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457 Results Found

  • Article
  • Open Access
17 Citations
4,931 Views
12 Pages

Availability of Real-World Data in Italy: A Tool to Navigate Regional Healthcare Utilization Databases

  • Edlira Skrami,
  • Flavia Carle,
  • Simona Villani,
  • Paola Borrelli,
  • Antonella Zambon,
  • Giovanni Corrao,
  • Paolo Trerotoli,
  • Vincenzo Guardabasso and
  • Rosaria Gesuita

The purpose of the study was to map and describe the healthcare utilization databases (HUDs) available in Italy’s 19 regions and two autonomous provinces and develop a tool to navigate through them. A census of the HUDs covering the population...

  • Article
  • Open Access
3 Citations
2,427 Views
11 Pages

Development and Validation of a Novel Pre-Pregnancy Score Predictive of Preterm Birth in Nulliparous Women Using Data from Italian Healthcare Utilization Databases

  • Ivan Merlo,
  • Anna Cantarutti,
  • Alessandra Allotta,
  • Elisa Eleonora Tavormina,
  • Marica Iommi,
  • Marco Pompili,
  • Federico Rea,
  • Antonella Agodi,
  • Anna Locatelli and
  • Giovanni Corrao
  • + 4 authors

Background: Preterm birth is a major worldwide public health concern, being the leading cause of infant mortality. Understanding of risk factors remains limited, and early identification of women at high risk of preterm birth is an open challenge. Ob...

  • Article
  • Open Access
5 Citations
3,141 Views
10 Pages

Understanding Patterns of Adherence to Antifibrotic Treatment in Idiopathic Pulmonary Fibrosis: Insights from an Italian Prospective Cohort Study

  • Marica Iommi,
  • Francesca Gonnelli,
  • Martina Bonifazi,
  • Andrea Faragalli,
  • Federico Mei,
  • Marco Pompili,
  • Flavia Carle and
  • Rosaria Gesuita

Background: Pirfenidone and Nintedanib have significantly improved the prognosis of patients with idiopathic pulmonary fibrosis (IPF), reducing mortality risk and exacerbations. This study aimed to analyze antifibrotic treatment utilization and its a...

  • Article
  • Open Access
1,365 Views
14 Pages

Background: Dedifferentiated liposarcoma (DDLPS) is a rare, aggressive tumour with poor survival outcomes in advanced settings. This study assessed the incidence/prevalence, treatment patterns, survival, healthcare resource utilization (HCRU), and co...

  • Article
  • Open Access
6 Citations
2,928 Views
10 Pages

Prognosis and Survival in Idiopathic Pulmonary Fibrosis in the Era of Antifibrotic Therapy in Italy: Evidence from a Longitudinal Population Study Based on Healthcare Utilization Databases

  • Marica Iommi,
  • Andrea Faragalli,
  • Martina Bonifazi,
  • Federico Mei,
  • Lara Letizia Latini,
  • Marco Pompili,
  • Flavia Carle and
  • Rosaria Gesuita

The aim was to evaluate the determinants of acute exacerbation (AE) and death in new cases of idiopathic pulmonary fibrosis (IPF) using administrative databases in the Marche Region. Adults at their first prescription of antifibrotics or hospitalizat...

  • Article
  • Open Access
3 Citations
4,318 Views
16 Pages

Balancing Benefits and Harms of COVID-19 Vaccines: Lessons from the Ongoing Mass Vaccination Campaign in Lombardy, Italy

  • Giovanni Corrao,
  • Federico Rea,
  • Matteo Franchi,
  • Danilo Cereda,
  • Antonio Barone,
  • Catia Rosanna Borriello,
  • Giulia Petra Della Valle,
  • Michele Ercolanoni,
  • Jose Jara and
  • Guido Bertolaso
  • + 11 authors

15 April 2022

Background. Limited evidence exists on the balance between the benefits and harms of the COVID-19 vaccines. The aim of this study is to compare the benefits and safety of mRNA-based (Pfizer-BioNTech and Moderna) and adenovirus-vectored (Oxford-AstraZ...

  • Article
  • Open Access
1 Citations
2,397 Views
10 Pages

Association of Insomnia with 30-Day Postpartum Readmission: A Retrospective Analysis

  • Anthony M. Kendle,
  • Justin Swanson,
  • Jason L. Salemi and
  • Judette M. Louis

Insomnia is prevalent in pregnancy and is associated with increased use of health services. We aimed to evaluate the association between insomnia diagnosed at the delivery hospitalization and risk of 30-day postpartum readmission. We conducted a retr...

  • Article
  • Open Access
3 Citations
3,406 Views
10 Pages

Community-based case management for medical aid beneficiaries was implemented in Korea to promote the rational use of medical care and stabilize the financial system. This study investigated the economic impact of community-based case management on r...

  • Feature Paper
  • Article
  • Open Access
1 Citations
2,717 Views
9 Pages

Pediatric multiple sclerosis (MS) and neuromyelitis optica (NMO) are rare acquired demyelinating syndrome with limited epidemiological data available, particularly in non-Western setting. This study aimed to demonstrate the epidemiology of pediatric...

  • Review
  • Open Access
2 Citations
3,274 Views
17 Pages

Real-world data (RWD) has emerged as a crucial component in understanding and improving patient outcomes across various medical conditions, including retinal diseases. Health claims databases, generated from healthcare reimbursement claims, offer a c...

  • Article
  • Open Access
2 Citations
2,506 Views
11 Pages

21 January 2025

Background/Objectives: Hospital length of stay (LOS) is widely analyzed and serves as a benchmark for assessing changes during hospitalization. This study introduced a method to estimate patients’ LOS and highlighted the variations in LOS among...

  • Article
  • Open Access
47 Citations
7,565 Views
10 Pages

Burden of Endometriosis: Infertility, Comorbidities, and Healthcare Resource Utilization

  • Vered H. Eisenberg,
  • Dean H. Decter,
  • Gabriel Chodick,
  • Varda Shalev and
  • Clara Weil

21 February 2022

The goal of our study was to evaluate the burden of endometriosis in the community by comparing healthcare resource utilization, total direct medical costs, infertility, and comorbidity rates of women with and without a diagnosis of endometriosis. A...

  • Article
  • Open Access
2,007 Views
12 Pages

Hospitalization Trends and Healthcare Resource Utilization for Fecal Impactions in Pediatric Patients with Functional Constipation

  • Diem Le,
  • Hafiza Durrani,
  • Jasmine Khatana,
  • Sujithra Velayuthan,
  • Senthilkumar Sankararaman and
  • Aravind Thavamani

17 January 2025

Objectives: To analyze the clinical characteristics, trends in hospitalization, and healthcare resource utilization of pediatric patients with fecal impaction. Methods: We utilized the Healthcare Cost and Utilization Project (HCUP) databases, includi...

  • Article
  • Open Access
2,427 Views
13 Pages

23 April 2025

Background and Objectives: Low back pain (LBP) is a highly prevalent musculoskeletal condition that frequently recurs, leading to increased healthcare utilization and socioeconomic burden. While short-term management strategies are well-documented, l...

  • Article
  • Open Access
18 Citations
3,520 Views
15 Pages

Healthcare Utilization in Different Stages among Patients with Dementia: A Nationwide Population-Based Study

  • Yu-Han Chen,
  • Yi-Chen Lai,
  • Yu-Cih Wu,
  • Jun Sasaki,
  • Kang-Ting Tsai and
  • Chung-Han Ho

To evaluate the trend of healthcare utilization among patients with dementia (PwD) in different post-diagnosis periods, Taiwan’s nationwide population database was used in this study. PwD were identified on the basis of dementia diagnoses during 2002...

  • Article
  • Open Access
5 Citations
3,763 Views
14 Pages

In this study, we utilized ontology and machine learning methods to analyze the current results on vaccine adverse events. With the VAERS (Vaccine Adverse Event Reporting System) Database, the side effects of COVID-19 vaccines are summarized, and a r...

  • Article
  • Open Access
3 Citations
3,417 Views
17 Pages

Although data-based healthcare innovation has been spotlighted in South Korea in recent years, previous studies have made little effort to systematically predict various possible future outcomes in the data-driven healthcare economy. This study inves...

  • Article
  • Open Access
2,495 Views
14 Pages

Determinants of Government Expenditures with Health Insurance Beneficiaries in the Brazilian Health System

  • Leonardo Moreira,
  • João Vitor Marques Teodoro de Lima,
  • Murilo Mazzotti Silvestrini and
  • Flavia Mori Sarti

22 November 2024

Background/Objectives: The Brazilian health system provides healthcare financed by the public and private sector, being the first designed to encompass universal healthcare coverage delivered to the population without charge to patients (Sistema &Uac...

  • Article
  • Open Access
1 Citations
3,164 Views
13 Pages

Research on climate-related disasters and healthcare infrastructure has largely focused on short-term, localized impacts. This study examined the long-term association between climate-related disasters and healthcare facilities across 3108 contiguous...

  • Review
  • Open Access
22 Citations
4,350 Views
15 Pages

As the COVID-19 pandemic continues, healthcare services have been grossly overwhelmed by the pandemic. Due to this circumstance, routine care for individuals with type 2 diabetes mellitus (T2DM) has been temporarily disrupted. The purpose of this sys...

  • Article
  • Open Access
884 Views
26 Pages

Profiling Patients with Chronic Ulcers Using K-Means Clustering and Analysis of the Impact on the Consumption of Medical Resources: Retrospective Study on Hospitalized Patients in Romania

  • Mona Taroi (Yassin Cataniciu),
  • Ilie Gligorea,
  • Radu Fleacă,
  • Liliana Vecerzan (Novac),
  • Andrada Prihoi and
  • Carmen-Daniela Domnariu

4 September 2025

Background/Objectives: Chronic ulcers represent a major public health concern, being associated with substantial morbidity, impaired quality of life, and significant costs to healthcare systems. Against the backdrop of an aging population and increas...

  • Article
  • Open Access
3 Citations
3,518 Views
11 Pages

16 September 2022

Since 2001, China has been an aging society; it is expected to become superaged by 2033. This rapid aging trend poses a challenge to the elderly regarding their pension services and healthcare. Primary healthcare has great potential for serving older...

  • Review
  • Open Access
12 Citations
4,078 Views
14 Pages

Big Data in Studying Acute Pain and Regional Anesthesia

  • Lukas M. Müller-Wirtz and
  • Thomas Volk

1 April 2021

The digital transformation of healthcare is advancing, leading to an increasing availability of clinical data for research. Perioperative big data initiatives were established to monitor treatment quality and benchmark outcomes. However, big data ana...

  • Review
  • Open Access
8 Citations
3,853 Views
16 Pages

Rapid Scoping Review: Empathy in Health Sciences Curriculum

  • Renee Robinson,
  • Kelleen Meluski,
  • Tracy Hellem,
  • Travis Hedwig,
  • Natalie Hansen,
  • Jennifer Adams,
  • Mary Nies and
  • Krista Salazar

Empathy, the process of coming to know, understand, and care for another person, is a skill that can be learned; however, there is not a shared definition of empathy or understanding of how to operationalize empathy into practice. Healthcare worker e...

  • Article
  • Open Access
5 Citations
3,514 Views
7 Pages

A Population-Based Study of Healthcare Resource Utilization in Patients with Mitral Valve Prolapse

  • Sin-Cih Chen,
  • Sudha Xirasagar,
  • Ju-Chi Liu,
  • Yi-Wei Kao,
  • Ben-Chang Shia,
  • Tzong-Hann Yang and
  • Herng-Ching Lin

This study investigated differences in the utilization of healthcare services between subjects with mitral valve prolapse (MVP) and comparison subjects using data from Taiwan’s National Health Insurance population-based database, 138,493 patien...

  • Article
  • Open Access
3 Citations
2,698 Views
14 Pages

Identifying Clusters of Adherence to Cardiovascular Risk Reduction Behaviors and Persistence with Medication in New Lipid-Lowering Drug Users. Impact on Healthcare Utilization

  • Sara Malo,
  • María José Rabanaque,
  • Lina Maldonado,
  • Belén Moreno-Franco,
  • Armando Chaure-Pardos,
  • María Jesús Lallana,
  • María Pilar Rodrigo and
  • Isabel Aguilar-Palacio

25 February 2021

We sought to identify specific profiles of new lipid-lowering drug users based on adherence to a healthy lifestyle and persistence with medication, and to characterize co-morbidities, co-treatments, and healthcare utilization for each of the profiles...

  • Article
  • Open Access
4 Citations
2,852 Views
16 Pages

The difficulties in accessibility and affordability of healthcare services have posed persistent challenges to the Chinese government ever since the 1990s. This research aimed to explore the perceived accessibility and affordability of the healthcare...

  • Review
  • Open Access
8 Citations
6,035 Views
14 Pages

Mental Health in Healthcare Workers Post-COVID-19: A Latin American Review and Insights into Personalized Management Strategies

  • Sandra Muñoz-Ortega,
  • Daniela Santamaría-Guayaquil,
  • Jade Pluas-Borja,
  • Geovanny Alvarado-Villa,
  • Verónica Sandoval,
  • Rubén Alvarado,
  • Ivan Cherrez-Ojeda and
  • Marco Faytong-Haro

25 June 2024

Over the COVID-19 pandemic, the impact of enduring mental health on healthcare workers has become increasingly evident. This review focuses on post-pandemic mental health challenges faced by healthcare personnel in Latin America. This highlights the...

  • Article
  • Open Access
19 Citations
4,838 Views
20 Pages

Characteristics and Service Utilization by Complex Chronic and Advanced Chronic Patients in Catalonia: A Retrospective Seven-Year Cohort-Based Study of an Implemented Chronic Care Program

  • Sebastià J. Santaeugènia,
  • Joan C. Contel,
  • Emili Vela,
  • Montserrat Cleries,
  • Paloma Amil,
  • Eva M. Melendo-Azuela,
  • Esther Gil-Sánchez,
  • Victoria Mir and
  • Jordi Amblàs-Novellas

The Chronic Care Program introduced in Catalonia in 2011 focuses on improving the identification and management of complex chronic (CCPs) and advanced chronic patients (ACPs) by implementing an individualized care model. Its first stage is their iden...

  • Review
  • Open Access
1,697 Views
22 Pages

20 August 2025

Background: In healthcare education, understanding and managing cognitive load is crucial for enhancing learning outcomes for students, healthcare professionals, patients, and the general public. Despite numerous studies developing cognitive load cla...

  • Article
  • Open Access
33 Citations
4,918 Views
12 Pages

Background: A healthcare system refers to a typical network production system. Network data envelopment analysis (DEA) show an advantage than traditional DEA in measure the efficiency of healthcare systems. This paper utilized network data envelopmen...

  • Review
  • Open Access
13 Citations
4,172 Views
21 Pages

Facilitators and Barriers to Oral Healthcare for Women and Children with Low Socioeconomic Status in the United States: A Narrative Review

  • Cristian Lieneck,
  • Erin Connelly,
  • Daryah Ireland,
  • Alexandra Jefferson,
  • Jesikuh Jones and
  • Nicole Breidel

10 August 2023

This rapid review examined facilitators and barriers affecting oral healthcare access and utilization among women and children with a low socioeconomic status (SES) in the United States from 2019 to the present. A comprehensive search was conducted a...

  • Systematic Review
  • Open Access
18 Citations
4,816 Views
11 Pages

SARS-CoV-2 mRNA Vaccine Breakthrough Infections in Fully Vaccinated Healthcare Personnel: A Systematic Review

  • Caterina Ledda,
  • Claudio Costantino,
  • Giuseppe Motta,
  • Rosario Cunsolo,
  • Patrizia Stracquadanio,
  • Giuseppe Liberti,
  • Helena C. Maltezou and
  • Venerando Rapisarda

The number of people vaccinated against COVID-19 increases worldwide every day; however, it is important to study the risk of breakthrough infections in vaccinated individuals at high risk of exposure such as healthcare personnel (HCP). A systematic...

  • Article
  • Open Access
1,973 Views
10 Pages

Utilization of Syndromic Vaginitis Diagnostic Testing Reduces 6-Month Follow-Up Outpatient Service Healthcare Costs—A Real-World Data Analysis

  • Azia Evans,
  • Maren S. Fragala,
  • Pallavi Upadhyay,
  • Andrea French,
  • Steven E. Goldberg and
  • Jairus Reddy

5 November 2024

Background/Objectives: Vaginitis is a common infection among women of reproductive age. Although various diagnostic methodologies exist, diagnosis without the utilization of available diagnostic tests remains prevalent. This study aimed to assess dow...

  • Systematic Review
  • Open Access
3 Citations
1,950 Views
16 Pages

14 January 2025

Background and Objectives: People living with HIV/AIDS have been impacted notably by the COVID-19 pandemic in diverse dimensions. Although some impacts of COVID-19 on PLHIV have been well documented, there is still insufficient research that captures...

  • Review
  • Open Access
100 Citations
18,272 Views
19 Pages

Social-Ecological Barriers to Access to Healthcare for Adolescents: A Scoping Review

  • Whitney Garney,
  • Kelly Wilson,
  • Kobi V. Ajayi,
  • Sonya Panjwani,
  • Skylar M. Love,
  • Sara Flores,
  • Kristen Garcia and
  • Christi Esquivel

Access to healthcare for adolescents is often overlooked in the United States due to federal and state-sponsored insurance programs such as Medicaid and the Children’s Health Insurance Program. While these types of programs provide some relief, the i...

  • Protocol
  • Open Access
8 Citations
3,500 Views
16 Pages

Lifetime Costs of Surviving Cancer—A Queensland Study (COS-Q): Protocol of a Large Healthcare Data Linkage Study

  • Katharina M. D. Merollini,
  • Louisa G. Gordon,
  • Joanne F. Aitken and
  • Michael G. Kimlin

Australia-wide, there are currently more than one million cancer survivors. There are over 32 million world-wide. A trend of increasing cancer incidence, medical innovations and extended survival places growing pressure on healthcare systems to manag...

  • Article
  • Open Access
277 Citations
17,670 Views
33 Pages

Investigating the Psychological Impact of COVID-19 among Healthcare Workers: A Meta-Analysis

  • Kavita Batra,
  • Tejinder Pal Singh,
  • Manoj Sharma,
  • Ravi Batra and
  • Nena Schvaneveldt

Previous meta-analyses were conducted during the initial phases of the COVID-19 pandemic, which utilized a smaller pool of data. The current meta-analysis aims to provide additional (and updated) evidence related to the psychological impact among hea...

  • Review
  • Open Access
921 Citations
82,494 Views
30 Pages

Blockchain Technology in Healthcare: A Systematic Review

  • Cornelius C. Agbo,
  • Qusay H. Mahmoud and
  • J. Mikael Eklund

Since blockchain was introduced through Bitcoin, research has been ongoing to extend its applications to non-financial use cases. Healthcare is one industry in which blockchain is expected to have significant impacts. Research in this area is relativ...

  • Article
  • Open Access
18 Citations
7,226 Views
28 Pages

Transforming Healthcare Analytics with FHIR: A Framework for Standardizing and Analyzing Clinical Data

  • Muhammad Ayaz,
  • Muhammad Fermi Pasha,
  • Tahani Jaser Alahmadi,
  • Nik Nailah Binti Abdullah and
  • Hend Khalid Alkahtani

In this study, we discussed our contribution to building a data analytic framework that supports clinical statistics and analysis by leveraging a scalable standards-based data model named Fast Healthcare Interoperability Resource (FHIR). We developed...

  • Proceeding Paper
  • Open Access
1 Citations
2,390 Views
5 Pages

15 November 2023

This research presents a cross-platform application, developed with Flutter, for the efficient integration and management of real-time data from wearable sensors including Apple Watch, Android Wear, and Empatica E4. Compatible with iOS and Android, t...

  • Review
  • Open Access
20 Citations
7,360 Views
12 Pages

Sub-Saharan African (SSA) countries face a growing burden of cardiovascular disease (CVD), attributed to economic, nutritional, demographic, and epidemiological transitions. These factors increase the prevalence of CVD risk factors, and the CVD burde...

  • Review
  • Open Access
7 Citations
6,457 Views
21 Pages

Healthcare Application of Failure Mode and Effect Analysis (FMEA): Is There Room in the Infectious Disease Setting? A Scoping Review

  • Marco Vecchia,
  • Paolo Sacchi,
  • Lea Nadia Marvulli,
  • Luca Ragazzoni,
  • Alba Muzzi,
  • Lorenzo Polo,
  • Raffaele Bruno and
  • Flavio Salio

Background: Failure mode and effect analysis (FMEA) is a valuable risk analysis tool aimed at predicting the potential failures of a system and preventing them from occurring. Since its initial use, it has also recently been applied to the healthcare...

  • Systematic Review
  • Open Access
2,843 Views
37 Pages

Social Determinants of Health in Pediatric Asthma and Allergic Diseases: A Systematic Review

  • Despoina Koumpagioti,
  • Dafni Moriki,
  • Barbara Boutopoulou,
  • Pantelis Perdikaris and
  • Konstantinos Douros

Objectives: This study aimed to synthesize evidence of the influence of multilevel social determinants of health (SDOHs) on asthma and allergic disease outcomes and healthcare utilization in children and adolescents, with a specific focus on how thes...

  • Systematic Review
  • Open Access
5 Citations
7,177 Views
21 Pages

Analysis of Risk Determinants of Neonatal Mortality in the Last Decade: A Systematic Literature Review (2013–2023)

  • Msatfa Nabila,
  • Aziz Baidani,
  • Yassmine Mourajid,
  • Milouda Chebabe and
  • Hilali Abderraouf

12 August 2024

This study aimed to analyze the determinants of neonatal mortality over the last decade (2013–2023), identifying key factors that have influenced neonatal outcomes both before and during the COVID-19 pandemic. Utilizing a systematic literature...

  • Article
  • Open Access
3 Citations
2,759 Views
16 Pages

Cardiovascular Disease Preliminary Diagnosis Application Using SQL Queries: Filling Diagnostic Gaps in Resource-Constrained Environments

  • Rafał Doniec,
  • Eva Odima Berepiki,
  • Natalia Piaseczna,
  • Szymon Sieciński,
  • Artur Piet,
  • Muhammad Tausif Irshad,
  • Ewaryst Tkacz,
  • Marcin Grzegorzek and
  • Wojciech Glinkowski

5 February 2024

Cardiovascular diseases (CVDs) are chronic diseases associated with a high risk of mortality and morbidity. Early detection of CVD is crucial to initiating timely interventions, such as appropriate counseling and medication, which can effectively man...

  • Review
  • Open Access
9 Citations
4,595 Views
11 Pages

The Use of Robotic Technology in the Healthcare of People above the Age of 65—A Systematic Review

  • Ann-Chatrin Linqvist Leonardsen,
  • Camilla Hardeland,
  • Ann Karin Helgesen,
  • Carina Bååth,
  • Lilliana del Busso and
  • Vigdis Abrahamsen Grøndahl

Aim: The integration of robots can help provide solutions in regards to the need for an increase in resources in healthcare. The aim of this review was to identify how robots are utilized in the healthcare of people who are over the age of 65 and how...

  • Article
  • Open Access
3 Citations
3,384 Views
11 Pages

13 July 2022

There is empirical evidence of an association between periodontitis and coronary heart disease (CHD). However, it is uncertain whether periodontal treatment in CHD patients might lead to reduced healthcare costs. This study aims to assess the associa...

  • Systematic Review
  • Open Access
3 Citations
5,666 Views
28 Pages

High-income countries like Aotearoa New Zealand are grappling with inequitable access to healthcare services. Out-of-pocket payments can lead to the reduced use of appropriate healthcare services, poorer health outcomes, and catastrophic health expen...

  • Article
  • Open Access
3 Citations
2,440 Views
11 Pages

Patterns of Healthcare Utilization Leading to Diagnosis of Young-Onset Colorectal Cancer (yCRC): Population-Based Case-Control Study

  • Ameer Farooq,
  • Carl J. Brown,
  • Eric C. Sayre,
  • Manoj J. Raval,
  • Jonathan M. Loree,
  • Ria Garg and
  • Mary A. De Vera

31 August 2022

Background: The increasing risk of young-onset colorectal cancer (yCRC) in adults < 50 years has called for better understanding of patients’ pathways to diagnosis. This study evaluated patterns of healthcare utilization before diagnosis of...

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