose the development of either pan-serine protease inhibitors or inhibitor cocktails to target SARS-CoV2 and potentially to ward off future pandemics that could develop because of additional mutations in the S-protein priming sequences in coronaviruses. View this paper.