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30 Results Found

  • Article
  • Open Access
1 Citations
4,132 Views
10 Pages

16 July 2020

The confrontation between good and evil is one of the essential aspects of the fantasy genre. In George R.R. Martin’s epic fantasy novel series A Song of Ice and Fire (ASOIAF, 1996–2011), he approaches this conception from a critical poin...

  • Article
  • Open Access
1,400 Views
11 Pages

28 August 2024

This article seeks to understand maturity and fruitfulness in terms of going beyond oneself toward others and, ultimately, the divine Other. It suggests that, from a perspective of Christian theological anthropology, the pursuit of maturity and fruit...

  • Article
  • Open Access
51 Citations
5,321 Views
41 Pages

COVLIAS 2.0-cXAI: Cloud-Based Explainable Deep Learning System for COVID-19 Lesion Localization in Computed Tomography Scans

  • Jasjit S. Suri,
  • Sushant Agarwal,
  • Gian Luca Chabert,
  • Alessandro Carriero,
  • Alessio Paschè,
  • Pietro S. C. Danna,
  • Luca Saba,
  • Armin Mehmedović,
  • Gavino Faa and
  • Mannudeep K. Kalra
  • + 31 authors

Background: The previous COVID-19 lung diagnosis system lacks both scientific validation and the role of explainable artificial intelligence (AI) for understanding lesion localization. This study presents a cloud-based explainable AI, the “COVLIAS 2....

  • Article
  • Open Access
22 Citations
5,183 Views
34 Pages

COVLIAS 1.0Lesion vs. MedSeg: An Artificial Intelligence Framework for Automated Lesion Segmentation in COVID-19 Lung Computed Tomography Scans

  • Jasjit S. Suri,
  • Sushant Agarwal,
  • Gian Luca Chabert,
  • Alessandro Carriero,
  • Alessio Paschè,
  • Pietro S. C. Danna,
  • Luca Saba,
  • Armin Mehmedović,
  • Gavino Faa and
  • Manudeep K. Kalra
  • + 31 authors

Background: COVID-19 is a disease with multiple variants, and is quickly spreading throughout the world. It is crucial to identify patients who are suspected of having COVID-19 early, because the vaccine is not readily available in certain parts of t...

  • Review
  • Open Access
16 Citations
8,465 Views
47 Pages

Deep Learning Paradigm for Cardiovascular Disease/Stroke Risk Stratification in Parkinson’s Disease Affected by COVID-19: A Narrative Review

  • Jasjit S. Suri,
  • Mahesh A. Maindarkar,
  • Sudip Paul,
  • Puneet Ahluwalia,
  • Mrinalini Bhagawati,
  • Luca Saba,
  • Gavino Faa,
  • Sanjay Saxena,
  • Inder M. Singh and
  • Mostafa M. Fouda
  • + 33 authors

Background and Motivation: Parkinson’s disease (PD) is one of the most serious, non-curable, and expensive to treat. Recently, machine learning (ML) has shown to be able to predict cardiovascular/stroke risk in PD patients. The presence of COVI...

  • Review
  • Open Access
25 Citations
6,390 Views
51 Pages

Vascular Implications of COVID-19: Role of Radiological Imaging, Artificial Intelligence, and Tissue Characterization: A Special Report

  • Narendra N. Khanna,
  • Mahesh Maindarkar,
  • Anudeep Puvvula,
  • Sudip Paul,
  • Mrinalini Bhagawati,
  • Puneet Ahluwalia,
  • Zoltan Ruzsa,
  • Aditya Sharma,
  • Smiksha Munjral and
  • Jasjit S. Suri
  • + 32 authors

The SARS-CoV-2 virus has caused a pandemic, infecting nearly 80 million people worldwide, with mortality exceeding six million. The average survival span is just 14 days from the time the symptoms become aggressive. The present study delineates the d...

  • Article
  • Open Access
49 Citations
5,915 Views
36 Pages

COVLIAS 1.0: Lung Segmentation in COVID-19 Computed Tomography Scans Using Hybrid Deep Learning Artificial Intelligence Models

  • Jasjit S. Suri,
  • Sushant Agarwal,
  • Rajesh Pathak,
  • Vedmanvitha Ketireddy,
  • Marta Columbu,
  • Luca Saba,
  • Suneet K. Gupta,
  • Gavino Faa,
  • Inder M. Singh and
  • Mannudeep Kalra
  • + 30 authors

Background: COVID-19 lung segmentation using Computed Tomography (CT) scans is important for the diagnosis of lung severity. The process of automated lung segmentation is challenging due to (a) CT radiation dosage and (b) ground-glass opacities cause...

  • Article
  • Open Access
26 Citations
4,477 Views
36 Pages

Inter-Variability Study of COVLIAS 1.0: Hybrid Deep Learning Models for COVID-19 Lung Segmentation in Computed Tomography

  • Jasjit S. Suri,
  • Sushant Agarwal,
  • Pranav Elavarthi,
  • Rajesh Pathak,
  • Vedmanvitha Ketireddy,
  • Marta Columbu,
  • Luca Saba,
  • Suneet K. Gupta,
  • Gavino Faa and
  • Mannudeep K. Kalra
  • + 31 authors

1 November 2021

Background: For COVID-19 lung severity, segmentation of lungs on computed tomography (CT) is the first crucial step. Current deep learning (DL)-based Artificial Intelligence (AI) models have a bias in the training stage of segmentation because only o...

  • Article
  • Open Access
25 Citations
4,899 Views
27 Pages

COVLIAS 1.0 vs. MedSeg: Artificial Intelligence-Based Comparative Study for Automated COVID-19 Computed Tomography Lung Segmentation in Italian and Croatian Cohorts

  • Jasjit S. Suri,
  • Sushant Agarwal,
  • Alessandro Carriero,
  • Alessio Paschè,
  • Pietro S. C. Danna,
  • Marta Columbu,
  • Luca Saba,
  • Klaudija Viskovic,
  • Armin Mehmedović and
  • Mannudeep K. Kalra
  • + 34 authors

15 December 2021

(1) Background: COVID-19 computed tomography (CT) lung segmentation is critical for COVID lung severity diagnosis. Earlier proposed approaches during 2020–2021 were semiautomated or automated but not accurate, user-friendly, and industry-standa...

  • Review
  • Open Access
27 Citations
8,922 Views
39 Pages

Cardiovascular Risk Stratification in Diabetic Retinopathy via Atherosclerotic Pathway in COVID-19/Non-COVID-19 Frameworks Using Artificial Intelligence Paradigm: A Narrative Review

  • Smiksha Munjral,
  • Mahesh Maindarkar,
  • Puneet Ahluwalia,
  • Anudeep Puvvula,
  • Ankush Jamthikar,
  • Tanay Jujaray,
  • Neha Suri,
  • Sudip Paul,
  • Rajesh Pathak and
  • Jasjit S. Suri
  • + 38 authors

Diabetes is one of the main causes of the rising cases of blindness in adults. This microvascular complication of diabetes is termed diabetic retinopathy (DR) and is associated with an expanding risk of cardiovascular events in diabetes patients. DR,...

  • Review
  • Open Access
34 Citations
7,387 Views
33 Pages

Cardiovascular/Stroke Risk Stratification in Diabetic Foot Infection Patients Using Deep Learning-Based Artificial Intelligence: An Investigative Study

  • Narendra N. Khanna,
  • Mahesh A. Maindarkar,
  • Vijay Viswanathan,
  • Anudeep Puvvula,
  • Sudip Paul,
  • Mrinalini Bhagawati,
  • Puneet Ahluwalia,
  • Zoltan Ruzsa,
  • Aditya Sharma and
  • Jasjit S. Suri
  • + 31 authors

19 November 2022

A diabetic foot infection (DFI) is among the most serious, incurable, and costly to treat conditions. The presence of a DFI renders machine learning (ML) systems extremely nonlinear, posing difficulties in CVD/stroke risk stratification. In addition,...

  • Correction
  • Open Access
1 Citations
1,699 Views
17 Pages

Correction: Fraik et al. The Impacts of Dam Construction and Removal on the Genetics of Recovering Steelhead (Oncorhynchus mykiss) Populations across the Elwha River Watershed. Genes 2021, 12, 89

  • Alexandra K. Fraik,
  • John R. McMillan,
  • Martin Liermann,
  • Todd Bennett,
  • Michael L. McHenry,
  • Garrett J. McKinney,
  • Abigail H. Wells,
  • Gary Winans,
  • Joanna L. Kelley and
  • Krista M. Nichols
  • + 1 author

13 September 2022

In the original publication [...]

  • Article
  • Open Access
39 Citations
8,625 Views
30 Pages

The Impacts of Dam Construction and Removal on the Genetics of Recovering Steelhead (Oncorhynchus mykiss) Populations across the Elwha River Watershed

  • Alexandra K. Fraik,
  • John R. McMillan,
  • Martin Liermann,
  • Todd Bennett,
  • Michael L. McHenry,
  • Garrett J. McKinney,
  • Abigail H. Wells,
  • Gary Winans,
  • Joanna L. Kelley and
  • Krista M. Nichols
  • + 1 author

13 January 2021

Dam construction and longitudinal river habitat fragmentation disrupt important life histories and movement of aquatic species. This is especially true for Oncorhynchus mykiss that exhibits both migratory (steelhead) and non-migratory (resident rainb...

  • Article
  • Open Access
211 Citations
27,591 Views
38 Pages

Economics of Artificial Intelligence in Healthcare: Diagnosis vs. Treatment

  • Narendra N. Khanna,
  • Mahesh A. Maindarkar,
  • Vijay Viswanathan,
  • Jose Fernandes E Fernandes,
  • Sudip Paul,
  • Mrinalini Bhagawati,
  • Puneet Ahluwalia,
  • Zoltan Ruzsa,
  • Aditya Sharma and
  • Jasjit S. Suri
  • + 25 authors

9 December 2022

Motivation: The price of medical treatment continues to rise due to (i) an increasing population; (ii) an aging human growth; (iii) disease prevalence; (iv) a rise in the frequency of patients that utilize health care services; and (v) increase in th...

  • Article
  • Open Access
26 Citations
7,875 Views
16 Pages

Deep Learning Automation of Kidney, Liver, and Spleen Segmentation for Organ Volume Measurements in Autosomal Dominant Polycystic Kidney Disease

  • Arman Sharbatdaran,
  • Dominick Romano,
  • Kurt Teichman,
  • Hreedi Dev,
  • Syed I. Raza,
  • Akshay Goel,
  • Mina C. Moghadam,
  • Jon D. Blumenfeld,
  • James M. Chevalier and
  • Martin R. Prince
  • + 3 authors

13 July 2022

Organ volume measurements are a key metric for managing ADPKD (the most common inherited renal disease). However, measuring organ volumes is tedious and involves manually contouring organ outlines on multiple cross-sectional MRI or CT images. The aut...

  • Review
  • Open Access
16 Citations
7,944 Views
32 Pages

Cardiovascular/Stroke Risk Assessment in Patients with Erectile Dysfunction—A Role of Carotid Wall Arterial Imaging and Plaque Tissue Characterization Using Artificial Intelligence Paradigm: A Narrative Review

  • Narendra N. Khanna,
  • Mahesh Maindarkar,
  • Ajit Saxena,
  • Puneet Ahluwalia,
  • Sudip Paul,
  • Saurabh K. Srivastava,
  • Elisa Cuadrado-Godia,
  • Aditya Sharma,
  • Tomaz Omerzu and
  • Jasjit S. Suri
  • + 16 authors

Purpose: The role of erectile dysfunction (ED) has recently shown an association with the risk of stroke and coronary heart disease (CHD) via the atherosclerotic pathway. Cardiovascular disease (CVD)/stroke risk has been widely understood with the he...

  • Review
  • Open Access
7 Citations
5,173 Views
17 Pages

Reducing the Burden of Migraine: Safety and Efficacy of CGRP Pathway-Targeted Preventive Treatments

  • George R. Nissan,
  • Richard Kim,
  • Joshua M. Cohen,
  • Michael J. Seminerio,
  • Lynda J. Krasenbaum,
  • Karen Carr and
  • Vincent Martin

27 July 2022

Migraine is a highly disabling and often chronic neurological disease that affects more than one billion people globally. Preventive migraine treatment is recommended for individuals who have frequent and/or disabling attacks; however, many of the me...

  • Article
  • Open Access
7 Citations
4,731 Views
18 Pages

Potential psychological issues faced by British nuclear test veterans have been under-researched. This study assessed the prevalence of clinically relevant anxiety in British nuclear test veterans and aimed to explore experiences of worry and the bro...

  • Review
  • Open Access
78 Citations
19,075 Views
28 Pages

Extensive Sheep and Goat Production: The Role of Novel Technologies towards Sustainability and Animal Welfare

  • Severiano R. Silva,
  • Laura Sacarrão-Birrento,
  • Mariana Almeida,
  • David M. Ribeiro,
  • Cristina Guedes,
  • José Ramiro González Montaña,
  • Alfredo F. Pereira,
  • Konstantinos Zaralis,
  • Ana Geraldo and
  • André M. de Almeida
  • + 9 authors

31 March 2022

Sheep and goat extensive production systems are very important in the context of global food security and the use of rangelands that have no alternative agricultural use. In such systems, there are enormous challenges to address. These include, for i...

  • Article
  • Open Access
6 Citations
3,183 Views
34 Pages

An Energy Graph-Based Approach to Fault Diagnosis of a Transcritical CO2 Heat Pump

  • Kenneth R. Uren,
  • George van Schoor,
  • Martin van Eldik and
  • Johannes J. A. de Bruin

7 April 2020

The objective of this paper is to describe an energy-based approach to visualize, identify, and monitor faults that may occur in a water-to-water transcritical CO 2 heat pump system. A representation using energy attributes allows the abstrac...

  • Communication
  • Open Access
37 Citations
9,168 Views
19 Pages

Diagnosis of Breakthrough Fungal Infections in the Clinical Mycology Laboratory: An ECMM Consensus Statement

  • Jeffrey D. Jenks,
  • Jean-Pierre Gangneux,
  • Ilan S. Schwartz,
  • Ana Alastruey-Izquierdo,
  • Katrien Lagrou,
  • George R. Thompson III,
  • Cornelia Lass-Flörl,
  • Martin Hoenigl and
  • European Confederation of Medical Mycology (ECMM) Council Investigators

11 October 2020

Breakthrough invasive fungal infections (bIFI) cause significant morbidity and mortality. Their diagnosis can be challenging due to reduced sensitivity to conventional culture techniques, serologic tests, and PCR-based assays in patients undergoing a...

  • Article
  • Open Access
14 Citations
5,143 Views
29 Pages

Stroma Transcriptomic and Proteomic Profile of Prostate Cancer Metastasis Xenograft Models Reveals Prognostic Value of Stroma Signatures

  • Sofia Karkampouna,
  • Maria R. De Filippo,
  • Charlotte K. Y. Ng,
  • Irena Klima,
  • Eugenio Zoni,
  • Martin Spahn,
  • Frank Stein,
  • Per Haberkant,
  • George N. Thalmann and
  • Marianna Kruithof-de Julio

15 December 2020

Resistance acquisition to androgen deprivation treatment and metastasis progression are a major clinical issue associated with prostate cancer (PCa). The role of stroma during disease progression is insufficiently defined. Using transcriptomic and pr...

  • Review
  • Open Access
18 Citations
16,850 Views
19 Pages

The Critical Importance of Molecular Biomarkers and Imaging in the Study of Electrohypersensitivity. A Scientific Consensus International Report

  • Dominique Belpomme,
  • George L. Carlo,
  • Philippe Irigaray,
  • David O. Carpenter,
  • Lennart Hardell,
  • Michael Kundi,
  • Igor Belyaev,
  • Magda Havas,
  • Franz Adlkofer and
  • André Vander Vorst
  • + 22 authors

Clinical research aiming at objectively identifying and characterizing diseases via clinical observations and biological and radiological findings is a critical initial research step when establishing objective diagnostic criteria and treatments. Fai...

  • Article
  • Open Access
14 Citations
4,719 Views
14 Pages

Hantavirus in Panama: Twenty Years of Epidemiological Surveillance Experience

  • Blas Armién,
  • Carlos Muñoz,
  • Hector Cedeño,
  • Jacqueline R. Salazar,
  • Tybbyssay P. Salinas,
  • Publio González,
  • José Trujillo,
  • Deyanira Sánchez,
  • Jamileth Mariñas and
  • Itza de Mosca
  • + 28 authors

19 June 2023

Twenty years have passed since the emergence of hantavirus zoonosis in Panama at the beginning of this millennium. We provide an overview of epidemiological surveillance of hantavirus disease (hantavirus pulmonary syndrome and hantavirus fever) durin...

  • Article
  • Open Access
24 Citations
6,443 Views
15 Pages

A Novel CD206 Targeting Peptide Inhibits Bleomycin-Induced Pulmonary Fibrosis in Mice

  • Anghesom Ghebremedhin,
  • Ahmad Bin Salam,
  • Benjamin Adu-Addai,
  • Steve Noonan,
  • Richard Stratton,
  • Md Shakir Uddin Ahmed,
  • Chandra Khantwal,
  • George R. Martin,
  • Huixian Lin and
  • Clayton Yates
  • + 5 authors

26 April 2023

Activated M2-polarized macrophages are drivers of pulmonary fibrosis in several clinical scenarios, including Idiopathic Pulmonary Fibrosis (IPF). In this study, we investigated the effects of targeting the CD206 receptor in M2-like macrophages with...

  • Article
  • Open Access
3 Citations
2,409 Views
10 Pages

Modeling Cues May Reduce Sway Following Sit-To-Stand Transfer for People with Parkinson’s Disease

  • Rebecca A. Martin,
  • George Fulk,
  • Lee Dibble,
  • Ali Boolani,
  • Edgar R. Vieira and
  • Jennifer Canbek

12 May 2023

Cues are commonly used to overcome the effects of motor symptoms associated with Parkinson’s disease. Little is known about the impact of cues on postural sway during transfers. The objective of this study was to identify if three different typ...

  • Article
  • Open Access
7 Citations
4,669 Views
15 Pages

Clinical Quality Control of MRI Total Kidney Volume Measurements in Autosomal Dominant Polycystic Kidney Disease

  • Chenglin Zhu,
  • Hreedi Dev,
  • Arman Sharbatdaran,
  • Xinzi He,
  • Daniil Shimonov,
  • James M. Chevalier,
  • Jon D. Blumenfeld,
  • Yi Wang,
  • Kurt Teichman and
  • Martin R. Prince
  • + 2 authors

12 July 2023

Total kidney volume measured on MRI is an important biomarker for assessing the progression of autosomal dominant polycystic kidney disease and response to treatment. However, we have noticed that there can be substantial differences in the kidney vo...

  • Review
  • Open Access
732 Citations
103,940 Views
11 Pages

Review of Infant Feeding: Key Features of Breast Milk and Infant Formula

  • Camilia R. Martin,
  • Pei-Ra Ling and
  • George L. Blackburn

11 May 2016

Mothers’ own milk is the best source of nutrition for nearly all infants. Beyond somatic growth, breast milk as a biologic fluid has a variety of other benefits, including modulation of postnatal intestinal function, immune ontogeny, and brain develo...

  • Feature Paper
  • Article
  • Open Access
2 Citations
2,940 Views
16 Pages

Differential Infiltration of Key Immune T-Cell Populations Across Malignancies Varying by Immunogenic Potential and the Likelihood of Response to Immunotherapy

  • Islam Eljilany,
  • Sam Coleman,
  • Aik Choon Tan,
  • Martin D. McCarter,
  • John Carpten,
  • Howard Colman,
  • Abdul Rafeh Naqash,
  • Igor Puzanov,
  • Susanne M. Arnold and
  • Ahmad A. Tarhini
  • + 12 authors

3 December 2024

Background: Solid tumors vary by the immunogenic potential of the tumor microenvironment (TME) and the likelihood of response to immunotherapy. The emerging literature has identified key immune cell populations that significantly impact immune activa...

  • Article
  • Open Access
468 Views
15 Pages

Fabrication and Evaluation of Large Alumina Crucibles by Vat Photopolymerization Additive Manufacturing for High-Temperature Actinide Chemistry

  • R. Joey Griffiths,
  • Christy Santoyo,
  • Jean-Baptiste Forien,
  • Bradley Childs,
  • Andrew J. Swift,
  • Andrew Cho,
  • Alexander Wilson-Heid,
  • George Ankrah,
  • Devin Rappleye and
  • Kiel Holliday
  • + 2 authors

2 December 2025

Additive manufacturing (AM) offers opportunities to advance the design and function of ceramic tooling in high temperature actinide pyrochemistry. In technical ceramics such as alumina, conventional forming techniques often restrict design flexibilit...