You are currently viewing a new version of our website. To view the old version click .

29 Results Found

  • Article
  • Open Access
524 Views
11 Pages

14 October 2025

Background/Objectives: In left-sided breast cancer radiotherapy, deep inspiration breath-hold (DIBH) reduces radiation dose to the heart; however, its success depends on the patient’s ability to maintain reproducible and stable breath-holds. Al...

  • Article
  • Open Access
1,392 Views
13 Pages

Robustness of Machine Learning Predictions for Determining Whether Deep Inspiration Breath-Hold Is Required in Breast Cancer Radiation Therapy

  • Wlla E. Al-Hammad,
  • Masahiro Kuroda,
  • Ghaida Al Jamal,
  • Mamiko Fujikura,
  • Ryo Kamizaki,
  • Kazuhiro Kuroda,
  • Suzuka Yoshida,
  • Yoshihide Nakamura,
  • Masataka Oita and
  • Yoshinori Tanabe
  • + 6 authors

Background/Objectives: Deep inspiration breath-hold (DIBH) is a commonly used technique to reduce the mean heart dose (MHD), which is critical for minimizing late cardiac side effects in breast cancer patients undergoing radiation therapy (RT). Altho...

  • Article
  • Open Access
1,044 Views
18 Pages

Application of the Deep Inspiration Breath-Hold Technique in Proton Therapy for Mediastinal Lymphomas: Initial Experience

  • Magdalena Garbacz,
  • Tomasz Skóra,
  • Anna Cepiga,
  • Gabriela Foltyńska,
  • Jan Gajewski,
  • Eleonora Góra,
  • Dominika Kędzierska-Pardel,
  • Wiktor Komenda,
  • Dawid Krzempek and
  • Emilia Krzywonos
  • + 7 authors

14 June 2025

Background: This work presents the procedures and application of the deep inspiration breath-hold (DIBH) technique for mediastinal lymphoma patients at a proton therapy (PT) center. It also discusses the implementation and validation of the surface-g...

  • Article
  • Open Access
5 Citations
3,736 Views
14 Pages

Artificial Intelligence-Based Patient Selection for Deep Inspiration Breath-Hold Breast Radiotherapy from Respiratory Signals

  • Alessandra Vendrame,
  • Cristina Cappelletto,
  • Paola Chiovati,
  • Lorenzo Vinante,
  • Masud Parvej,
  • Angela Caroli,
  • Giovanni Pirrone,
  • Loredana Barresi,
  • Annalisa Drigo and
  • Michele Avanzo

14 April 2023

Purpose: to predict eligibility for deep inspiration breath-hold (DIBH) radiotherapy (RT) treatment of patients with left breast cancer from analysis of respiratory signal, using Deep Bidirectional Long Short-Term Memory (BLSTM) recurrent neural netw...

  • Perspective
  • Open Access
31 Citations
3,809 Views
13 Pages

A Critical Overview of Predictors of Heart Sparing by Deep-Inspiration-Breath-Hold Irradiation in Left-Sided Breast Cancer Patients

  • Gianluca Ferini,
  • Vito Valenti,
  • Anna Viola,
  • Giuseppe Emmanuele Umana and
  • Emanuele Martorana

18 July 2022

Radiotherapy represents an essential part of the therapeutic algorithm for breast cancer patients after conservative surgery. The treatment of left-sided tumors has been associated with a non-negligible risk of developing late-onset cardiovascular di...

  • Article
  • Open Access
1,635 Views
14 Pages

A Prospective Study on Deep Inspiration Breath Hold Thoracic Radiation Therapy Guided by Bronchoscopically Implanted Electromagnetic Transponders

  • Yuzhong Jeff Meng,
  • Nikhil P. Mankuzhy,
  • Mohit Chawla,
  • Robert P. Lee,
  • Ellen D. Yorke,
  • Zhigang Zhang,
  • Emily Gelb,
  • Seng Boh Lim,
  • John J. Cuaron and
  • Abraham J. Wu
  • + 5 authors

17 April 2024

Background: Electromagnetic transponders bronchoscopically implanted near the tumor can be used to monitor deep inspiration breath hold (DIBH) for thoracic radiation therapy (RT). The feasibility and safety of this approach require further study. Met...

  • Article
  • Open Access
30 Citations
7,345 Views
17 Pages

22 February 2019

Background: Several studies have investigated cardiac dose reduction when utilizing the deep inspiration breath hold (DIBH) technique in patients undergoing radiotherapy for left-sided breast cancer. This paper aims to recommend potential selection c...

  • Article
  • Open Access
2 Citations
2,944 Views
17 Pages

6 February 2024

Hodgkin lymphomas are radiosensitive and curable tumors that often involve the mediastinum. However, the application of radiation therapy to the mediastinum is associated with late effects including cardiac and pulmonary toxicities and secondary canc...

  • Article
  • Open Access
5 Citations
2,645 Views
14 Pages

29 June 2023

Left-sided breast cancer radiotherapy can lead to late cardiovascular complications, including ischemic events. To mitigate these risks, cardiac-sparing techniques such as deep-inspiration breath-hold (DIBH) and intensity-modulated radiotherapy (IMRT...

  • Article
  • Open Access
2 Citations
4,088 Views
13 Pages

Mean Heart Dose Prediction Using Parameters of Single-Slice Computed Tomography and Body Mass Index: Machine Learning Approach for Radiotherapy of Left-Sided Breast Cancer of Asian Patients

  • Wlla E. Al-Hammad,
  • Masahiro Kuroda,
  • Ryo Kamizaki,
  • Nouha Tekiki,
  • Hinata Ishizaka,
  • Kazuhiro Kuroda,
  • Kohei Sugimoto,
  • Masataka Oita,
  • Yoshinori Tanabe and
  • Majd Barham
  • + 4 authors

4 August 2023

Deep inspiration breath-hold (DIBH) is an excellent technique to reduce the incidental radiation received by the heart during radiotherapy in patients with breast cancer. However, DIBH is costly and time-consuming for patients and radiotherapy staff....

  • Case Report
  • Open Access
667 Views
15 Pages

Online Adaptive Radiotherapy for Left-Sided Breast Cancer with Comprehensive Regional Nodal Coverage Including the Internal Mammary Chain: Case Report and Narrative Review

  • Damir Vučinić,
  • Matea Lekić,
  • Mihaela Mlinarić,
  • Giovanni Ursi,
  • Nikola Šegedin,
  • Vanda Leipold,
  • Domagoj Kosmina,
  • Hrvoje Kaučić,
  • Karla Schwarz and
  • Dragan Schwarz

20 November 2025

Online adaptive radiotherapy mitigates errors in absorbed dose delivery due to daily anatomical changes during hypofractionated breast treatment, particularly when comprehensive nodal therapy includes the internal mammary chain. To illustrate this, w...

  • Study Protocol
  • Open Access
2 Citations
2,282 Views
10 Pages

Efficacity of Deep Inspiration Breath Hold and Intensity-Modulated Radiotherapy in Preventing Perfusion Defect for Left Sided Breast Cancer (EDIPE): A Prospective Cohort Study Protocol

  • Jordan Eber,
  • Cyrille Blondet,
  • Martin Schmitt,
  • David G. Cox,
  • Claire Vit,
  • Clara Le Fèvre,
  • Delphine Antoni,
  • Fabrice Hubele and
  • Georges Noel

25 April 2023

Breast radiotherapy can lead to radiation-induced cardiac disease, particularly in left breast cancers. Recent studies have shown that subclinical cardiac lesions, such as myocardial perfusion deficits, may occur early after radiotherapy. The primary...

  • Article
  • Open Access
3,344 Views
14 Pages

A Pilot Study on the Influence of Diaphragmatic Function on Iliopsoas Muscle Activity in Individuals with Chronic Ankle Instability

  • Takumi Jiroumaru,
  • Shun Nomura,
  • Yutaro Hyodo,
  • Michio Wachi,
  • Junko Ochi,
  • Nobuko Shichiri and
  • Takamitsu Fujikawa

This study examined the impact of different breath-holding conditions on iliopsoas and other hip flexor muscle activity in individuals with chronic ankle instability (CAI). It has been hypothesised that impaired diaphragmatic function influences ilio...

  • Article
  • Open Access
18 Citations
4,887 Views
11 Pages

Fast Phase-Contrast Cine MRI for Assessing Intracranial Hemodynamics and Cerebrospinal Fluid Dynamics

  • Naoki Ohno,
  • Tosiaki Miyati,
  • Tomohiro Noda,
  • Noam Alperin,
  • Takashi Hamaguchi,
  • Masako Ohno,
  • Tatsuhiko Matsushita,
  • Mitsuhito Mase,
  • Toshifumi Gabata and
  • Satoshi Kobayashi

We propose fast phase-contrast cine magnetic resonance imaging (PC-cine MRI) to allow breath-hold acquisition, and we compared intracranial hemo- and hydrodynamic parameters obtained during breath holding between full inspiration and end expiration....

  • Article
  • Open Access
295 Views
10 Pages

Quality-of-Life Comparison of Three Different Breath-Hold Techniques for Left-Sided Breast Radiation

  • Caroline Hircock,
  • Adrian Wai Chan,
  • Anh Hoang,
  • Hanbo Chen,
  • Merrylee McGuffin,
  • Danny Vesprini,
  • Liying Zhang,
  • Matt Wronski and
  • Irene Karam

5 December 2025

Purpose: This study aimed to compare QoL outcomes among patients undergoing active breathing control (ABC), voluntary deep inspiration breath hold (vDIBH), and surface-guided radiation therapy (SGRT). Methods: This was a non-randomized, three-arm cli...

  • Article
  • Open Access
332 Views
17 Pages

Three-Dimensional Look-Locker Method for Free-Breathing T1 Mapping of Oxygen-Enhanced Pulmonary Magnetic Resonance Imaging

  • Pengfei Xu,
  • Jichang Zhang,
  • Jie Zeng,
  • Yulin Wang,
  • Xinyu Dou,
  • Yiling Fan,
  • Thomas Meersmann and
  • Chengbo Wang

Oxygen-enhanced magnetic resonance imaging (OE-MRI) enables non-invasive assessment of lung function by measuring longitudinal relaxation time (T1) changes induced by alternating inhalation of room air and pure oxygen. In this study, the pulmonary T1...

  • Article
  • Open Access
1 Citations
1,960 Views
10 Pages

Effects of Hook Maneuver on Oxygen Saturation Recovery After −40 m Apnea Dive—A Randomized Crossover Trial

  • Francisco DeAsís-Fernández,
  • Álvaro Reina-Varona,
  • Evangelos Papotsidakis,
  • Juan Lafuente and
  • José Fierro-Marrero

15 January 2025

To reduce the risk of syncope, trained breath-hold divers (BHDs) use a specialized breathing technique after surfacing called “hook breathing” (HB). It consists of a full inspiration followed by a Valsalva-like maneuver and with subsequen...

  • Article
  • Open Access
3 Citations
2,135 Views
18 Pages

Interplay Effect in Spot-Scanning Proton Therapy with Rescanning, Breath Holding, and Gating: A Phantom Study

  • Mikhail Belikhin,
  • Alexander Shemyakov,
  • Dmitry Ivanov and
  • Irina Zavestovskaya

20 September 2024

The interplay effect is a challenge when using proton scanning beams for the treatment of thoracic and abdominal cancers. The aim of this study was to evaluate the facility-specific interplay effect in terms of dose distortion and irradiation time fo...

  • Review
  • Open Access
485 Views
19 Pages

Radiation-Induced Valvular Heart Disease: A Narrative Review of Epidemiology, Diagnosis and Management

  • Andreea-Mădălina Varvara,
  • Cătălina Andreea Parasca,
  • Vlad Anton Iliescu and
  • Ruxandra Oana Jurcuț

Mediastinal radiotherapy plays a central role in the treatment of several malignancies, particularly Hodgkin lymphoma and breast cancer. However, exposure to thoracic radiation is associated with long-term cardiovascular complications, among which va...

  • Article
  • Open Access
8 Citations
3,558 Views
16 Pages

Monitoring Respiratory Motion during VMAT Treatment Delivery Using Ultra-Wideband Radar

  • Anwar Fallatah,
  • Miodrag Bolic,
  • Miller MacPherson and
  • Daniel J. La Russa

16 March 2022

The goal of this paper is to evaluate the potential of a low-cost, ultra-wideband radar system for detecting and monitoring respiratory motion during radiation therapy treatment delivery. Radar signals from breathing motion patterns simulated using a...

  • Article
  • Open Access
2 Citations
2,467 Views
12 Pages

Retrospective Analysis for Dose Reduction to Organs at Risk with New Personalized Breast Holder (PERSBRA) in Left Breast IMRT

  • Chiu-Ping Chen,
  • Tung-Ho Chen,
  • Jeng-Fong Chiou,
  • Yi-Ju Chen,
  • Chia-Chun Kuo,
  • Kuo-Hsiung Tseng,
  • Meng-Yun Chung,
  • Chun-You Chen,
  • Jeng-You Wu and
  • Long-Sheng Lu
  • + 1 author

25 August 2022

This study evaluated dose differences in normal organs at risk, such as the lungs, heart, left anterior descending artery (LAD), right coronary artery, left ventricle, and right breast under personalized breast holder (PERSBRA), when using intensity-...

  • Article
  • Open Access
20 Citations
12,674 Views
11 Pages

Breathing, (S)Training and the Pelvic Floor—A Basic Concept

  • Helena Talasz,
  • Christian Kremser,
  • Heribert Johannes Talasz,
  • Markus Kofler and
  • Ansgar Rudisch

Background: The current scientific literature is inconsistent regarding the potential beneficial or deleterious effects of high-intensity physical activities on the pelvic floor (PF) in women. So far, it has not been established with certainty whethe...

  • Article
  • Open Access
9 Citations
3,516 Views
12 Pages

9 October 2021

Background: For advanced breast cancer with lymph node involvement, adjuvant radiotherapy (RT) with regional nodal irradiation (RNI) has been indicated to reduce cancer recurrence and mortality. However, an extensive RT volume is associated with norm...

  • Article
  • Open Access
2,196 Views
10 Pages

31 May 2024

Women with left-sided breast cancer receiving adjuvant radiotherapy have increased incidence of cardiac mortality due to ischemic heart disease; to date, no threshold dose for late cardiac/pulmonary morbidity or mortality has been established. We inv...

  • Article
  • Open Access
1 Citations
1,836 Views
10 Pages

Preventing Cardiotoxicity in Personalized Breast Irradiation

  • Edy Ippolito,
  • Carlo Greco,
  • Maristella Marrocco,
  • Carla Germana Rinaldi,
  • Michele Fiore,
  • Luca Eolo Trodella,
  • Rolando Maria D’Angelillo and
  • Sara Ramella

26 October 2023

Background: This study aims to assess the benefit of a deep inspiration breath hold (DIBH) over the standard irradiation technique, and eventually to identify anatomical and/or treatment preplanning characteristics correlated with the LAD dose. Metho...

  • Article
  • Open Access
7 Citations
3,288 Views
12 Pages

Impact of Breast Size on Dosimetric Indices in Proton Versus X-ray Radiotherapy for Breast Cancer

  • Lisa Cunningham,
  • Scott Penfold,
  • Eileen Giles,
  • Hien Le and
  • Michala Short

8 April 2021

Deep inspiration breath hold (DIBH) radiotherapy is a technique used to manage early stage left-sided breast cancer. This study compared dosimetric indices of patient-specific X-ray versus proton therapy DIBH plans to explore differences in target co...

  • Article
  • Open Access
5 Citations
3,109 Views
13 Pages

1 April 2021

With the introduction of modern sophisticated radiotherapy (RT) techniques, the significance of accuracy has increased considerably. This study evaluated the necessity of pre-treatment and intra-fractional cone-beam computed tomography (CBCT) by anal...

  • Review
  • Open Access
193 Views
21 Pages

The Prone-Position Whole Breast Irradiation Paradox: Where Do We Stand? A Comprehensive Review

  • Chris Monten,
  • Ilaria Benevento,
  • Antonietta Montagna,
  • Edy Ippolito,
  • Paola Anselmo,
  • Luciana Rago,
  • Barbara D’Andrea,
  • Angela Solazzo,
  • Antonella Bianculli and
  • Raffaele Tucciariello
  • + 6 authors

5 January 2026

Over the past two decades, interest in prone-position whole breast irradiation (WBI) as an effective and practical alternative to supine treatment has been growing a lot. Although solid scientific data has provided evidence of substantial dosimetric...

  • Article
  • Open Access
2 Citations
3,124 Views
13 Pages

Evolving Trends and Patterns of Utilization of Magnetic Resonance-Guided Radiotherapy at a Single Institution, 2018–2024

  • Robert A. Herrera,
  • Eyub Y. Akdemir,
  • Rupesh Kotecha,
  • Kathryn E. Mittauer,
  • Matthew D. Hall,
  • Adeel Kaiser,
  • Nema Bassiri-Gharb,
  • Noah S. Kalman,
  • Yonatan Weiss and
  • Tino Romaguera
  • + 6 authors

10 January 2025

Background/Objectives: Over the past decade, significant advances have been made in image-guided radiotherapy (RT) particularly with the introduction of magnetic resonance (MR)-guided radiotherapy (MRgRT). However, the optimal clinical applications o...