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Sinapyl Alcohol Derivatives from the Lipo-soluble Part of Dichrocephala benthamii C. B. Clarke

1
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
2
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
3
Tianjin Key Laboratory for Biomarkers of Occupational and Environmental Hazard, Department of Pharmacognosy, Logistics University of Chinese People's Armed Police Forces, Tianjin 300162, China
*
Author to whom correspondence should be addressed.
Molecules 2013, 18(2), 1720-1727; https://doi.org/10.3390/molecules18021720
Received: 19 December 2012 / Revised: 18 January 2013 / Accepted: 18 January 2013 / Published: 29 January 2013
Four new sinapyl alcohol derivatives dichrocephols A–D (compounds 14) were isolated from the lipo-soluble part of the whole herb of Dichrocephala benthamii C. B. Clarke, together with the known compound syringenin isovalerate (5). Their structures were elucidated on the basis of spectroscopic analysis. Their absolute configurations were established by the method of alkaline hydrohysis. Compounds 13 showed moderate cytotoxity against HeLa cells, with IC50 values of 14.8 μM, 51.6 μM and 81.6 μM, respectively. This is the first time that sinapyl alcohol derivatives were isolated from the genus Dichrocephala. View Full-Text
Keywords: Dichrocephala benthamii C. B. Clarke; Asteraceae; sinapyl alcohol derivatives; absolute configuration determination; cytotoxicity Dichrocephala benthamii C. B. Clarke; Asteraceae; sinapyl alcohol derivatives; absolute configuration determination; cytotoxicity
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Tian, X.; Ding, G.; Peng, C.; Hu, Y.; Li, L.; Chen, H.; Zou, Z. Sinapyl Alcohol Derivatives from the Lipo-soluble Part of Dichrocephala benthamii C. B. Clarke. Molecules 2013, 18, 1720-1727.

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