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The Positive Side of the Alzheimer’s Disease Amyloid Cross-Interactions: The Case of the Aβ 1-42 Peptide with Tau, TTR, CysC, and ApoA1

1
Department of Pharmacy, University of Pisa, via Bonanno 6, 56126 Pisa, Italy
2
CNRS, BioCIS, Université Paris-Saclay, rue Jean-Baptiste Clément 5, 92290 Châtenay-Malabry, France
3
Département Médicaments et Technologies pour la Santé (DMTS), CEA, INRAE, Université Paris Saclay, SIMoS, 91191 Gif-sur-Yvette, France
*
Authors to whom correspondence should be addressed.
Academic Editor: Veronica Dodero
Molecules 2020, 25(10), 2439; https://doi.org/10.3390/molecules25102439
Received: 1 May 2020 / Revised: 18 May 2020 / Accepted: 22 May 2020 / Published: 23 May 2020
Alzheimer’s disease (AD) represents a progressive amyloidogenic disorder whose advancement is widely recognized to be connected to amyloid-β peptides and Tau aggregation. However, several other processes likely contribute to the development of AD and some of them might be related to protein-protein interactions. Amyloid aggregates usually contain not only single type of amyloid protein, but also other type of proteins and this phenomenon can be rationally explained by the process of protein cross-seeding and co-assembly. Amyloid cross-interaction is ubiquitous in amyloid fibril formation and so a better knowledge of the amyloid interactome could help to further understand the mechanisms of amyloid related diseases. In this review, we discuss about the cross-interactions of amyloid-β peptides, and in particular Aβ1-42, with other amyloids, which have been presented either as integrated part of Aβ neurotoxicity process (such as Tau) or conversely with a preventive role in AD pathogenesis by directly binding to Aβ (such as transthyretin, cystatin C and apolipoprotein A1). Particularly, we will focus on all the possible therapeutic strategies aiming to rescue the Aβ toxicity by taking inspiration from these protein-protein interactions. View Full-Text
Keywords: Alzheimer’s disease; cross-interaction; amyloidosis; TTR; CysC; ApoA1; Tau; Aβ 1-42; peptidomimetic inhibitors; foldamers Alzheimer’s disease; cross-interaction; amyloidosis; TTR; CysC; ApoA1; Tau; Aβ 1-42; peptidomimetic inhibitors; foldamers
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MDPI and ACS Style

Ciccone, L.; Shi, C.; di Lorenzo, D.; Van Baelen, A.-C.; Tonali, N. The Positive Side of the Alzheimer’s Disease Amyloid Cross-Interactions: The Case of the Aβ 1-42 Peptide with Tau, TTR, CysC, and ApoA1. Molecules 2020, 25, 2439.

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