The ethanol extract of
the whole plants of
Viburnum mongolicum afforded six new nor-dammarane triterpenoids: 3
β,12
β-dihydroxy-25,26,27-trinordammara-22-en -24,20-olide (
1), 3
β,12
β-dihydroxy-24
α-methoxy-25,26,27-trinordammara-20,24-epoxy (
2), 3
β-
O-acetyl-12
β-hydroxy-23,24,25,26,27-hexanordammarane-20-one (
3
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The ethanol extract of
the whole plants of
Viburnum mongolicum afforded six new nor-dammarane triterpenoids: 3
β,12
β-dihydroxy-25,26,27-trinordammara-22-en -24,20-olide (
1), 3
β,12
β-dihydroxy-24
α-methoxy-25,26,27-trinordammara-20,24-epoxy (
2), 3
β-
O-acetyl-12
β-hydroxy-23,24,25,26,27-hexanordammarane-20-one (
3), 12
β-
O- acetyl-15
α-hydroxy-17
β-methoxy-3-oxo-20,21,22-23,24,25,26,27-octanordammanrane (
4), 12
β-
O-acetyl-15
α,17
β-dihydroxy-3-oxo-20,21,22-23,24,25,26,27-octanordammanrane (
5), and 12
β,15
α-dihydroxy-3-oxo-17-en-20,21,22-23,24,25,26,27-octanordammanrane (
6), together with two known nor-dammarane triterpenoids, 12
β-hydroxy-3-oxo-24
α-methoxy- 25,26,27-trinordammara-20,24-epoxy (
7) and 3
β,12
β-dihydroxy-23,24,25,26,27- hexanordammarane-20-one (
8). The structures of the isolated compounds were established based on 1D and 2D (
1H-
1H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated compounds were tested
in vitro for cytotoxic potential against seven tumor cell lines and radical scavenging activities. Compounds
4–
6 exhibited significant cytotoxic activities against all tested tumor cell lines and radical scavenging activities against ABTS
·+ radicals comparable with the standard drug Trolox.
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