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  • Article
  • Open Access
2 Citations
1,481 Views
12 Pages

Predictive Value of R2CHA2DS2-VA Score for 90-Day Functional Outcomes After Endovascular Thrombectomy in Acute Ischemic Stroke

  • Faruk Boyacı,
  • Cetin Kursad Akpınar,
  • Mustafa Kursat Sahin,
  • Murat Akcay,
  • Hasan Dogan,
  • Mustafa Yenercag,
  • Guney Erdogan,
  • Berkant Ozturk,
  • Yankı Boyacı and
  • Orhan Ince

Background and Objectives: Endovascular treatment (EVT) has been shown to enhance long-term recovery and lower mortality rates in patients with intracranial large vessel occlusion-associated acute ischemic strokes (AISs).We aimed to evaluate the pred...

(This article belongs to the Section Cardiology)
  • Article
  • Open Access
11 Citations
4,109 Views
10 Pages

RETRACTED: Validation of the CHA2DS2-VA Score (Excluding Female Sex) in Nonvalvular Atrial Fibrillation Patients: A Nationwide Population-Based Study

  • Sun Young Choi,
  • Moo Hyun Kim,
  • Hyo Bin Kim,
  • Sa Yul Kang,
  • Kwang Min Lee,
  • Kyung-Yae Hyun and
  • Sung-Cheol Yun

25 March 2022

Sex (i.e., female sex) confers one point for the CHA2DS2-VASc score. For this reason, females with atrial fibrillation (AF) always have a CHA2DS2-VASc score of at least 1. To compare the CHA2DS2-VA (excluding female sex) and CHA2DS2-VASc scores in Ko...

(This article belongs to the Special Issue Myths and Realities of Current Cardiovascular Diseases and Therapy)
  • Article
  • Open Access
201 Views
13 Pages

CHA2DS2-VA Score Predicts Mortality but Not Embolic Events in Left-Sided Infective Endocarditis

  • Andrea Oña,
  • Javier López,
  • María de Miguel-Álava,
  • Isidre Vilacosta,
  • Carmen Olmos,
  • Carmen Sáez,
  • Adrián Lozano,
  • Gonzalo Cabezón,
  • Pablo Zulet and
  • J. Alberto San Román
  • + 5 authors

The CHA2DS2-VASc score is widely used to predict thromboembolic events in non-valvular atrial fibrillation (AF) and has also been linked to adverse outcomes in diverse clinical contexts. The latest published European Guidelines on AF recommend the si...

(This article belongs to the Special Issue The Infective Endocarditis (2nd Edition))
  • Article
  • Open Access
1 Citations
1,414 Views
13 Pages

29 June 2025

Background/Objectives: Nonvalvular atrial fibrillation (NVAF) is a prevalent arrhythmia associated with elevated risks of stroke, systemic embolism, and mortality. Emerging evidence underscores the pivotal role of inflammation in NVAF pathogenesis. T...

(This article belongs to the Special Issue Novel Developments on Diagnosis and Treatment of Atrial Fibrillation)
  • Article
  • Open Access
4 Citations
1,529 Views
17 Pages

Thromboembolic Episodes in Patients with Systemic Lupus Erythematosus Without Atrial Fibrillation/Atrial Flutter Are Related to the Presence of at Least 3 Points in the CHA2DS2-VA Score: A Comprehensive Retrospective Analysis of 787 Patients

  • Radosław Dziedzic,
  • Michał Węgiel,
  • Andżelika Siwiec-Koźlik,
  • Magdalena Spałkowska,
  • Lech Zaręba,
  • Stanisława Bazan-Socha,
  • Mariusz Korkosz and
  • Joanna Kosałka-Węgiel

3 June 2025

Background/Objectives: Systemic lupus erythematosus (SLE) is an autoimmune disease associated with an increased prevalence of cardiac and cerebrovascular events. Despite advancements in management, no validated tools exist that can predict the risk o...

(This article belongs to the Special Issue Systemic Lupus Erythematosus: Current Trends and Therapeutic Innovations)
  • Article
  • Open Access
3 Citations
2,052 Views
18 Pages

Atrial Fibrillation Risk Scores as Potential Predictors of Significant Coronary Artery Disease in Chronic Coronary Syndrome: A Novel Diagnostic Approach

  • Alexandru-Florinel Oancea,
  • Paula Cristina Morariu,
  • Maria Godun,
  • Stefan Dorin Dobreanu,
  • Miron Mihnea,
  • Diana Gabriela Iosep,
  • Ana Maria Buburuz,
  • Ovidiu Mitu,
  • Alexandru Burlacu and
  • Mariana Floria
  • + 6 authors

18 July 2025

Chronic coronary syndrome (CCS) and atrial fibrillation (AF) are prevalent cardiovascular conditions that share numerous risk factors and pathophysiological mechanisms. While clinical scores commonly used in AF—such as CHA2DS2VA (which includes...

(This article belongs to the Special Issue Interdisciplinarity in Cardiovascular Diseases: From Pathophysiology to Diagnosis and Treatment: 3rd Edition)
  • Article
  • Open Access
242 Views
15 Pages

Long-Term Mortality Following Transvenous Lead Extraction: Data from EXTRACT Registry

  • Sylwia Gładysz-Wańha,
  • Michał Joniec,
  • Wojciech Wańha,
  • Eugeniusz Piłat,
  • Anna Drzewiecka,
  • Rafał Gardas,
  • Jolanta Biernat,
  • Andrzej Węglarzy,
  • Danuta Łoboda and
  • Krzysztof Stanisław Gołba
  • + 1 author

28 August 2026

Background/Objective: The EXTRACT registry cohort of 504 patients undergoing transvenous lead extraction (TLE) has been previously reported in terms of periprocedural safety and short-term outcomes. Data on long-term mortality and its predictors in t...

(This article belongs to the Section Cardiology)
  • Article
  • Open Access
1,101 Views
13 Pages

Evaluation of R2CHADS2, R2CHA2DS2-VASc, and R2CHA2DS2-VA Scores for the Prediction of In-Hospital Mortality in Patients with ST-Elevation Myocardial Infarction

  • Evliya Akdeniz,
  • Cennet Yıldız,
  • Mehmet Pisirici,
  • Hasan Ali Sinoplu,
  • Dilay Karabulut and
  • Fatma Nihan Turhan Çağlar

30 June 2025

Background/Objectives: Despite the contemporary management of ST segment elevation myocardial infarction (STEMI) patients, in-hospital mortality rates remain considerable. Therefore, the assessment of in-hospital mortality risk of patients with STEMI...

(This article belongs to the Section Cardiology)
  • Article
  • Open Access
6 Citations
2,474 Views
10 Pages

Sex-Related Differences in Left Atrial Low-Voltage Areas According to CHA2DS2-VA Scores among Patients with Atrial Fibrillation

  • Do Young Kim,
  • Yun Gi Kim,
  • Ha Young Choi,
  • Yun Young Choi,
  • Ki Yung Boo,
  • Kwang-No Lee,
  • Seung-Young Roh,
  • Jaemin Shim,
  • Jong-Il Choi and
  • Young-Hoon Kim

31 May 2022

(1) Background: We hypothesized that female sex would have a differential impact on left atrial (LA) low-voltage areas (LVAs) according to CHA2DS2-VA scores. (2) Methods: This study included 553 patients who underwent radiofrequency catheter ablation...

(This article belongs to the Special Issue New Insights into Atrial Fibrillation)
  • Viewpoint
  • Open Access
2 Citations
1,048 Views
21 Pages

Additional Stroke Risk Factors Beyond the CHA2DS2-VA Score in Non-Valvular Atrial Fibrillation: An Interdisciplinary Expert Opinion

  • Ersin Çagrı Simsek,
  • Sena Sert Sekerci,
  • Murat Gucun,
  • Seher Tanrikulu,
  • Emine Dundar Ahi,
  • Begum Ozdengulsun and
  • Dursun Aras

26 February 2026

Background/Objectives: Comorbidity and risk factor management and avoiding stroke are pillars of optimal atrial fibrillation management. In this article, the latest literature on additional stroke risk factors not included in the CHA2DS2-VA score is...

(This article belongs to the Section Cardiovascular Medicine)
  • Article
  • Open Access
4 Citations
1,728 Views
16 Pages

Validation of EuroSCORE II, ACEF Score, CHA2DS2-VASc, and CHA2DS2-VA in Patients Undergoing Left Main Coronary Artery Angioplasty: Analysis from All-Comers BIA-LM Registry

  • Emil Julian Dąbrowski,
  • Paweł Kralisz,
  • Konrad Nowak,
  • Kamil Gugała,
  • Przemysław Prokopczuk,
  • Grzegorz Mężyński,
  • Michał Święczkowski,
  • Sławomir Dobrzycki and
  • Marcin Kożuch

16 November 2024

Background: Simple surgical and clinical risk scores are useful in mortality prediction. Aims: The study’s aim was to validate three scores in real-world registry of percutaneous coronary intervention (PCI) for the left main coronary artery (LM...

(This article belongs to the Special Issue Cardiovascular and Cerebrovascular Emergencies: Advances in Clinical Research)
  • Article
  • Open Access
399 Views
17 Pages

Factors Associated with Documented Arrhythmia Recurrence After Cryoballoon Ablation in a Low-Risk Atrial Fibrillation Population Without Major Comorbidities

  • Murat Erdem Alp,
  • Veli Polat,
  • Süleyman Barutçu,
  • Güngör İlayda Bostancı Alp,
  • Yaser İslamoğlu,
  • Gazi Çapar,
  • Eyüp Özkan and
  • Taylan Akgün

20 August 2026

Background: Arrhythmia recurrence after cryoballoon ablation remains a clinically relevant problem in atrial fibrillation (AF). However, factors associated with documented recurrence in low-risk patients without major comorbidities are not well defin...

(This article belongs to the Section Cardiology)
  • Retraction
  • Open Access
3 Citations
1,563 Views
1 Page

26 October 2023

The journal retracts the article “Validation of the CHA2DS2-VA Score (Excluding Female Sex) in Nonvalvular Atrial Fibrillation Patients: A Nationwide Population-Based Study” [...]

(This article belongs to the Section Cardiovascular Medicine)
  • Article
  • Open Access
3 Citations
3,037 Views
12 Pages

16 June 2022

Purpose: Atrial fibrillation (AF) can be a valuable indicator of non-obstructive coronary artery disease (CAD) among older patients indicated for elective coronary angiography (CAG). Appropriate stratification of AF patients is crucial for avoiding u...

(This article belongs to the Topic Atrial Fibrillation: State-of-the-Art Techniques and Future Perspectives for Diagnosis, Rhythm Control, and Stroke Prophylaxis)
  • Article
  • Open Access
8 Citations
3,742 Views
10 Pages

Atrial Fibrillation on Patients with Vascular Dementia: A Fundamental Target for Correct Management

  • Giovanna Viticchi,
  • Lorenzo Falsetti,
  • Marco Burattini,
  • Vincenzo Zaccone,
  • Laura Buratti,
  • Marco Bartolini,
  • Gianluca Moroncini and
  • Mauro Silvestrini

Background: Atrial fibrillation (AF) is a risk factor for cerebrovascular diseases and vascular dementia (VAD). The aim of this study was to evaluate the effect of the adherence to anticoagulant therapy guidelines in patients with dementia and AF on...

(This article belongs to the Section Neurodegenerative Diseases)
  • Article
  • Open Access
4 Citations
2,717 Views
16 Pages

The CHA2DS2-VASC Score Predicts Mortality in Patients Undergoing Coronary Angiography

  • Nicholay Teodorovich,
  • Gera Gandelman,
  • Michael Jonas,
  • Yakov Fabrikant,
  • Michael Sraia Swissa,
  • Sara Shimoni,
  • Jacob George and
  • Moshe Swissa

9 October 2023

Background: The CHA2DS2-VASC score is used to predict the risk of thromboembolic complications in patients with atrial fibrillation (AF). We hypothesized that the CHA2DS2-VASC score can be used to predict mortality in patients undergoing coronary ang...

(This article belongs to the Special Issue Coronary Artery Disease from Pathogenetic Mechanisms to Postoperative Prognosis Research)
  • Article
  • Open Access
6 Citations
4,128 Views
14 Pages

Stroke Risk Stratification in Incident Atrial Fibrillation: A Sex-Specific Evaluation of CHA2DS2-VA and CHA2DS2-VASc

  • Jose L. Clua-Espuny,
  • Anna Panisello-Tafalla,
  • Jorgina Lucas-Noll,
  • Eulàlia Muria-Subirats,
  • Teresa Forcadell-Arenas,
  • Juan M. Carrera-Ortiz,
  • Pedro Molto-Balado,
  • Josep Clua-Queralt,
  • Immaculada Fusté-Anguera and
  • Silvia Reverte-Vilarroya

(1) Background: In the absence of locally validated tools, the CHA2DS2-VA score has been suggested as a substitute for the CHA2DS2-VASc score. This study compared the potential discrepancies between these scores. (2) Methods: The observational, retro...

  • Article
  • Open Access
1 Citations
1,391 Views
14 Pages

30 December 2025

Background/aims: Hypertension (HT) is a modifiable risk factor for the development of cardiovascular disease (CVD) in patients with atrial fibrillation (AF). There are no data on the use of the SCORE2 and SCORE2-OP risk scores used in patients with A...

(This article belongs to the Section Cardiology)
  • Article
  • Open Access
549 Views
11 Pages

What Drives Anticoagulant Selection in Patients Aged ≥85 Years with Atrial Fibrillation? Insights from the CRAFT Registry

  • Janusz Bednarski,
  • Monika Szewczak,
  • Marta Grzesiak,
  • Emilia Kamińska,
  • Maciej Karczewski,
  • Karolina Własiuk and
  • Michał Wojewódzki

15 May 2026

Background: Anticoagulation management in very elderly patients with atrial fibrillation (AF) is particularly challenging due to the coexistence of high thromboembolic and bleeding risks, often compounded by multiple comorbidities. Randomized clinica...

(This article belongs to the Section Cardiology)
  • Review
  • Open Access
1,034 Views
27 Pages

New Insights in the Diagnosis and Treatment of Atrial Fibrillation in Patients with Hypertrophic Obstructive Cardiomyopathy

  • Cristina-Mihaela Angelescu,
  • Toma Andrei Iosifescu,
  • Cristina Ioana Căldăraru,
  • Andrei Daniel Dermengiu,
  • Oana Raluca Ioniţă,
  • Horaţiu Moldovan and
  • Lucian Florin Dorobanţu

15 April 2026

Hypertrophic cardiomyopathy (HCM) is the most common genetic disease in the general population, with a variable phenotypic expression and symptomatology. Atrial fibrillation (AF) is the most common arrhythmia identified among patients diagnosed with...

(This article belongs to the Special Issue Cardiac Amyloidosis and Heart Failure: Clinical Pathophysiology, Diagnosis, and Therapeutic Strategies)
  • Article
  • Open Access
5 Citations
1,362 Views
18 Pages

Triglyceride-to-HDL Cholesterol Ratio Is Associated with Ischemic Stroke Risk in Patients—With Paroxysmal Atrial Fibrillation

  • Ciprian Ilie Rosca,
  • Daniel Florin Lighezan,
  • Doina Georgescu,
  • Horia Silviu Branea,
  • Nilima Rajpal Kundnani,
  • Ariana Violeta Nicoras,
  • Romina Georgiana Bita and
  • Daniel Dumitru Nisulescu

3 February 2026

Background: Ischemic stroke remains the most feared complication of atrial fibrillation (AF), and thromboembolic risk is commonly estimated using clinical scores that may not fully capture the cardiometabolic dimension of cerebrovascular vulnerabilit...

(This article belongs to the Special Issue Current Research in Metabolic Syndrome and Cardiometabolic Disorders)
  • Review
  • Open Access
8 Citations
4,554 Views
30 Pages

Non-Anticoagulation Strategies Aimed at Primary Stroke Prevention in Nascent Atrial Fibrillation

  • Luca Sgarra,
  • Vanessa Desantis,
  • Andrea Matteucci,
  • Vincenzo Paolo Caccavo,
  • Federica Troisi,
  • Antonio Di Monaco,
  • Francesco Mangini,
  • Grigorios Katsouras,
  • Andrea Igoren Guaricci and
  • Massimo Grimaldi
  • + 5 authors

At its earliest appearance, atrial fibrillation (AF) is often unnoticed, asymptomatic, and/or merely device-detected. Widespread use of heart-rate monitoring technologies has facilitated such “nascent atrial fibrillation (nAF)” recognitio...

(This article belongs to the Special Issue Cardiovascular Diseases in the Era of Precision Medicine)
  • Systematic Review
  • Open Access
1 Citations
1,727 Views
29 Pages

Visceral Embolic Events in Atrial Fibrillation: A Systematic Review and Meta-Analysis of Incidence, Mortality, and Risk Prediction

  • Yazan Jumah Alalwani,
  • Waleed Abdullah Alharthi,
  • Hadeel Khalid Bin-Shuiel,
  • Raghad Adel Badoghaish,
  • Saja Fawzi Alzanbaqi,
  • Lamees Naji Alsaleh,
  • Fatimah Essam Alzaid,
  • Mustafa Abdulwahab AlShayeb,
  • Fatimah Reda Algawez and
  • Eiman Mohammed AlShammari
  • + 3 authors

26 December 2025

Background: Visceral embolic events (VEE), including mesenteric, splenic, and renal infarctions, represent understudied complications of atrial fibrillation (AF) often subsumed within broader systemic embolic event categories. The 2024 European Socie...

(This article belongs to the Section Cardiology)
  • Article
  • Open Access
1 Citations
1,367 Views
16 Pages

Background and objective: Evidence of percutaneous left atrial appendage closure (LAAC) and oral anticoagulants (OACs) in non-valvular atrial fibrillation (NVAF) patients with intermediate-to-borderline high stroke risk is scarce. We aimed to compare...

(This article belongs to the Topic New Research on Atrial Fibrillation)
  • Article
  • Open Access
1 Citations
1,391 Views
27 Pages

Sarcopenia as a Prognostic Marker of Early Mortality After Surgery for Acute Aortic Dissection: A Prospective Cohort Study

  • Tomasz Semań,
  • Sabina Krupa-Nurcek,
  • Mateusz Szczupak,
  • Jacek Kobak,
  • Amelia Dąbrowska,
  • Wioletta Mędrzycka-Dąbrowska and
  • Kazimierz Widenka

1 April 2026

Introduction: Perioperative factors can significantly accelerate the development of sarcopenia in patients with aortic dissection, weakening their metabolic and functional reserves. Progressive sarcopenia after surgery is associated with a worse prog...

  • Article
  • Open Access
1 Citations
1,119 Views
15 Pages

Sex Differences in Individuals at High Risk of Atrial Fibrillation: A Primary Care Community Cohort Study, 2015–2024

  • Jose Luis Clúa-Espuny,
  • Anna Panisello-Tafalla,
  • Alba Hernández-Pinilla,
  • Josep Clua-Queralt,
  • Eulàlia Múria-Subirats,
  • Jorgina Lucas-Noll,
  • Pedro Moltó-Balado,
  • Teresa Forcadell-Arenas and
  • Silvia Reverté-Villarroya

18 November 2025

Background: Sex differences in epidemiology and outcomes in atrial fibrillation (AF) are well documented, but their role in early detection and risk stratification in primary care remains unclear. Methods: This study used an observational, retrospect...

(This article belongs to the Special Issue High-Risk Atrial Fibrillation in Patients with Cardiovascular Disease: Diagnosis, Comprehensive Risk Assessment, Comorbidities, and Anticoagulation Strategies)
  • Case Report
  • Open Access
1 Citations
762 Views
6 Pages

Autosomal Recessive Atrial Dilated Cardiomyopathy Due to NPPA Mutation in a Young Patient

  • Massimiliano Marini,
  • Manuela Iseppi,
  • Silvia Quintarelli,
  • Francesca Tedoldi,
  • Flavia Ravelli,
  • Roberto Bonmassari and
  • Eloisa Arbustini

Background: Atrial dilated cardiomyopathy (ADCM) related to homozygous Natriuretic Peptide Precursor A (NPPA) pathogenic variants is an exceptionally rare inherited atrial cardiomyopathy characterized by progressive atrial enlargement, supraventricul...

(This article belongs to the Special Issue Modern Approach to Complex Arrhythmias, 2nd Edition)
  • Article
  • Open Access
1 Citations
865 Views
12 Pages

Interatrial Block as a Common Finding in Patients with Acute Pulmonary Artery Embolism

  • Fabienne Kreimer,
  • Tobias J. Brix,
  • Felix K. Wegner,
  • Dennis Korthals,
  • Hilke Könemann,
  • Florian Doldi,
  • Julian Wolfes,
  • Antonius Büscher,
  • Christian Ellermann and
  • Michael Gotzmann
  • + 6 authors

27 November 2025

Background/Objectives: Electrocardiographic (ECG) findings such as sinus tachycardia and right bundle branch block are commonly associated with acute pulmonary embolism (PE). This study aimed to investigate the prevalence of advanced interatrial bloc...

(This article belongs to the Section Cardiovascular Medicine)