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Mechanisms of Generating Polyubiquitin Chains of Different Topology

1
CSIRO Materials Science and Engineering, Parkville, Victoria 3052, Australia
2
Cell Cycle and Cancer Unit, St. Vincent's Institute of Medical Research, Fitzroy, Victoria 3065, Australia
3
Department of Medicine, St. Vincent's Hospital, University of Melbourne, Fitzroy, Victoria 3065, Australia
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Author to whom correspondence should be addressed.
Cells 2014, 3(3), 674-689; https://doi.org/10.3390/cells3030674
Received: 13 May 2014 / Revised: 11 June 2014 / Accepted: 19 June 2014 / Published: 1 July 2014
(This article belongs to the Special Issue Protein Ubiquitination)
Ubiquitination is an important post-translational process involving attachment of the ubiquitin molecule to lysine residue/s on a substrate protein or on another ubiquitin molecule, leading to the formation of protein mono-, multi- or polyubiquitination. Protein ubiquitination requires a cascade of three enzymes, where the interplay between different ubiquitin-conjugating and ubiquitin-ligase enzymes generates diverse ubiquitinated proteins topologies. Structurally diverse ubiquitin conjugates are recognized by specific proteins with ubiquitin-binding domains (UBDs) to target the substrate proteins of different pathways. The mechanism/s for generating the different ubiquitinated proteins topologies is not well understood. Here, we will discuss our current understanding of the mechanisms underpinning the generation of mono- or polyubiquitinated substrates. In addition, we will discuss how linkage-specific polyubiquitin chains through lysines-11, -48 or -63 are formed to target proteins to different fates by binding specific UBD proteins. View Full-Text
Keywords: protein ubiquitination; ubiquitin chain topologies; polyubiquitination protein ubiquitination; ubiquitin chain topologies; polyubiquitination
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MDPI and ACS Style

Suryadinata, R.; Roesley, S.N.A.; Yang, G.; Šarčević, B. Mechanisms of Generating Polyubiquitin Chains of Different Topology. Cells 2014, 3, 674-689. https://doi.org/10.3390/cells3030674

AMA Style

Suryadinata R, Roesley SNA, Yang G, Šarčević B. Mechanisms of Generating Polyubiquitin Chains of Different Topology. Cells. 2014; 3(3):674-689. https://doi.org/10.3390/cells3030674

Chicago/Turabian Style

Suryadinata, Randy, Siti N.A. Roesley, George Yang, and Boris Šarčević. 2014. "Mechanisms of Generating Polyubiquitin Chains of Different Topology" Cells 3, no. 3: 674-689. https://doi.org/10.3390/cells3030674

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