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Original TDAE Strategy Using Propargylic Chloride: Rapid Access to 1,4-Diarylbut-3-ynol Derivatives

Laboratoire de Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Institut de Chimie Radicalaire ICR, UMR 7273, Aix-Marseille Univ, CNRS, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
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Molecules 2013, 18(2), 1540-1548; https://doi.org/10.3390/molecules18021540
Received: 12 November 2012 / Revised: 16 January 2013 / Accepted: 22 January 2013 / Published: 25 January 2013
(This article belongs to the Section Organic Chemistry)
We report herein the first synthesis of propargylic alcohols using an organic reducing agent. Diarylbutynol derivatives are formed in moderate to good yields under mild conditions from the reaction of 1-(3-chloroprop-1-ynyl)-4-nitrobenzene with various aromatic aldehydes using tetrakis(dimethylamino)ethylene (TDAE) as reductant. View Full-Text
Keywords: TDAE; propargylic alcohol; organic reducing agent; aromatic aldehyde TDAE; propargylic alcohol; organic reducing agent; aromatic aldehyde
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Roche, M.; Terme, T.; Vanelle, P. Original TDAE Strategy Using Propargylic Chloride: Rapid Access to 1,4-Diarylbut-3-ynol Derivatives. Molecules 2013, 18, 1540-1548.

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