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31 Results Found

  • Article
  • Open Access
13 Citations
3,407 Views
20 Pages

1 December 2019

The urban heat island (UHI) is one of the essential phenomena of the modern urban climate. In recent years, urbanization in China has gradually accelerated, and the heat island effect has also intensified as the urban impervious surface area and the...

  • Article
  • Open Access
14 Citations
5,649 Views
20 Pages

CoCUN, a Novel Ubiquitin Binding Domain Identified in N4BP1

  • Ridvan Nepravishta,
  • Federica Ferrentino,
  • Walter Mandaliti,
  • Anna Mattioni,
  • Janine Weber,
  • Simona Polo,
  • Luisa Castagnoli,
  • Gianni Cesareni,
  • Maurizio Paci and
  • Elena Santonico

Ubiquitin binding domains (UBDs) are modular elements that bind non-covalently to ubiquitin and act as downstream effectors and amplifiers of the ubiquitination signal. With few exceptions, UBDs recognize the hydrophobic path centered on Ile44, inclu...

  • Article
  • Open Access
10 Citations
3,069 Views
21 Pages

Identification of a Prognostic Signature for Ovarian Cancer Based on Ubiquitin-Related Genes Suggesting a Potential Role for FBXO9

  • Xiaomei Luo,
  • Yingjie Wang,
  • Hao Zhang,
  • Guangquan Chen,
  • Jindan Sheng,
  • Xiu Tian,
  • Renhao Xue and
  • Yu Wang

30 November 2023

Background: Ovarian cancer (OV) is associated with high mortality and poses challenges in diagnosis and prognosis prediction. Ubiquitin-related genes (UbRGs) are involved in the initiation and progression of cancers, but have still not been utilized...

  • Article
  • Open Access
2 Citations
4,521 Views
23 Pages

This paper will be focusing on discussions on how to use small-scale, higher-institution-based film festivals (including film competitions) as a vehicle to motivate students who are majoring in media and screen production to improve their production...

  • Article
  • Open Access
2 Citations
3,187 Views
10 Pages

Effect of Hydrophobicity on the Self-Assembly Behavior of Urea Benzene Derivatives in Aqueous Solution

  • Yuna Okamoto,
  • Kosuke Morishita,
  • Yasufumi Fuchi,
  • Shigeki Kobayashi and
  • Satoru Karasawa

3 July 2018

Urea benzene derivatives (UBD) with amphiphilic side chains showed self-assembly behavior in aqueous solution to form nanoparticles ~100 nm in size. Subsequent thermal treatment led to additional self-assembly of the nanoparticles due to dehydration...

  • Review
  • Open Access
26 Citations
8,478 Views
20 Pages

24 October 2011

This paper describes an experimental investigation of formation damage in a fractured carbonate core sample under underbalanced drilling (UBD) conditions. A major portion of this study has concentrated on problems which are often associated with UBD...

  • Article
  • Open Access
3,169 Views
10 Pages

TRPA1-related drugs alter sensation, particularly in conditions of inflammation. To further characterize the role of these drugs in bladder sensation, the TRPA1 agonist cinnamaldehyde (CMA) and oral true cinnamon spice were examined in preclinical mo...

  • Article
  • Open Access
7 Citations
3,779 Views
18 Pages

The Use of Mushrooms and Spirulina Algae as Supplements to Prevent Growth Inhibition in a Pre-Clinical Model for an Unbalanced Diet

  • Roni Sides,
  • Shelley Griess-Fishheimer,
  • Janna Zaretsky,
  • Astar Shitrit,
  • Rotem Kalev-Altman,
  • Reut Rozner,
  • Olga Beresh,
  • Maïtena Dumont,
  • Svetlana Penn and
  • Ron Shahar
  • + 1 author

29 November 2021

Today’s eating patterns are characterized by the consumption of unbalanced diets (UBDs) resulting in a variety of health consequences on the one hand, and the consumption of dietary supplements in order to achieve overall health and wellness on...

  • Article
  • Open Access
1,538 Views
12 Pages

Proximal Co-Translation Facilitates Detection of Weak Protein-Protein Interactions

  • Alina Kordonsky,
  • Matan Gabay,
  • Aurelia Rosinoff,
  • Reut Avishid,
  • Amir Flornetin,
  • Noam Deouell,
  • Taimaa Abd Alkhaleq,
  • Noa Efron,
  • Shoham Milshtein and
  • Julia M. Shifman
  • + 2 authors

16 October 2024

Ubiquitin (Ub) signals are recognized and decoded into cellular responses by Ub-receptors, proteins that tether the Ub-binding domain(s) (UBDs) with response elements. Typically, UBDs bind mono-Ub in highly dynamic and weak affinity manners, presenti...

  • Technical Note
  • Open Access
3 Citations
2,765 Views
14 Pages

15 December 2022

The Badain Jaran Desert (BJD) and surrounding deserts are the main sources of sand and dust storms in Asia. However, for complex factors, the descriptions of the sand dune dynamics in the BJD and investigations on the contribution of the BJD to the f...

  • Review
  • Open Access
7 Citations
11,200 Views
15 Pages

29 September 2010

This paper describes an analytical approach to investigate the nature of short overbalanced conditions and time effects during underbalanced drilling (UBD) in a naturally fractured reservoir. This study uses an analytical model which is developed for...

  • Review
  • Open Access
55 Citations
14,178 Views
16 Pages

Mechanisms of Generating Polyubiquitin Chains of Different Topology

  • Randy Suryadinata,
  • Siti Nur Ain Roesley,
  • George Yang and
  • Boris Šarčević

1 July 2014

Ubiquitination is an important post-translational process involving attachment of the ubiquitin molecule to lysine residue/s on a substrate protein or on another ubiquitin molecule, leading to the formation of protein mono-, multi- or polyubiquitinat...

  • Article
  • Open Access
428 Views
14 Pages

21 September 2025

In SF6 gas-insulated equipment, solid dielectrics critically degrade insulation performance by reducing the electric field’s ability to withstand gas gaps. To investigate the critical role played by solid dielectric surfaces during the initial...

  • Article
  • Open Access
25 Citations
5,401 Views
21 Pages

Elemental Analysis and In Vitro Evaluation of Antibacterial and Antifungal Activities of Usnea barbata (L.) Weber ex F.H. Wigg from Călimani Mountains, Romania

  • Violeta Popovici,
  • Laura Bucur,
  • Suzana Ioana Calcan,
  • Elena Iulia Cucolea,
  • Teodor Costache,
  • Dan Rambu,
  • Verginica Schröder,
  • Cerasela Elena Gîrd,
  • Daniela Gherghel and
  • Gabriela Vochita
  • + 2 authors

23 December 2021

This study aims to complete our research on Usnea barbata (L.) Weber ex F.H. Wigg (U. barbata) from the Călimani Mountains, Romania, with an elemental analysis and to explore its antibacterial and antifungal potential. Thus, we analyzed twenty-t...

  • Article
  • Open Access
1,337 Views
17 Pages

17 October 2024

Fallen leaves and their decomposition directly deposit leaf wax n-alkanes into sediments, which can be used to identify local flora. These n-alkanes are important for studying past vegetation and climate, but their distribution in sediments must be k...

  • Article
  • Open Access
2 Citations
3,724 Views
14 Pages

Assessing the Direct Binding of Ark-Like E3 RING Ligases to Ubiquitin and Its Implication on Their Protein Interaction Network

  • Dimitris G. Mintis,
  • Anastasia Chasapi,
  • Konstantinos Poulas,
  • George Lagoumintzis and
  • Christos T. Chasapis

19 October 2020

The ubiquitin pathway required for most proteins’ targeted degradation involves three classes of enzymes: E1-activating enzyme, E2-conjugating enzyme, and E3-ligases. The human Ark2C is the single known E3 ligase that adopts an alternative, Ub-...

  • Article
  • Open Access
1,324 Views
19 Pages

18 July 2025

A series of eleven new N-alkyl 3-(3-benzyloxyquinoxalin-2-yl) propanamides were prepared based on the azide coupling of 3-(3-benzyloxyquinoxalin-2-yl) propanhydrazide with a variety of primary and secondary amines and the consequent conjunction of a...

  • Article
  • Open Access
31 Citations
11,499 Views
12 Pages

University Students’ Antibiotic Use and Knowledge of Antimicrobial Resistance: What Are the Common Myths?

  • Nurul Shaheera Shahpawee,
  • Li Ling Chaw,
  • Siti Hanna Muharram,
  • Hui Poh Goh,
  • Zahid Hussain and
  • Long Chiau Ming

We aimed to assess antibiotic usage and knowledge regarding antibiotics and antimicrobial resistance (AMR) among undergraduate students of the Universiti Brunei Darussalam (UBD), public university located in Brunei Darussalam. A cross-sectional study...

  • Article
  • Open Access
6 Citations
3,364 Views
12 Pages

T Cell Receptor Genotype and Ubash3a Determine Susceptibility to Rat Autoimmune Diabetes

  • John P. Mordes,
  • Laura Cort,
  • Zhijun Liu,
  • Ryan Eberwine,
  • Elizabeth P. Blankenhorn and
  • Brian G. Pierce

1 June 2021

Genetic analyses of human type 1 diabetes (T1D) have yet to reveal a complete pathophysiologic mechanism. Inbred rats with a high-risk class II major histocompatibility complex (MHC) haplotype (RT1B/Du) can illuminate such mechanisms. Using T1D-susce...

  • Article
  • Open Access
128 Citations
25,187 Views
19 Pages

Urban Planning and Smart City Decision Management Empowered by Real-Time Data Processing Using Big Data Analytics

  • Bhagya Nathali Silva,
  • Murad Khan,
  • Changsu Jung,
  • Jihun Seo,
  • Diyan Muhammad,
  • Jihun Han,
  • Yongtak Yoon and
  • Kijun Han

7 September 2018

The Internet of Things (IoT), inspired by the tremendous growth of connected heterogeneous devices, has pioneered the notion of smart city. Various components, i.e., smart transportation, smart community, smart healthcare, smart grid, etc. which are...

  • Review
  • Open Access
50 Citations
7,475 Views
19 Pages

Ubiquitination is a prominent posttranslational modification, in which the ubiquitin moiety is covalently attached to a target protein to influence protein stability, interaction partner and biological function. All seven lysine residues of ubiquitin...

  • Article
  • Open Access
32 Citations
4,765 Views
19 Pages

2 March 2017

Low pressure, low permeability, and low saturation of Chinese coal-bed methane (CBM) reservoirs make underbalanced drilling (UBD) widely used for mining CBM in China. In this study, mechanical behavior and permeability of coal rock were investigated...

  • Article
  • Open Access
1 Citations
2,982 Views
17 Pages

High-Content RNAi Phenotypic Screening Unveils the Involvement of Human Ubiquitin-Related Enzymes in Late Cytokinesis

  • Mikaël Boullé,
  • Laurianne Davignon,
  • Keïs Nabhane Saïd Halidi,
  • Salomé Guez,
  • Emilie Giraud,
  • Marcel Hollenstein and
  • Fabrice Agou

30 November 2022

CEP55 is a central regulator of late cytokinesis and is overexpressed in numerous cancers. Its post-translationally controlled recruitment to the midbody is crucial to the structural coordination of the abscission sequence. Our recent evidence that C...

  • Article
  • Open Access
3 Citations
2,160 Views
14 Pages

6 September 2023

Cables are usually bent into a U-shape to cross obstacles during installation: this includes the upward-bending mode (UBM) and the downward-bending mode (DBM). An experimental study was conducted to investigate the combustion behavior of U-shaped cab...

  • Review
  • Open Access
11 Citations
5,657 Views
14 Pages

Regulation of Interferon Induction by the Ubiquitin-Like Modifier FAT10

  • Mei Min Mah,
  • Nicola Roverato and
  • Marcus Groettrup

23 June 2020

The revelation that the human major histocompatibility complex (MHC) class I locus encodes a ubiquitin-like protein designated HLA-F adjacent transcript 10 (FAT10) or ubiquitin D (UBD) has attracted increasing attention to the function of this protei...

  • Article
  • Open Access
12 Citations
5,744 Views
17 Pages

Type I Interferon Signaling Is Required for Dacryoadenitis in the Nonobese Diabetic Mouse Model of Sjögren Syndrome

  • Yury Chaly,
  • Jennifer Y. Barr,
  • David A. Sullivan,
  • Helen E. Thomas,
  • Thomas C. Brodnicki and
  • Scott M. Lieberman

20 October 2018

Nonobese diabetic (NOD) mice spontaneously develop lacrimal and salivary gland autoimmunity similar to human Sjögren syndrome. In both humans and NOD mice, the early immune response that drives T-cell infiltration into lacrimal and salivary glan...

  • Article
  • Open Access
3 Citations
3,053 Views
12 Pages

Red Kale (Brassica oleracea L. ssp. acephala L. var. sabellica) Induces Apoptosis in Human Colorectal Cancer Cells In Vitro

  • Kamila Rachwał,
  • Iwona Niedźwiedź,
  • Adam Waśko,
  • Tomasz Laskowski,
  • Paweł Szczeblewski,
  • Wirginia Kukula-Koch and
  • Magdalena Polak-Berecka

5 October 2023

This article presents the results of studies investigating the effect of red kale (Brassica oleracea L. ssp. acephala L. var. sabellica) extract on cancer cells (HT-29). The cytotoxicity of the red kale extract was assessed using MTT and LDH assays,...

  • Article
  • Open Access
4 Citations
2,830 Views
17 Pages

Endothelial Cell Response in Kawasaki Disease and Multisystem Inflammatory Syndrome in Children

  • Jihoon Kim,
  • Chisato Shimizu,
  • Ming He,
  • Hao Wang,
  • Hal M. Hoffman,
  • Adriana H. Tremoulet,
  • John Y.-J. Shyy and
  • Jane C. Burns

1 August 2023

Although Kawasaki disease (KD) and multisystem inflammatory syndrome in children (MIS-C) share some clinical manifestations, their cardiovascular outcomes are different, and this may be reflected at the level of the endothelial cell (EC). We performe...

  • Article
  • Open Access
26 Citations
6,611 Views
16 Pages

Antioxidant and Cytotoxic Activities of Usnea barbata (L.) F.H. Wigg. Dry Extracts in Different Solvents

  • Violeta Popovici,
  • Laura Bucur,
  • Antoanela Popescu,
  • Verginica Schröder,
  • Teodor Costache,
  • Dan Rambu,
  • Iulia Elena Cucolea,
  • Cerasela Elena Gîrd,
  • Aureliana Caraiane and
  • Daniela Gherghel
  • + 2 authors

1 May 2021

Lichens represent a significant source of antioxidants due to numerous metabolites that can reduce free radicals. Usnea barbata (L.) F.H. Wigg. has been recognized and used since ancient times for its therapeutic effects, some of which are based on i...

  • Article
  • Open Access
27 Citations
5,309 Views
31 Pages

12 March 2019

Due to the uncertainty of formation properties and improper wellbore stability analysis methods, the input parameters are often uncertain and the required mud weight to prevent wellbore collapse is too large, which might cause an incorrect result. Ho...

  • Article
  • Open Access
3 Citations
2,703 Views
11 Pages

Lifetime Comparisons of Organic Light-Emitting Diodes Fabricated by Solution and Evaporation Processes

  • Kuo-Chun Huang,
  • Jeng-Yue Chen,
  • Yen-Hua Lin,
  • Fuh-Shyang Juang and
  • Yu-Sheng Tsai

21 January 2023

In this paper, a blue fluorescent organic light-emitting diode (OLED) with a 1 cm2 emitting area was fabricated by a solution process. The ITO/spin MADN:13% UBD-07/TPBi/Al was used as the basic structure in which to add a hole-injection layer PEDOT:P...