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18 pages, 2467 KB  
Article
Physicochemical, Pasting and Thermal Properties of the Starch of Three Varieties of Yam (Dioscorea spp.) as Potential Food Ingredients
by Mildreth Cordero-Herrera, José Benítez-Lobo, Claudia De Paula, Ricardo Andrade-Pizarro, Piedad Montero-Castillo, Diofanor Acevedo-Correa, Jhon Rodríguez-Meza and Alba Durango-Villadiego
Polymers 2026, 18(8), 943; https://doi.org/10.3390/polym18080943 - 12 Apr 2026
Viewed by 166
Abstract
Yam starch accounts for 70–80% of its dry matter, and its physicochemical and technofunctional properties are crucial for its use in the food industry (gelling agent, thickener, and stabilizer). The objective of this study focuses on the physicochemical, pasting and thermal properties of [...] Read more.
Yam starch accounts for 70–80% of its dry matter, and its physicochemical and technofunctional properties are crucial for its use in the food industry (gelling agent, thickener, and stabilizer). The objective of this study focuses on the physicochemical, pasting and thermal properties of starch extracted from the yam varieties Dioscorea cayenensis, Dioscorea alata, and Dioscorea rotundata. The proximal composition, amylose and amylopectin content, as well as their functional properties (absorption index, solubility, swelling, thermal and pasting behavior, morphology, and color) were analyzed. The results showed that the starch extraction yield varied between varieties, being highest in D. cayenensis with 14.14%. D. alata had the highest starch (82.24%) and amylose (34.69%) content, which gives it greater gel firmness and retrogradation potential, as well as the best techno-functional properties water absorption index (2.46 g/g), water solubility index (1.1%), and swelling power (2.54 g/g). D. cayenensis stands out for its high amylopectin content (69.62%) and brightness (96.89), reflecting greater starch whiteness. D. rotundata has an intermediate balance between amylose and amylopectin, which makes it versatile. The proximal composition and techno-functional properties of yam starch position it as a promising raw material for the food industry, especially in the manufacture of thickeners, gelling agents, and in bakery products, pasta and noodles. Full article
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5 pages, 547 KB  
Case Report
Recurrent Hepatic Encephalopathy After Abdominal Surgery in a Non-Cirrhotic Patient: A Case Report
by Sebastiano Ziola, Giuseppe Cittadini, Andrea Pasta, Sara Labanca, Giulia Pieri, Simona Marenco and Edoardo G. Giannini
Reports 2026, 9(2), 112; https://doi.org/10.3390/reports9020112 - 4 Apr 2026
Viewed by 294
Abstract
Background and Clinical Significance: Hepatic encephalopathy (HE) is a reversible brain dysfunction typically associated with cirrhosis and portal hypertension. In these patients, portosystemic shunts allow ammonia and other toxins to bypass hepatic metabolism, leading to neurological symptoms. However, HE can also occur in [...] Read more.
Background and Clinical Significance: Hepatic encephalopathy (HE) is a reversible brain dysfunction typically associated with cirrhosis and portal hypertension. In these patients, portosystemic shunts allow ammonia and other toxins to bypass hepatic metabolism, leading to neurological symptoms. However, HE can also occur in non-cirrhotic patients through congenital shunts or, less commonly, through iatrogenic shunts following abdominal trauma or surgery. This case is clinically significant as it illustrates a rare presentation of recurrent HE caused by a de novo portosystemic shunt following major abdominal surgery in a patient without underlying liver disease. Case Presentation: A 76-year-old male was admitted with confusion, lethargy, and flapping tremors. His medical history included a total pancreatectomy for pancreatic adenocarcinoma six months prior. Laboratory tests revealed hyperammonemia and altered liver enzymes likely related to ongoing chemotherapy, but no signs of hepatic insufficiency or cirrhosis. A review of recent CT imaging identified a new portosystemic shunt between the portal territory and the azygous vein that was absent prior to his pancreatectomy. This iatrogenic shunt likely formed via the re-vascularization of vestigial vessels following surgical de-vascularization. The patient was successfully managed with lactulose and rifaximin. At 3-month follow-up, no further HE episodes had occurred. Conclusions: This case highlights that HE should be considered in patients without cirrhosis presenting with altered mental status and hyperammonemia, especially following abdominal surgery. It underscores the importance of a multidisciplinary approach and meticulous re-evaluation of imaging to identify iatrogenic vascular shunts that may be amenable to medical or interventional management. Full article
(This article belongs to the Section Gastroenterology)
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12 pages, 711 KB  
Article
Does Resistant Starch Formed by Cooling Pasta Decrease the Postprandial Glycemic Response in Type 1 Diabetes? A Randomized Single-Blind Crossover Study
by Anita Rogowicz-Frontczak, Sylwia Strozyk, Stanislaw Pilacinski, Anna Koperska, Joanna Le Thanh-Blicharz, Magdalena Tanska and Dorota Zozulinska-Ziolkiewicz
Nutrients 2026, 18(7), 1152; https://doi.org/10.3390/nu18071152 - 3 Apr 2026
Viewed by 510
Abstract
Background: Carbohydrate quality and culinary processing can meaningfully alter postprandial glycemia in people with type 1 diabetes (T1D). Cooling gelatinized starch promotes retrogradation and increases resistant starch (RS), potentially attenuating postprandial glucose excursions. Objectives: We investigated whether pasta cooled after cooking (24 h [...] Read more.
Background: Carbohydrate quality and culinary processing can meaningfully alter postprandial glycemia in people with type 1 diabetes (T1D). Cooling gelatinized starch promotes retrogradation and increases resistant starch (RS), potentially attenuating postprandial glucose excursions. Objectives: We investigated whether pasta cooled after cooking (24 h at 4 °C) and reheated before consumption improves postprandial glycemia in adults with T1D without increasing hypoglycemia risk under routine insulin pump bolus-calculator dosing. Methods: In this randomized, single-blind, crossover study, 32 adults with T1D treated with continuous subcutaneous insulin infusion (CSII) consumed two standardized pasta-based meals (50 g of available carbohydrate): freshly cooked pasta and cooled/reheated pasta. Participants administered rapid-acting insulin boluses calculated by their pump bolus calculator 10 min before the meal. Interstitial glucose was recorded for 180 min using flash glucose monitoring. Results: Compared with freshly cooked pasta, cooled/reheated pasta produced lower maximum glycemia (10.7 vs. 12.6 mmol/L, p = 0.0001), lower maximum glycemic rise (2.8 vs. 4.7 mmol/L, p < 0.0001), lower incremental area under the curve (iAUC; 211.9 vs. 524.8 mmol/L × 180 min, p < 0.0001), and a shorter time-to-peak (65 vs. 125 min, p = 0.014). Resistant starch content increased after cooling (12.88 ± 0.06 vs. 8.03 ± 0.08 g/100 g). The number of hypoglycemic episodes did not differ between conditions. Conclusions: Cooling and reheating pasta therefore increased RS and attenuated postprandial glycemia in adults with T1D without increasing early postprandial hypoglycemia in the studied setting. Full article
(This article belongs to the Special Issue Nutrition and Behavioral Interventions for Diabetes)
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22 pages, 339 KB  
Article
Sustainable Eating in Saudi Arabia: Associations Between Food Sustainability Knowledge, Attitudes, Food Waste-Related Behaviours, and Dietary Choices Among Adults
by Areej A. Alghamdi, Najlaa M. Aljefree, Israa M. Shatwan and Noha M. Almoraie
Nutrients 2026, 18(7), 1149; https://doi.org/10.3390/nu18071149 - 3 Apr 2026
Viewed by 342
Abstract
Background/Objectives: Sustainable food habits are essential for reducing the environmental impacts of a food system. We investigated food sustainability knowledge, attitudes, and food waste-related behaviours among Saudi adults and assessed their associations with socio-demographic characteristics and dietary choices, which are subjects that [...] Read more.
Background/Objectives: Sustainable food habits are essential for reducing the environmental impacts of a food system. We investigated food sustainability knowledge, attitudes, and food waste-related behaviours among Saudi adults and assessed their associations with socio-demographic characteristics and dietary choices, which are subjects that remain under-researched. Methods: A cross-sectional study was conducted among 855 Saudi adults (≥18 years) using convenience sampling. Data were collected using a validated online questionnaire assessing sustainability knowledge, attitudes, food waste behaviours, dietary choices, and socio-demographic characteristics. Descriptive statistics, chi-square tests, and linear regression analyses were performed using SPSS version 29. Results: Overall, 32% of the study population demonstrated adequate sustainability knowledge, 61% expressed positive attitudes towards food sustainability, and 45% demonstrated favourable food waste management. Women were more knowledgeable than men. Participants who possessed a better understanding of food sustainability consumed more vegetables, fruits, and bread and less processed meat. Those with a positive attitude towards food sustainability exhibited higher consumption of red meat, white meat, eggs, milk, yogurt, cheese, vegetables, fruits, bread, and sweet or savoury snacks. Meanwhile, individuals with better food waste behaviours demonstrated significantly lower consumption of legumes, fish, pasta, red meat, white meat, processed meat, eggs, milk, yogurt, cheese, fruits, bread, and sweet or savoury snacks. Conclusions: Saudi adults possess limited knowledge of sustainability and suboptimal food waste behaviours despite having relatively positive attitudes. These findings highlight opportunities for intervention. Public education, targeted campaigns, and media communication could enhance sustainability awareness and promote healthier, environmentally sustainable dietary patterns. Full article
(This article belongs to the Section Nutrition and Public Health)
15 pages, 684 KB  
Article
Odor-Free Lyophilized Trout (Oncorhynchus mykiss) Powder in Gluten-Free Pasta: Nutritional, Techno-Functional, Sensory and Digestibility Evaluation
by Özlem Emir Çoban, Hülya Gül, Mücahit Eroğlu, Tuba Okutan, İlhan Firat Kilinçer and Feray Çağiran Yilmaz
Foods 2026, 15(7), 1155; https://doi.org/10.3390/foods15071155 - 28 Mar 2026
Viewed by 325
Abstract
Gluten-free (GF) products developed for individuals with celiac disease and gluten sensitivity often suffer from low protein and mineral content. Fish proteins offer a promising solution to address these deficiencies; however, the characteristic “fishy odor” and related technological challenges limit consumer acceptance. This [...] Read more.
Gluten-free (GF) products developed for individuals with celiac disease and gluten sensitivity often suffer from low protein and mineral content. Fish proteins offer a promising solution to address these deficiencies; however, the characteristic “fishy odor” and related technological challenges limit consumer acceptance. This study aimed to develop an innovative GF pasta with improved nutritional density and acceptable sensory quality by incorporating deodorized and lyophilized trout powder. GF pasta formulations were prepared using buckwheat flour, xanthan gum, and 5% or 10% odorless trout powder. Vinegar pretreatment was applied to reduce fish odor, while lyophilization was chosen to minimize nutrient losses. The samples were analyzed for nutritional composition, techno-functional properties, in vitro digestibility, and sensory attributes. Results showed that trout powder significantly increased protein and ash content compared to the control (p < 0.05). A slight darkening was observed in color analysis due to fish pigments and buckwheat phenolics, but overall visual stability remained high. In vitro digestibility revealed enhanced protein digestibility (p < 0.05) and a slight reduction in starch digestibility. Sensory evaluation demonstrated that odor scores (8) at 10% trout inclusion remained close to the control, reversing the commonly reported decline in acceptance with increasing fish content. These findings indicate that combining vinegar pretreatment with lyophilization enables the incorporation of fish proteins into GF pasta without sensory disadvantages, while simultaneously improving nutritional quality. Full article
(This article belongs to the Section Grain)
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11 pages, 742 KB  
Article
Valorizing Oregano Distillation Wastewater in New Pasta Formulations: Physical, Sensory and Chemical Characteristics
by Alessandro Gallina, Maria Concetta Di Bella, Enrica Pistorio, Edoardo Marco Napoli and Maria Grazia Melilli
Foods 2026, 15(6), 1092; https://doi.org/10.3390/foods15061092 - 20 Mar 2026
Viewed by 539
Abstract
The agro-food industry faces significant environmental and economic challenges due to waste production. To promote sustainability, it is essential to valorize agricultural by-products, such as wastewater from essential oil distillation. Despite being a disposal burden, this wastewater retains valuable compounds with high antioxidant [...] Read more.
The agro-food industry faces significant environmental and economic challenges due to waste production. To promote sustainability, it is essential to valorize agricultural by-products, such as wastewater from essential oil distillation. Despite being a disposal burden, this wastewater retains valuable compounds with high antioxidant and antibacterial potential, making it an ideal ingredient for functional foods. Given that pasta and bread are daily staples in the Italian diet, they represent a strategic opportunity to improve public nutritional intake. In this study, a novel pasta formulation was developed by replacing 50% or 100% of the processing water with wastewater derived from oregano distillation. The investigation focused on the quality of the cooking process and the composition of phenolic compounds. A sensory analysis was also conducted to assess consumer acceptance. The enriched pasta demonstrated positive sensory characteristics, with an overall appreciation around 7, and higher levels of phenolic compounds (up to 0.79 mg GAE/g) in relation to the control sample (0.14 mgGAE/g). This highlights the potential of these rich raw materials for use in sustainable food and represents a sustainable strategy to improve the nutritional profile of pasta. Full article
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19 pages, 1296 KB  
Article
Primary Shelf-Life Assessment of Fresh Vegan Spinach Potato-Based Pasta (Gnocchi) Using an Accelerated Test Approach
by Stefano Zardetto, Carlos Gabriel Arp and Gabriella Pasini
Foods 2026, 15(6), 1012; https://doi.org/10.3390/foods15061012 - 12 Mar 2026
Viewed by 274
Abstract
The primary shelf life (PSL) of fresh vegan spinach gnocchi packaged under a modified atmosphere (MAP) was investigated. Microbiological, physicochemical, and sensory properties were monitored during storage at three temperatures (4, 8, and 12 °C). The microbial load remained below the limit considered [...] Read more.
The primary shelf life (PSL) of fresh vegan spinach gnocchi packaged under a modified atmosphere (MAP) was investigated. Microbiological, physicochemical, and sensory properties were monitored during storage at three temperatures (4, 8, and 12 °C). The microbial load remained below the limit considered safe (3 log CFU g−1) in all samples during storage at all tested temperatures. Storage time significantly increased the hardness of uncooked gnocchi (p < 0.05) and the water absorption index (p < 0.05). Moreover, at higher storage temperatures, the kinetic rate of hardness decreased in uncooked gnocchi (0.29 N day−1 at 12 °C vs. 0.35 N day−1 at 4 °C). Conversely, in cooked gnocchi, as the storage temperature increased, the rate of hardness acceleration increased. The sensory analysis results varied according to storage temperature, and the Overall Quality Index (OQI), combined with principal component analysis (PCA), was used to determine PSL values. The Arrhenius relationship successfully described the temperature dependence of reaction rate constants, and the calculated Q10 value (3.0) confirmed hardness as the quality attribute most affected by temperature. OQI showed a strong correlation with cooked-gnocchi hardness, and a sensory cutoff of 6.5 was established and confirmed by the sensory panel. The corresponding hardness rejection value was 12.1 N. The PSL was estimated based on sensory and texture criteria, as microbial quality was not a limiting factor. Under non-isothermal cold-chain conditions, PSL was predicted using the time–temperature tolerance (TTT) approach, yielding a value of 42 ± 3 days. Full article
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18 pages, 712 KB  
Article
Effects of Dry Herbal Supplementation on Microbiological Safety, Physicochemical Characteristics, Sensory Properties, and Shelf Life of Traditional Serbian Rolled Pasta Filata Cheese from Raw Cow’s Milk
by Suzana Vidaković Knežević, Dragana Ljubojević Pelić, Nenad Popov, Slobodan Knežević, Jelena Vranešević, Miloš Pelić and Milica Živkov Baloš
Microorganisms 2026, 14(3), 619; https://doi.org/10.3390/microorganisms14030619 - 10 Mar 2026
Viewed by 375
Abstract
Rolled cheeses are a traditional specialty of the Vojvodina region in Serbia, produced through an artisanal process passed down across generations. This study evaluated the impact of the addition of selected herbs (a mixture of oregano and basil and chives added separately) on [...] Read more.
Rolled cheeses are a traditional specialty of the Vojvodina region in Serbia, produced through an artisanal process passed down across generations. This study evaluated the impact of the addition of selected herbs (a mixture of oregano and basil and chives added separately) on the microbiological, physicochemical, and sensory characteristics of rolled pasta filata cheese. Cheeses, both with and without herbs, were vacuum packed and stored at 4 °C for 60 days. The addition of oregano and basil significantly reduced aerobic mesophilic bacteria, Enterobacteriaceae, and Escherichia coli, while Salmonella spp. and Listeria monocytogenes remained undetectable throughout storage. Physicochemical analyses classified the cheeses as full-fat, semi-hard, with at least 45% milk fat in dry matter, and moisture in fat-free matter between 54% and 69%. All variants exhibited uniform shape, intact appearance, and a compact layered structure, while herbal-enriched cheeses developed a distinctive aroma and flavor. Sensory evaluation showed that all cheese types remained acceptable for up to 40 days, with minor deviations at day 60. Overall, the herbal addition enhanced sensory appeal, created new flavor profiles, and improved microbiological stability, demonstrating its potential as a natural strategy to extend the shelf life of traditional Serbian rolled pasta filata cheese. Full article
(This article belongs to the Section Microbial Biotechnology)
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16 pages, 1346 KB  
Article
Processability of Ancient Wheats for Novel Value Chains and Agro-Food Biodiversity
by Francesca Nocente, Diana DeSantis, Marta Naso, Gaia Blandizzi, Margherita Modesti, Serena Ferri, Gabriele Chilosi and Laura Gazza
Foods 2026, 15(5), 929; https://doi.org/10.3390/foods15050929 - 6 Mar 2026
Viewed by 275
Abstract
Modern wheat breeding has focused on maximizing yields under high-input systems. Although ancient wheat varieties generally show lower yields and no clear nutritional superiority, they are increasingly valued in organic and local food systems for their resilience, cultural identity, and suitability for artisanal [...] Read more.
Modern wheat breeding has focused on maximizing yields under high-input systems. Although ancient wheat varieties generally show lower yields and no clear nutritional superiority, they are increasingly valued in organic and local food systems for their resilience, cultural identity, and suitability for artisanal processing. This study evaluated the physicochemical, rheological, and technological properties of stone-milled flours and semolato from ancient common, durum, and Khorasan wheat to develop artisanal bread and pasta. Ancient cultivars showed relatively high protein content, ranging from 10.9% to 15.9% (on a dry matter basis). Gluten quality was generally weak, with gluten index values below 30% in most cultivars and alveograph W values below 60 × 10−4 J, mainly in durum wheats. Among common wheat cultivars, Autonomia B and Rano Solina showed the best bread-making suitability and were selected to produce bread prototypes via the application of pre-gelatinization. Optimized fermentation and pre-gelatinization significantly improved the crumb structure, softness, and sensory acceptance. Pasta from durum cv. Senatore Cappelli and Khorasan showed good cooking and sensorial quality, with Khorasan receiving a better score for overall acceptability. This study demonstrates that appropriate processing strategies can successfully unlock the technological and sensory potential of ancient wheat varieties, supporting their use in short value chains and enhancing product differentiation. Full article
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32 pages, 2405 KB  
Article
Optimization of Nutrient-Enriched Ravioli Incorporating Elephant Foot Yam Flour and Encapsulated Okra–Moringa Pearls
by Sangeetha Arunachalam, Baskar Rajoo, Harish Karthikeyan Ravi and Sowmiya Murugesan
Appl. Sci. 2026, 16(5), 2435; https://doi.org/10.3390/app16052435 - 3 Mar 2026
Viewed by 797
Abstract
The growing demand for functional and value-added foods has prompted interest in integrating nutrient-rich ingredients and novel encapsulated systems into traditional pasta products. This study aimed to develop and optimize a ravioli dough formulated with elephant foot yam flour (EFYF), wheat flour (WF) [...] Read more.
The growing demand for functional and value-added foods has prompted interest in integrating nutrient-rich ingredients and novel encapsulated systems into traditional pasta products. This study aimed to develop and optimize a ravioli dough formulated with elephant foot yam flour (EFYF), wheat flour (WF) and amaranth flour (AF) using mixture design in response surface methodology and to create an innovative filling using encapsulated edible pearls produced from okra mucilage and moringa leaf powder through ionotropic gelation. The pearls and ravioli dough were analyzed for physicochemical, textural, color and nutritional characteristics. Cooked ravioli was investigated for cooking quality and sensory attributes. The optimized dough formulation (46.67 g EFYF, 43.32 g WF, 10 g AF) exhibited desirable hardness (4.64 ± 0.28 N), chewiness (0.40 ± 0.02 N), nutritional, physicochemical and color attributes. The edible pearls demonstrated moderate moisture content (21.18 ± 0.26%), high protein (26.25 ± 0.02%), crude fiber (2.60 ± 0.01%), dietary fiber (8.60 ± 0.52%), high ash content (14 ± 0.62%) and soft gel-like texture. The cooked ravioli showed a cooking time of 8 ± 1 min, high water absorption capacity (209.9 ± 0.34%), minimal solid loss (1.30 ± 0.21%) and favorable sensory scores across appearance, taste, texture and overall acceptability. The study concludes that incorporating encapsulated pearls and nutrient-dense flours can produce a functional, nutritionally enriched ravioli with good technological performance and consumer appeal. Full article
(This article belongs to the Section Food Science and Technology)
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17 pages, 2212 KB  
Article
Effects of Almond and Tomato By-Products on a Newly Developed Gluten-Free Rice Pasta Processed via Extrusion-Cooking
by Hind Benchettah, Abdallah Bouasla, Agnieszka Wójtowicz, Ahlem Dib, Maciej Combrzyński, Jakub Soja, Marcin Mitrus and Leila Benatallah
Appl. Sci. 2026, 16(5), 2283; https://doi.org/10.3390/app16052283 - 26 Feb 2026
Viewed by 362
Abstract
Industrial almond by-products (ABPs, almond oil cake) and tomato by-products (TBPs, mixture of peel and seeds) are nutrient-rich residues that could enhance the nutritional value of gluten-free pasta and support sustainable waste reduction. This study investigated the impacts of ABP or TBP incorporation [...] Read more.
Industrial almond by-products (ABPs, almond oil cake) and tomato by-products (TBPs, mixture of peel and seeds) are nutrient-rich residues that could enhance the nutritional value of gluten-free pasta and support sustainable waste reduction. This study investigated the impacts of ABP or TBP incorporation and the extrusion screw speed on rice-based pasta quality. Rice pasta (control) and pasta enriched with ABP or TBP at different rates (2.5%, 5.0%, 7.5% and 10.0%) were processed by extrusion-cooking at two screw speeds (50 and 90 rpm), and their quality (cooking loss, water absorption capacity, hardness, firmness, adhesiveness and color) was evaluated, as well as energy requirements during processing (specific mechanical energy (SME)). The results showed that an increase in the ABP and TBP rates had a more pronounced positive effect on cooking loss, water absorption capacity, yellowness and redness values. Moreover, comparable hardness and firmness, but lower adhesiveness values, were recorded in cooked rice–ABP-enriched pasta. However, cooked pasta enriched with TBP had lower hardness than the control pasta. Regarding energy consumption, pasta processed with a higher by-product rate at a higher screw speed showed similar SME as compared to the control pasta. In this regard, ABP can be used successfully from 7.5 to 10.0% in rice–ABP pasta formulations without compromising its technological properties. However, the optimization of the additive rate of TBP requires further study. Full article
(This article belongs to the Section Food Science and Technology)
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12 pages, 981 KB  
Review
Pathogenesis of Shoulder Calcific Tendinopathy
by Rami Kaplan, Micaela Berni, Laura Caliogna, Greta Dei Rossi, Camilla Torriani, Eugenio Jannelli, Mario Mosconi, Federico Alberto Grassi and Gianluigi Pasta
Int. J. Mol. Sci. 2026, 27(5), 2178; https://doi.org/10.3390/ijms27052178 - 26 Feb 2026
Viewed by 658
Abstract
Shoulder calcific tendinopathy is a common condition affecting adults and is has a higher incidence in women. This condition is due to a multifactorial process and is characterized by the deposition of hydroxyapatite crystals in the rotator cuff tendons. The disease shows a [...] Read more.
Shoulder calcific tendinopathy is a common condition affecting adults and is has a higher incidence in women. This condition is due to a multifactorial process and is characterized by the deposition of hydroxyapatite crystals in the rotator cuff tendons. The disease shows a phenotypic transformation of tenocytes into chondrocyte-like cells, likely caused by metabolic and inflammatory changes and mechanical stress. Risk factors promoting this pathology include hyperlipidemia, advanced age, diabetes, female gender, and thyroid dysfunction. Recent studies highlight that metalloproteinases, oxidative stress, inflammatory mediators, bone morphogenetic proteins (BMPs), genetic and post-transcriptional alterations play a significant role in the pathogenesis of the disease. New therapeutic strategies are currently available that aim to modulate inflammation, osteogenic differentiation, and calcium homeostasis, showing promising results, especially in preclinical models. The aim of this review is to explore the different pathogenetic mechanisms and highlight future therapeutic developments for the treatment of shoulder calcification. Full article
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14 pages, 412 KB  
Study Protocol
Randomized, Double-Blind, Crossover Trial Comparing Low-Glycemic Index Functional and Conventional Wholegrain Carbohydrates on Glycolipid Metabolism and Vascular Stress Markers in Adults with Suboptimal Triglyceridemia: The GLOW Study
by Marina Giovannini, Federica Fogacci, Cristina Scollo, Valentina Di Micoli, Elisa Grandi and Arrigo F. G. Cicero
J. Clin. Med. 2026, 15(5), 1745; https://doi.org/10.3390/jcm15051745 - 25 Feb 2026
Viewed by 505
Abstract
Mild fasting hypertriglyceridemia is often accompanied by early insulin resistance and atherogenic dyslipidemia, making it an attractive target for pragmatic dietary prevention. This trial aims to determine whether substituting common cereal-based staples with functional low-glycemic index (low-GI) products improves the triglyceride–glucose (TyG) index [...] Read more.
Mild fasting hypertriglyceridemia is often accompanied by early insulin resistance and atherogenic dyslipidemia, making it an attractive target for pragmatic dietary prevention. This trial aims to determine whether substituting common cereal-based staples with functional low-glycemic index (low-GI) products improves the triglyceride–glucose (TyG) index in adults with fasting triglycerides >150 mg/dL. The GLOW study is an exploratory, randomized, double-blind, single-center crossover trial. Adults aged ≥18 years with fasting triglycerides >150 mg/dL and body mass index ≤30 kg/m2 will be enrolled. Participants will follow a stabilized Mediterranean-style diet and will complete two 28-day intervention periods in random sequence: (i) functional low-GI Altograno® pasta, pizza base and flatbread; and (ii) conventional standard wholegrain products. Intervention periods will be separated by a 28-day washout. Study foods will be consumed as fixed daily substitutions of usual staple servings (one bread portion and one pasta or pizza portion). The primary endpoint is the between-intervention difference in TyG response over each period, defined as the period-specific change from the corresponding period baseline to the end-of-period assessment. The primary analysis will compare end-of-period TyG between interventions while adjusting for the period-specific baseline value. Secondary endpoints include fasting triglycerides and glucose, atherogenic lipoproteins (non–high-density lipoprotein cholesterol and apolipoprotein B), inflammation (high-sensitivity C-reactive protein), endothelial reactivity assessed with the Endocheck®/Vicorder® system, and food acceptability. Safety endpoints include adverse event recording. Treatment effects will be estimated using linear mixed-effects models accounting for treatment, period and sequence, with prespecified carryover sensitivity analyses. A total of 40 participants will be recruited to generate feasibility data and effect size estimates. This protocol will provide crossover evidence on whether pragmatic, product-level low-GI staple substitution improves TyG and related cardiometabolic and vascular biomarkers in adults with suboptimal triglyceridemia, informing larger trials. Trial registration: ClinicalTrials.gov NCT07198789. Full article
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21 pages, 635 KB  
Article
A New Insight into Ancient Wheat Pasta: Physicochemical, Technological and Cooking Quality of Triticum dicoccum (Emmer)
by İzzet Özhamamcı
Appl. Sci. 2026, 16(4), 2138; https://doi.org/10.3390/app16042138 - 22 Feb 2026
Viewed by 469
Abstract
Emmer (Triticum turgidum ssp. dicoccum) is attracting renewed interest as a nutrient-dense ancient wheat for sustainable cereal foods; however, product-level evidence for region-specific landraces remains limited. This study characterizes pasta produced exclusively from 100% Triticum dicoccum semolina cultivated in Ardahan (Türkiye) [...] Read more.
Emmer (Triticum turgidum ssp. dicoccum) is attracting renewed interest as a nutrient-dense ancient wheat for sustainable cereal foods; however, product-level evidence for region-specific landraces remains limited. This study characterizes pasta produced exclusively from 100% Triticum dicoccum semolina cultivated in Ardahan (Türkiye) by integrating proximate composition, cooking performance, and instrumental texture (TPA). The emmer pasta contained 12.70% protein, 4.93% total dietary fiber, and 1.68% ash, with an energy value of 366.25 kcal/100 g. Cooking tests revealed 10.86% cooking loss, 219.98% water absorption, and 101.62% volume increase, indicating limited cooking tolerance consistent with a weaker starch–protein matrix. In comparison with conventional T. durum pasta, cooked emmer pasta exhibited comparable hardness, gumminess, and chewiness, but higher adhesiveness and springiness alongside lower resilience and cohesiveness. These results highlight Ardahan-grown T. dicoccum as a nutritionally valuable pasta raw material, albeit with technological constraints (particularly cooking loss) that warrant further optimization for industrial use. Full article
(This article belongs to the Section Food Science and Technology)
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26 pages, 2220 KB  
Article
A Structured Analytical Framework to Facilitate EU Food Exports to the USA: A Case Study Analyzing Barriers and Support Strategies
by Andrea Gori, Valentina Garretto, Paola Vannucci, Gaetano Liuzzo, Giovanni Munaò, Lara Tinacci, Roberta Nuvoloni and Andrea Armani
Foods 2026, 15(4), 761; https://doi.org/10.3390/foods15040761 - 19 Feb 2026
Viewed by 299
Abstract
Exporting food products from the European Union (EU) to the United States of America (USA) involves navigating complex regulations and procedural barriers that hinder market access. Italian food businesses (FBs), particularly small and medium-sized enterprises (SMEs), often face difficulties accessing clear guidance, as [...] Read more.
Exporting food products from the European Union (EU) to the United States of America (USA) involves navigating complex regulations and procedural barriers that hinder market access. Italian food businesses (FBs), particularly small and medium-sized enterprises (SMEs), often face difficulties accessing clear guidance, as national procedures are scattered across multiple sources. This paper proposes a structured three-step analytical framework to support EU FBs: product-specific analysis, identification of relevant EU and USA legislation, comparative legislative analysis via concordance tables, and identification of procedures to integrate into the Food Safety Management System. The framework was applied to an Italian medium-sized FB exporting pork-based pasta sauce to the USA. Beyond the specific case study, the proposed analytical framework was designed to be transferable and adaptable to other food categories and destination markets, providing a structured methodological tool to support regulatory alignment. In this sense, the framework can be considered product-independent but process-specific. As such, it can support both FBs and Competent Authorities in conducting risk-based assessments of regulatory equivalence and export compliance. Results indicated the need for Sanitation Standard Operating Procedures (SSOPs), thermal process validation, direct verification activities, and pre-shipment review. Findings emphasize that operational and procedural barriers disproportionately affect SMEs, highlighting the importance of targeted support to facilitate market access and strengthen certification systems. Full article
(This article belongs to the Section Food Quality and Safety)
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