Molecules 2013, 18(2), 1973-1984; https://doi.org/10.3390/molecules18021973
Synthesis and Characterization of Novel Unsymmetrical and Symmetrical 3-Halo- or 3-Methoxy-substituted 2-Dibenzoylamino-1,4-naphthoquinone Derivatives
1
Department of Chemistry, Howard University, Washington, DC 20059, USA
2
Department of Natural Sciences, Bowie State University, Bowie, MD 20715, USA
*
Author to whom correspondence should be addressed.
Received: 31 December 2012 / Revised: 30 January 2013 / Accepted: 30 January 2013 / Published: 4 February 2013
(This article belongs to the Section Organic Chemistry)
Abstract
Symmetrical and unsymmetrical 3-halo- or 3-methoxy- substituted 2-dibenzoylamino- 1,4-naphthoquinone analogs were synthesized with an average yield of 45% via sodium hydride promoted bis-acylation of 2-amino-3-chloro-1,4-naphthoquinone, 2-amino-3-bromo-1,4-naphthoquinone and 2-amino-3-methoxy-1,4-naphthoquinone.Keywords:
1,4-naphthoquinone; imide synthesis; sodium hydride-promoted bis-acylation; unsymmetrical imide
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Brandy, Y.; Brandy, N.; Akinboye, E.; Lewis, M.; Mouamba, C.; Mack, S.; Butcher, R.J.; Anderson, A.J.; Bakare, O. Synthesis and Characterization of Novel Unsymmetrical and Symmetrical 3-Halo- or 3-Methoxy-substituted 2-Dibenzoylamino-1,4-naphthoquinone Derivatives. Molecules 2013, 18, 1973-1984.
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