Next Article in Journal
Synthesis of Thiophene and NO-Curcuminoids for Antiinflammatory and Anti-Cancer Activities
Previous Article in Journal
Crystal Structure, Antibacterial and Cytotoxic Activities of a New Complex of Bismuth(III) with Sulfapyridine
Article Menu

Article Versions

Export Article

Open AccessArticle
Molecules 2013, 18(2), 1477-1482; https://doi.org/10.3390/molecules18021477

Two New Derivatives of 2, 5-Dihydroxyphenylacetic Acid from the Kernel of Entada phaseoloides

1
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
2
Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study (No. BZ0150), Institute of Material Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
*
Authors to whom correspondence should be addressed.
Received: 14 January 2013 / Revised: 18 January 2013 / Accepted: 18 January 2013 / Published: 25 January 2013
PDF [206 KB, uploaded 18 June 2014]   |  

Abstract

Two new aromatic compounds, butyl 2,5-dihydroxyphenylacetate (1) and butyl 2-O-β-D-glucopyranosyloxy-5-dihydroxyphenylacetate (2), together with three known ones, methyl 2,5-dihydroxyphenylacetate (3), ethyl 2,5-dihydroxyphenylacetate (4) and 2-O-β-D-glucopyranosyloxy-5-hydroxyphenylacetic acid (5), were isolated from the EtOH extract of the kernel of Entada phaseoloides. The structures of the new compounds were elucidated by MS and NMR experiments. Compounds 1, 3 and 4 displayed potent inhibitory activities against HIV-1 replication, with EC50 values of 9.80 μM, 11.70 μM and 9.93 μM, respectively.
Keywords: Entada phaseoloides; Leguminosae; 2,5-dihydroxyphenylacetic acid; HIV-1 Entada phaseoloides; Leguminosae; 2,5-dihydroxyphenylacetic acid; HIV-1
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Chen, L.; Zhang, Y.; Ding, G.; Ba, M.; Guo, Y.; Zou, Z. Two New Derivatives of 2, 5-Dihydroxyphenylacetic Acid from the Kernel of Entada phaseoloides. Molecules 2013, 18, 1477-1482.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top