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Molecules, Volume 25, Issue 10

May-2 2020 - 196 articles

Cover Story: In a process called priming, coronavirus strains require cleavage of their spike glycoprotein at various sites by human host proteases to initiate the invasion of host cells. Low pathogenic coronavirus strains depend on the trypsin-like protease TMPRSS2 for priming. However, in the highly pathogenic SARS-CoV2, causative of COVID-19, the priming site is also recognized by the serin protease furin. Unlike TMPRSS2, furin is ubiquitously expressed in several organs, which may contribute to the increased pathogenicity of SARS-CoV2. Hence, we propose the development of either pan-serine protease inhibitors or inhibitor cocktails to target SARS-CoV2 and potentially to ward off future pandemics that could develop because of additional mutations in the S-protein priming sequences in coronaviruses. View this paper.
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Articles (196)

  • Review
  • Open Access
28 Citations
6,224 Views
26 Pages

Crystal Chemistry of High-Temperature Borates

  • Nikolay I. Leonyuk,
  • Victor V. Maltsev and
  • Elena A. Volkova

In recent years borate-based crystals has attracted substantial interest among the research community. The overall importance of this family of materials is reflected in miscellaneous articles and several reviews that have been published over the yea...

  • Article
  • Open Access
17 Citations
5,060 Views
13 Pages

The Synergistic Anti-Cancer Effects of NVP-BEZ235 and Regorafenib in Hepatocellular Carcinoma

  • Cheng-Chan Yu,
  • Sung-Ying Huang,
  • Shu-Fang Chang,
  • Kuan-Fu Liao and
  • Sheng-Chun Chiu

Hepatocellular carcinoma (HCC) is the most common type of liver cancer worldwide. Regorafenib is a multi-kinase inhibitor and the second-line treatment for HCC. Since the PI3K/Akt/mTOR signaling pathway is dysregulated in HCC, we evaluated the therap...

  • Article
  • Open Access
21 Citations
3,835 Views
13 Pages

Evaluation of Organosolv Lignin as an Oxidation Inhibitor in Bitumen

  • Yi Zhang,
  • Xueyan Liu,
  • Panos Apostolidis,
  • Ruxin Jing,
  • Sandra Erkens,
  • Natascha Poeran and
  • Athanasios Skarpas

Organosolv lignin, a natural polymer, has been used in this study as an oxidation inhibitor in bitumen. Particularly, the effect of oxidative aging on the chemical compositional changes and on the rheology of bituminous binders with organosolv lignin...

  • Review
  • Open Access
6 Citations
5,309 Views
50 Pages

Results of a detailed structural characterization of nominally pure and doped single crystals of scheelite, eulytin, and perovskite families obtained by melt methods were considered and analyzed. The influence of growth and post-growth annealing cond...

  • Article
  • Open Access
14 Citations
3,967 Views
17 Pages

A new topological design of fluorescent probes for sensing copper ion is disclosed. The calix[4]arene-oxacyclophane (Calix-OCP) receptor, either wired-in-series in arylene-alt-ethynylene conjugated polymers or standing alone as a sole molecular probe...

  • Article
  • Open Access
21 Citations
8,205 Views
11 Pages

Antiobesity Effects of Gentiana lutea Extract on 3T3-L1 Preadipocytes and a High-Fat Diet-Induced Mouse Model

  • Eunkuk Park,
  • Chang Gun Lee,
  • Junho Kim,
  • Subin Yeo,
  • Ji Ae Kim,
  • Chun Whan Choi and
  • Seon-Yong Jeong

Obesity is one of the most common metabolic diseases resulting in metabolic syndrome. In this study, we investigated the antiobesity effect of Gentiana lutea L. (GL) extract on 3T3-L1 preadipocytes and a high-fat-diet (HFD)-induced mouse model. For t...

  • Article
  • Open Access
13 Citations
5,572 Views
11 Pages

Streptavidin-Hosted Organocatalytic Aldol Addition

  • Nicolò Santi,
  • Louis C. Morrill and
  • Louis Y. P. Luk

In this report, the streptavidin-biotin technology was applied to enable organocatalytic aldol addition. By attaching pyrrolidine to the valeric motif of biotin and introducing it to streptavidin (Sav), a protein-based organocatalytic system was crea...

  • Article
  • Open Access
31 Citations
6,963 Views
12 Pages

A Direct Silanization Protocol for Dialdehyde Cellulose

  • Arianna Lucia,
  • Markus Bacher,
  • Hendrikus W. G. van Herwijnen and
  • Thomas Rosenau

Cellulose derivatives have many potential applications in the field of biomaterials and composites, in addition to several ways of modification leading to them. Silanization in aqueous media is one of the most promising routes to create multipurpose...

  • Article
  • Open Access
12 Citations
3,785 Views
23 Pages

Dual miRNases for Triple Incision of miRNA Target: Design Concept and Catalytic Performance

  • Olga Patutina,
  • Daria Chiglintseva,
  • Elena Bichenkova,
  • Svetlana Gaponova,
  • Nadezhda Mironova,
  • Valentin Vlassov and
  • Marina Zenkova

Irreversible destruction of disease-associated regulatory RNA sequences offers exciting opportunities for safe and powerful therapeutic interventions against human pathophysiology. In 2017, for the first time we introduced miRNAses–miRNA-target...

  • Review
  • Open Access
30 Citations
4,116 Views
15 Pages

Innovations in Extractive Phases for In-Tube Solid-Phase Microextraction Coupled to Miniaturized Liquid Chromatography: A Critical Review

  • Henry Daniel Ponce-Rodríguez,
  • Jorge Verdú-Andrés,
  • Rosa Herráez-Hernández and
  • Pilar Campíns-Falcó

Over the past years, a great effort has been devoted to the development of new sorbents that can be used to pack or to coat extractive capillaries for in-tube solid-phase microextraction (IT-SPME). Many of those efforts have been focused on the prepa...

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Molecules - ISSN 1420-3049