Special Issue "Diels-Alder Reaction"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (31 December 2012).
Interests: intramolecular cycloadditions; microwave heating in organic synthesis; public perception of natural science
The Diels-Alder reaction, discovered in 1928, is widely recognized as one of the cornerstone synthetic organic reactions of the 20th century. In fact, it is one of the most commonly employed reactions for the synthesis of natural products, as well as for the rapid construction of cyclic and polycyclic compounds. The intramolecular extension of the Diels-Alder, first reported by Kurt Alder in 1952, led the way to a significant number of elegant synthetic achievements. Further historical developments (e.g., Lewis acid catalysis, frontier orbital theory, introduction of heteroatoms, comprehension of stereoelectronic features, solvent and temperature effects, the use of high pressure or microwave heating conditions, etc.) involving this Nobel-prize winning reaction have made the Diels-Alder reaction an efficient, reliable and powerful tool in the hands of synthetic chemists everywhere.
Molecules Special Issue on Diels-Alder chemistry will provide a timely venue for presenting key developments and important facets of this milestone reaction. I strongly encourage authors to submit papers for this Special Issue, and am hopeful that the topics published will assist in promoting novel applications of this exceptional process for the synthesis of organic molecules of interest and importance.
Prof. Raymond J. Giguere,
- Diels-Alder Reaction
- Hetero Diels-Alder
- [4 + 2]