Next Article in Journal
Discovery of a Natural Product That Binds to the Mycobacterium tuberculosis Protein Rv1466 Using Native Mass Spectrometry
Previous Article in Journal
NMR-Based Chemical Profiling, Isolation and Evaluation of the Cytotoxic Potential of the Diterpenoid Siderol from Cultivated Sideritis euboea Heldr.
Previous Article in Special Issue
Rationally Designed Ruthenium Complexes for Breast Cancer Therapy
Open AccessArticle

Anticancer Ruthenium Complexes with HDAC Isoform Selectivity

1
Department of Chemistry, Durham University, Lower Mountjoy, South Road, Durham DH1 3LE, UK
2
Department of Biosciences, Durham University, Stockton Road, Durham DH1 3LE, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Kogularamanan Suntharalingam
Molecules 2020, 25(10), 2383; https://doi.org/10.3390/molecules25102383
Received: 20 April 2020 / Revised: 13 May 2020 / Accepted: 16 May 2020 / Published: 21 May 2020
(This article belongs to the Special Issue Metal Anticancer Complexes)
The histone deacetylase (HDAC) enzymes have emerged as an important class of molecular targets in cancer therapy, with five inhibitors in clinical use. Recently, it has been shown that a lack of selectivity between the 11 Zn-dependent HDAC isoforms may lead to unwanted side-effects. In this paper, we show that piano stool Ru complexes can act as HDAC inhibitors, and variation in the capping arene leads to differences in HDAC isoform selectivity. View Full-Text
Keywords: histone deacetylase inhibitors; ruthenium in medicine; selective enzyme inhibition histone deacetylase inhibitors; ruthenium in medicine; selective enzyme inhibition
Show Figures

Graphical abstract

MDPI and ACS Style

Cross, J.M.; Blower, T.R.; Kingdon, A.D.H.; Pal, R.; Picton, D.M.; Walton, J.W. Anticancer Ruthenium Complexes with HDAC Isoform Selectivity. Molecules 2020, 25, 2383.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop