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Antioxidant Capacity of Two Novel Bioactive Fe(III)-Cyclophane Complexes

Departamento de Investigación en Polímeros y Materiales (DIPM), Universidad de Sonora, Calle Rosales y Blvd, Luis Encinas s/n, Col. Centro, PO Box 130. Hermosillo Sonora 83000, Mexico
Centro de Investigación en Alimentación y Desarrollo (CIAD), A.C. Carretera a Ejido La Victoria Km 0.6, PO Box 1735, Hermosillo Sonora 83304, Mexico
Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México (IBT-UNAM) Av. Universidad #2001, Col. Chamilpa, Cuernavaca, Morelos 62250, Mexico
Authors to whom correspondence should be addressed.
Molecules 2013, 18(2), 1762-1774;
Received: 13 November 2012 / Revised: 6 January 2013 / Accepted: 7 January 2013 / Published: 29 January 2013
The cyclophanes 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10, 24,27,30,33-octaaza-17,40-dioxa[]paracyclophane (PO) and 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10,24,27,30,33-octaaza[]paracyclophane (PC) were coordinated with iron to form cationic binuclear Fe(III) Fe2PO and Fe2PC complexes, respectively. Their antioxidant capacity, superoxide dismutase and peroxidase mimetic activity, as well as their toxicity toward peripheral blood mononuclear cells (PBMCs) were evaluated. Both Fe2PO and Fe2PC are interesting biomimetics with antioxidant capacity similar to that of ascorbic acid that prevent mortality in cultured PBMCs, with the potential to have bioactive and protective functions in disease animal models. View Full-Text
Keywords: cyclophane; macrocycle; iron; biomimetic; antioxidant cyclophane; macrocycle; iron; biomimetic; antioxidant
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Salazar-Medina, A.J.; Sugich-Miranda, R.; Teran-Cabanillas, E.; Hernández, J.; González-Aguilar, G.A.; Rudiño-Piñera, E.; Sotelo-Mundo, R.R.; Velázquez-Contreras, E.F. Antioxidant Capacity of Two Novel Bioactive Fe(III)-Cyclophane Complexes. Molecules 2013, 18, 1762-1774.

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