Skip to Content

794 Results Found

  • Article
  • Open Access
8 Citations
5,407 Views
13 Pages

Application of the JA-CHRODIS Integrated Multimorbidity Care Model (IMCM) to a Case Study of Diabetes and Mental Health

  • Maria João Forjaz,
  • Carmen Rodriguez-Blazquez,
  • Inmaculada Guerrero-Fernández de Alba,
  • Antonio Gimeno-Miguel,
  • Kevin Bliek-Bueno,
  • Alexandra Prados-Torres and
  • on behalf of the CHRODIS Expert Group on Multimorbidity

The Integrated Multimorbidity Care Model (IMCM), developed by the Joint Action on Chronic Diseases and Promoting Healthy Ageing across the Life Cycle (JA-CHRODIS), proposes a set of 16 multidimensional components (i.e., recommendations) to improve th...

  • Article
  • Open Access
28 Citations
4,512 Views
13 Pages

Multimorbidity and Complex Multimorbidity in India: Findings from the 2017–2018 Longitudinal Ageing Study in India (LASI)

  • Abhinav Sinha,
  • Sushmita Kerketta,
  • Shishirendu Ghosal,
  • Srikanta Kanungo,
  • John Tayu Lee and
  • Sanghamitra Pati

Complex multimorbidity refers to the co-occurrence of three or more chronic illnesses across >2 body systems, which may identify persons in need of additional medical support and treatment. There is a scarcity of evidence on the differences in pat...

  • Article
  • Open Access
14 Citations
4,420 Views
16 Pages

Multimorbidity is defined as the coexistence of multiple chronic conditions in one person. It affects the way people lead their lives and might be a heavy burden, especially for those with limited material resources. This study explores the prevalenc...

  • Article
  • Open Access
3 Citations
2,439 Views
8 Pages

11 July 2024

Objectives: To examine the longitudinal relationship between edentulism, nutritional intake, and the progress of multimorbidity among older Americans. Methods: We used data from the Health and Retirement Study (2006–2018), a longitudinal survey...

  • Article
  • Open Access
9 Citations
1,892 Views
15 Pages

Multimorbidity Patterns in the Urban Population in Poland

  • Małgorzata Chlabicz,
  • Jacek Jamiołkowski,
  • Paweł Sowa,
  • Magdalena Zalewska,
  • Łukasz Kiszkiel,
  • Mariusz Ciołkiewicz,
  • Radosław Motkowski,
  • Irina Kowalska,
  • Łukasz Minarowski and
  • Karol A. Kamiński

8 September 2023

A number of studies have been conducted on multimorbidity; however, there are different patterns in various countries, ethnicities and social groups. The aim of this study is to estimate the prevalence of multimorbidity (physical diseases) in the urb...

  • Article
  • Open Access
1 Citations
1,100 Views
24 Pages

Sex-Specific Multimorbidity–Multibehaviour Patterns in Primary Care Populations

  • Konstantinos Spyropoulos,
  • Naomi J. Ellis and
  • Christopher J. Gidlow

Background: A conceptual shift in healthcare emphasises multimorbidity and multibehaviours as interconnected phenomena, highlighting dose–response associations and sex-specific differences. Data-driven approaches have been suggested for overcom...

  • Article
  • Open Access
2,233 Views
18 Pages

Prevalence of Multimorbidity in Lithuania: Insights from National Health Insurance Fund Data

  • Dovilė Ramanauskaitė,
  • Roma Puronaitė,
  • Audronė Jakaitienė and
  • Sigita Glaveckaitė

(1) Background: As the burden of multimorbidity is increasing worldwide, little is known about its prevalence in Lithuania. We aimed to estimate the prevalence of chronic conditions and multimorbidity among Lithuanian adults and assess their impact o...

  • Article
  • Open Access
20 Citations
10,371 Views
12 Pages

The Association of Healthy Aging with Multimorbidity: IKARIA Study

  • Alexandra Foscolou,
  • Christina Chrysohoou,
  • Kyriakos Dimitriadis,
  • Konstantina Masoura,
  • Georgia Vogiatzi,
  • Viktor Gkotzamanis,
  • George Lazaros,
  • Costas Tsioufis and
  • Christodoulos Stefanadis

20 April 2021

The aim of this study was to evaluate several sociodemographic, lifestyle, and clinical characteristics of the IKARIA study participants and to find healthy aging trajectories of multimorbidity of Ikarian islanders. During 2009, 1410 people (aged 30+...

  • Review
  • Open Access
81 Citations
7,048 Views
12 Pages

Multimorbidity, Loneliness, and Social Isolation. A Systematic Review

  • André Hajek,
  • Benedikt Kretzler and
  • Hans-Helmut König

No systematic review has appeared so far synthesizing the evidence regarding multimorbidity and loneliness, social isolation, or social frailty. Consequently, our aim was to fill this gap. Three electronic databases (PubMed, PsycINFO, and CINAHL) wer...

  • Review
  • Open Access
30 Citations
5,217 Views
12 Pages

The Role of Artificial Intelligence in Managing Multimorbidity and Cancer

  • Alfredo Cesario,
  • Marika D’Oria,
  • Riccardo Calvani,
  • Anna Picca,
  • Antonella Pietragalla,
  • Domenica Lorusso,
  • Gennaro Daniele,
  • Franziska Michaela Lohmeyer,
  • Luca Boldrini and
  • Giovanni Scambia
  • + 3 authors

19 April 2021

Traditional healthcare paradigms rely on the disease-centered approach aiming at reducing human nature by discovering specific drivers and biomarkers that cause the advent and progression of diseases. This reductive approach is not always suitable to...

  • Article
  • Open Access
54 Citations
6,509 Views
13 Pages

Multimorbidity among Two Million Adults in China

  • Xiaowen Wang,
  • Shanshan Yao,
  • Mengying Wang,
  • Guiying Cao,
  • Zishuo Chen,
  • Ziting Huang,
  • Yao Wu,
  • Ling Han,
  • Beibei Xu and
  • Yonghua Hu

To explore the multimorbidity prevalence and patterns among middle-aged and older adults from China. Data on thirteen chronic diseases were collected from 2,097,150 participants aged over 45 years between January 1st 2011 and December 31st 2015 from...

  • Article
  • Open Access
8 Citations
3,253 Views
9 Pages

24 July 2019

Multimorbidity and suicide rates are rising simultaneously among Korean adults. To address this issue, we assessed the association between multimorbidity and suicidal behavior among adults aged ≥19 years in Korea. We analyzed the data from the 201...

  • Review
  • Open Access
54 Citations
5,341 Views
12 Pages

Definitions and Prevalence of Multimorbidity in Large Database Studies: A Scoping Review

  • Ying Pin Chua,
  • Ying Xie,
  • Poay Sian Sabrina Lee and
  • Eng Sing Lee

Background: Multimorbidity presents a key challenge to healthcare systems globally. However, heterogeneity in the definition of multimorbidity and design of epidemiological studies results in difficulty in comparing multimorbidity studies. This scopi...

  • Article
  • Open Access
48 Citations
5,287 Views
14 Pages

Associations between Multimorbidity and Physical Performance in Older Chinese Adults

  • Shan-Shan Yao,
  • Xiangfei Meng,
  • Gui-Ying Cao,
  • Zi-Ting Huang,
  • Zi-Shuo Chen,
  • Ling Han,
  • Kaipeng Wang,
  • He-Xuan Su,
  • Yan Luo and
  • Beibei Xu
  • + 1 author

Background: Evidence on the association between physical performance and multimorbidity is scarce in Asia. This study aimed to identify multimorbidity patterns and their association with physical performance among older Chinese adults. Methods: Indiv...

  • Article
  • Open Access
51 Citations
5,898 Views
11 Pages

Multimorbidity Patterns and Unplanned Hospitalisation in a Cohort of Older Adults

  • Roselyne Akugizibwe,
  • Amaia Calderón-Larrañaga,
  • Albert Roso-Llorach,
  • Graziano Onder,
  • Alessandra Marengoni,
  • Alberto Zucchelli,
  • Debora Rizzuto and
  • Davide L. Vetrano

10 December 2020

The presence of multiple chronic conditions (i.e., multimorbidity) increases the risk of hospitalisation in older adults. We aimed to examine the association between different multimorbidity patterns and unplanned hospitalisations over 5 years. To th...

  • Article
  • Open Access
2 Citations
3,597 Views
11 Pages

Background: To examine the association between allostatic load and the progression of multimorbidity and the role of socioeconomic factors among older Americans. Methods: Data from the Health and Retirement Study (HRS), a longitudinal study of older...

  • Article
  • Open Access
11 Citations
3,501 Views
12 Pages

Multimorbidity Analysis of 13 Systemic Diseases in Northeast China

  • Jianxing Yu,
  • Fangying Song,
  • Yingying Li,
  • Zhou Zheng,
  • Huanhuan Jia,
  • Yuzhe Sun,
  • Lina Jin and
  • Xihe Yu

Background: Multimorbidity not only affects the quality of patients’ lives, but can also bring a heavy economic burden to individuals, families and society. The purpose of this study was to reveal the connections between diseases, especially th...

  • Review
  • Open Access
3 Citations
5,336 Views
21 Pages

Multimorbidity Management: A Scoping Review of Interventions and Health Outcomes

  • Kagiso P. Seakamela,
  • Reneilwe G. Mashaba,
  • Cairo B. Ntimana,
  • Chodziwadziwa W. Kabudula and
  • Tholene Sodi

Multimorbidity, defined as the co-occurrence of two or more chronic conditions in an individual, has emerged as a worldwide public health concern contributing to mortality and morbidity. This complex health phenomenon is becoming increasingly prevale...

  • Article
  • Open Access
100 Citations
7,209 Views
12 Pages

Trends in the Prevalence of Cardiometabolic Multimorbidity in the United States, 1999–2018

  • Xunjie Cheng,
  • Tianqi Ma,
  • Feiyun Ouyang,
  • Guogang Zhang and
  • Yongping Bai

Cardiometabolic multimorbidity (co-existence of ≥1 cardiometabolic diseases) is increasingly common, while its prevalence in the U.S. is unknown. We utilized data from 10 National Health and Nutrition Examination Survey (NHANES) two-year cycles in...

  • Article
  • Open Access
4 Citations
2,557 Views
11 Pages

Musculoskeletal Diseases as the Most Prevalent Component of Multimorbidity: A Population-Based Study

  • Nina Rajovic,
  • Slavisa Zagorac,
  • Andja Cirkovic,
  • Bojana Matejic,
  • Danilo Jeremic,
  • Radica Tasic,
  • Jelena Cumic,
  • Srdjan Masic,
  • Jovana Grupkovic and
  • Boris Gluscevic
  • + 2 authors

24 May 2024

Background/Objectives: Due to their high frequency, common risk factors, and similar pathogenic mechanisms, musculoskeletal disorders (MSDs) are more likely to occur with other chronic illnesses, making them a “component disorder“ of mult...

  • Review
  • Open Access
18 Citations
7,108 Views
21 Pages

Aortic Stiffness: A Major Risk Factor for Multimorbidity in the Elderly

  • Filippos Triposkiadis,
  • Andrew Xanthopoulos,
  • Konstantinos Lampropoulos,
  • Alexandros Briasoulis,
  • Pantelis Sarafidis,
  • John Skoularigis and
  • Harisios Boudoulas

16 March 2023

Multimorbidity, the coexistence of multiple health conditions in an individual, has emerged as one of the greatest challenges facing health services, and this crisis is partly driven by the aging population. Aging is associated with increased aortic...

  • Article
  • Open Access
16 Citations
3,736 Views
13 Pages

Socioeconomic Position, Multimorbidity and Mortality in a Population Cohort: The HUNT Study

  • Kristin Hestmann Vinjerui,
  • Johan H. Bjorngaard,
  • Steinar Krokstad,
  • Kirsty A. Douglas and
  • Erik R. Sund

26 August 2020

Multimorbidity and socioeconomic position are independently associated with mortality. We investigated the association of occupational position and several multimorbidity measures with all-cause mortality. A cohort of people aged 35 to 75 years who p...

  • Review
  • Open Access
5 Citations
2,719 Views
15 Pages

9 February 2024

The growing prevalence of multimorbidity places a strain on primary healthcare globally. The current study’s aim was to identify, appraise, and synthesize published qualitative longitudinal research on individuals’ experiences concerning...

  • Article
  • Open Access
2,317 Views
10 Pages

23 May 2025

Objectives: The objective of this study was to examine the relationship between multimorbidity and root caries among older American adults. Methods: Data from the National Health and Nutrition Examination Survey (NHANES) 2017–2020, a cross-sect...

  • Article
  • Open Access
424 Views
15 Pages

12 January 2026

Background: Multimorbidity (the co-occurrence of two or more chronic conditions) is increasingly common among older adults and contributes to diminished well-being and greater healthcare use. While national data highlight regional variation, few stud...

  • Article
  • Open Access
1 Citations
2,149 Views
16 Pages

Impact of Vaccination on the Course and Outcome of COVID-19 in Patients with Multimorbidity

  • Kirill Lomonosov,
  • Alyona Lomonosova,
  • Alla Mindlina,
  • Roman Polibin,
  • Maksim Antipov and
  • Gleb Grimm

7 November 2023

Vaccination is the most cost-effective method of preventing COVID-19; however, data on its effect on patients with multimorbidity is limited. The aim was to evaluate the effect of vaccination against new coronavirus infection (NCI) in patients with m...

  • Article
  • Open Access
9 Citations
3,129 Views
11 Pages

Is Transient and Persistent Poverty Harmful to Multimorbidity?: Model Testing Algorithms

  • Sukyong Seo,
  • Young Dae Kwon,
  • Ki-Bong Yoo,
  • Yejin Lee and
  • Jin-Won Noh

Multimorbidity, the coexistence of two or more long-term medical conditions in one person, has been known to disproportionally affect the low-income population. Little is known about whether long-term income is more crucial for multimorbidity than in...

  • Review
  • Open Access
36 Citations
5,873 Views
21 Pages

16 November 2022

Multimorbidity and frailty are highly prevalent in older people with diabetes. This high prevalence is likely due to a combination of ageing and diabetes-related complications and other diabetes-associated comorbidities. Both multimorbidity and frail...

  • Article
  • Open Access
27 Citations
4,174 Views
15 Pages

Multimorbidity Clusters in the Oldest Old: Results from the EpiChron Cohort

  • Ignatios Ioakeim-Skoufa,
  • Mercedes Clerencia-Sierra,
  • Aida Moreno-Juste,
  • Carmen Elías de Molins Peña,
  • Beatriz Poblador-Plou,
  • Mercedes Aza-Pascual-Salcedo,
  • Francisca González-Rubio,
  • Alexandra Prados-Torres and
  • Antonio Gimeno-Miguel

Multimorbidity is challenging for both patients and healthcare systems due to its increasing prevalence and high impact on people’s health and well-being. The risk of multimorbidity increases with age, but there is still more to discover regard...

  • Review
  • Open Access
22 Citations
5,288 Views
16 Pages

Objective: This study aimed to analyze the progression and trends of multimorbidity in the elderly in China and internationally from a bibliometric perspective, and compare their differences on hotspots and research fronts. Methods: Publications betw...

  • Article
  • Open Access
1 Citations
1,148 Views
13 Pages

Prevalence of Multimorbidity Among School-Aged Children in the Yangzhou District of China

  • Jinhan Wang,
  • Qian Zhou,
  • Ying Zhang,
  • Zhuoqi Lai,
  • Weiwei Zhu,
  • Jun Jia,
  • Yongquan Yu and
  • Lihong Yin

Background: Health issues among school-age children have emerged as a global public health concern. These conditions often do not occur in isolation but tend to cluster, indicating a widespread issue of multimorbidity among this population. This stud...

  • Article
  • Open Access
831 Views
12 Pages

The Impact of Multimorbidity on Capacity and Performance Levels: Insights from a Population-Based Study

  • Marina Carvalho Arruda Barreto,
  • Ricardo Goes de Aguiar,
  • Ricardo Cartes-Velásquez and
  • Shamyr Sulyvan de Castro

Multimorbidity has emerged as a pressing public health concern on a global scale, primarily driven by population aging and the epidemiological transition, which has resulted in an increased prevalence of chronic non-communicable diseases. Objective:...

  • Article
  • Open Access
12 Citations
7,039 Views
9 Pages

Although current models of care are generally well-suited to providing treatment for individual medical conditions, the emergence of multimorbidity is becoming a serious concern for practitioners and policy researchers, particularly in developing cou...

  • Systematic Review
  • Open Access
4 Citations
2,864 Views
15 Pages

Charting the Pathways of Cardiometabolic Multimorbidity: A Systematic Review of Clinical Trajectories

  • Ignatios Ioakeim-Skoufa,
  • Rubén Ledesma-Calvo,
  • Aida Moreno-Juste,
  • Fátima Roque,
  • Kerry Atkins,
  • Miguel Ángel Hernández-Rodríguez,
  • Mercedes Aza-Pascual-Salcedo,
  • Francisca González-Rubio,
  • Carmen Lasala-Aza and
  • Jorge Vicente-Romero
  • + 4 authors

11 April 2025

Background: Managing multimorbidity is a major challenge for healthcare systems. Cardiometabolic multimorbidity (CMM) is highly prevalent and linked to increased disease burden, functional decline, and mortality. While most studies focus on cross-sec...

  • Article
  • Open Access
18 Citations
2,654 Views
13 Pages

Family-Level Multimorbidity among Older Adults in India: Looking through a Syndemic Lens

  • Sanghamitra Pati,
  • Abhinav Sinha,
  • Shishirendu Ghosal,
  • Sushmita Kerketta,
  • John Tayu Lee and
  • Srikanta Kanungo

Most evidence on multimorbidity is drawn from an individual level assessment despite the fact that multimorbidity is modulated by shared risk factors prevailing within the household environment. Our study reports the magnitude of family-level multimo...

  • Article
  • Open Access
6 Citations
1,998 Views
12 Pages

29 October 2022

Fractures of the femoral neck are one of the most common reasons for admission to an orthopedic institute. These patients also show multimorbidity (≥2 chronic conditions) and polytherapy (≥5 drugs). Multimorbidity and polytherapy are associated with...

  • Review
  • Open Access
9 Citations
3,234 Views
10 Pages

Background: There has not been a review that evaluated the prevalence of multimorbidity in the Middle East. This review aims to measure the prevalence, demographic factors, and consequences of multimorbidity in the Middle East region. Study Design: A...

  • Article
  • Open Access
34 Citations
8,646 Views
15 Pages

Patterns and Determinants of Multimorbidity in Older Adults: Study in Health-Ecological Perspective

  • Yiming Chen,
  • Lei Shi,
  • Xiao Zheng,
  • Juan Yang,
  • Yaqing Xue,
  • Shujuan Xiao,
  • Benli Xue,
  • Jiachi Zhang,
  • Xinru Li and
  • Chichen Zhang
  • + 2 authors

(1) Background: Multimorbidity has become one of the key issues in the public health sector. This study aims to explore the patterns and health-ecological factors of multimorbidity in China to propose policy recommendations for the management of chro...

  • Feature Paper
  • Article
  • Open Access
44 Citations
5,460 Views
9 Pages

Social Vulnerability in Patients with Multimorbidity: A Cross-Sectional Analysis

  • Tu N. Nguyen,
  • Patrice Ngangue,
  • Tarek Bouhali,
  • Bridget L. Ryan,
  • Moira Stewart and
  • Martin Fortin

Background: Social aspects play an important role in individual health and should be taken into consideration in the long-term care for people with multimorbidity. Purposes: To describe social vulnerability, to examine its correlation with the number...

  • Article
  • Open Access
52 Citations
9,448 Views
12 Pages

How Does Sex Influence Multimorbidity? Secondary Analysis of a Large Nationally Representative Dataset

  • Karolina Agur,
  • Gary McLean,
  • Kate Hunt,
  • Bruce Guthrie and
  • Stewart W. Mercer

Multimorbidity increases with age and is generally more common in women, but little is known about sex effects on the “typology” of multimorbidity. We have characterized multimorbidity in a large nationally representative primary care dataset in term...

  • Article
  • Open Access
2 Citations
3,282 Views
8 Pages

Association between Multimorbidity and COVID-19 Mortality in Qatar: A Cross-Sectional Study

  • Khalid AbouGalala,
  • Basant Elsayed,
  • Mohamed Elmarasi,
  • Mona Kotob,
  • Reham Taha,
  • Fardous Abbasher,
  • Ahmed Amarah,
  • Mariam El Hamawi,
  • Soha S. Albayat and
  • Mohamed M. Emara
  • + 9 authors

20 February 2023

This study assessed the association between multimorbidity and mortality from COVID-19 in the Middle East and North Africa region, where such data are scarce. We conducted a cross-sectional study using data of all cases with COVID-19 reported to the...

  • Article
  • Open Access
935 Views
18 Pages

Metabolomics in the Context of Exercise in Subjects with Multimorbidity: A Pilot Study

  • Rebecca Bankamp,
  • Simone Schweda,
  • Nils Janzen,
  • Andreas M. Nieß,
  • Inga Krauß and
  • Barbara Munz

20 October 2025

Lifestyle-related diseases, such as overweight/obesity, diabetes mellitus type 2 (T2DM), cardiovascular disease, or osteoarthritis, are a major health burden in Western societies. Due to common risk factors, most patients suffer from multimorbidity,...

  • Article
  • Open Access
21 Citations
4,662 Views
12 Pages

Association between Sense of Loneliness and Quality of Life in Older Adults with Multimorbidity

  • Anna Vespa,
  • Roberta Spatuzzi,
  • Paolo Fabbietti,
  • Mirko Di Rosa,
  • Anna Rita Bonfigli,
  • Andrea Corsonello,
  • Pisana Gattafoni and
  • Maria Velia Giulietti

Background: Multimorbidity has been associated with adverse health outcomes, such as reduced physical function, poor quality-of-life (QoL), poor self-rated health. Objective: The association between quality of life, social support, sense of lonelines...

  • Article
  • Open Access
21 Citations
5,173 Views
10 Pages

1 February 2021

To enhance the life satisfaction of the elderly with multimorbidity, it is necessary to investigate the relevant factors and to examine the differences in factors according to gender. The aim of this study was to identify factors affecting life satis...

  • Article
  • Open Access
5 Citations
2,788 Views
10 Pages

Temporal Trend of Multimorbidity of Noncommunicable Diseases among Brazilian Adults, 2006–2021

  • Thaís C. M. Caldeira,
  • Taciana M. Sousa,
  • Marcela M. Soares,
  • Izabella P. A. Veiga,
  • Luiza E. S. Silva and
  • Rafael M. Claro

14 March 2023

We aimed to identify the temporal trend of multimorbidity of noncommunicable disease (NCDs) among Brazilian adults (n = 784,479) over a 16-year period of time. This is a time series of cross-sectional studies based on data from the Surveillance Syste...

  • Article
  • Open Access
14 Citations
3,770 Views
12 Pages

Trends of Multimorbidity Patterns over 16 Years in Older Taiwanese People and Their Relationship to Mortality

  • Hsin-En Ho,
  • Chih-Jung Yeh,
  • James Cheng-Chung Wei,
  • Wei-Min Chu and
  • Meng-Chih Lee

Understanding multimorbidity patterns is important in finding a common etiology and developing prevention strategies. Our aim was to identify the multimorbidity patterns of Taiwanese people aged over 50 years and to explore their relationship with he...

  • Review
  • Open Access
78 Citations
11,147 Views
23 Pages

AI and Big Data in Healthcare: Towards a More Comprehensive Research Framework for Multimorbidity

  • Ljiljana Trtica Majnarić,
  • František Babič,
  • Shane O’Sullivan and
  • Andreas Holzinger

14 February 2021

Multimorbidity refers to the coexistence of two or more chronic diseases in one person. Therefore, patients with multimorbidity have multiple and special care needs. However, in practice it is difficult to meet these needs because the organizational...

  • Article
  • Open Access
5 Citations
2,900 Views
12 Pages

14 November 2024

Background/Objectives: Multimorbidity, defined as two or more chronic diseases co-occurring in an individual, has been linked to elevated healthcare utilization and out-of-pocket expenses. Yet, the barriers to healthcare access due to the health prof...

  • Article
  • Open Access
1,238 Views
10 Pages

Perceived Discrimination Is a Mediator of Rural Identity and Cardiometabolic Multimorbidity Among U.S. Adults

  • LaToya J. O’Neal,
  • Lisa Scarton,
  • Ara Jo,
  • Biswadeep Dhar,
  • Folakemi T. Odedina and
  • Diana J. Wilkie

The rise in prevalence of cardiometabolic multimorbidity indicates the need for more research examining associated risk factors. Identifying multilevel risk factors is especially critical for U.S. health disparity populations who have been shown to e...

of 16